FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025828552> ?p ?o ?g. }

• W2025828552 endingPage "e56325" @default.
• W2025828552 startingPage "e56325" @default.
• W2025828552 abstract "Cytology-based screening for invasive cervical cancer (ICC) lacks sensitivity and specificity to discriminate between cervical intraepithelial neoplasia (CIN) likely to persist or progress from cases likely to resolve. Genome-wide approaches have been used to identify DNA methylation marks associated with CIN persistence or progression. However, associations between DNA methylation marks and CIN or ICC remain weak and inconsistent. Between 2008-2009, we conducted a hospital-based, case-control study among 213 Tanzania women with CIN 1/2/3 or ICC. We collected questionnaire data, biopsies, peripheral blood, cervical scrapes, Human papillomavirus (HPV) and HIV-1 infection status. We assessed PEG3 methylation status by bisulfite pyrosequencing. Multinomial logistic regression was used to estimate odds ratios (OR) and confidence intervals (CI 95%) for associations between PEG3 methylation status and CIN or ICC. After adjusting for age, gravidity, hormonal contraceptive use and HPV infection, a 5% increase in PEG3 DNA methylation was associated with increased risk for ICC (OR = 1.6; 95% CI 1.2-2.1). HPV infection was associated with a higher risk of CIN1-3 (OR = 15.7; 95% CI 5.7-48.6) and ICC (OR = 29.5, 95% CI 6.3-38.4). Infection with high risk HPV was correlated with mean PEG3 differentially methylated regions (DMRs) methylation (r = 0.34 p<0.0001), while the correlation with low risk HPV infection was weaker (r = 0.16 p = 0.047). Although small sample size limits inference, these data support that PEG3 methylation status has potential as a molecular target for inclusion in CIN screening to improve prediction of progression. Impact statement: We present the first evidence that aberrant methylation of the PEG3 DMR is an important co-factor in the development of Invasive cervical carcinoma (ICC), especially among women infected with high risk HPV. Our results show that a five percent increase in DNA methylation of PEG3 is associated with a 1.6-fold increase ICC risk. Suggesting PEG3 methylation status may be useful as a molecular marker for CIN screening to improve prediction of cases likely to progress." @default.
• W2025828552 created "2016-06-24" @default.
• W2025828552 creator A5008163736 @default.
• W2025828552 creator A5016313986 @default.
• W2025828552 creator A5018904268 @default.
• W2025828552 creator A5028148105 @default.
• W2025828552 creator A5039701124 @default.
• W2025828552 creator A5040762457 @default.
• W2025828552 creator A5041501999 @default.
• W2025828552 creator A5050150641 @default.
• W2025828552 creator A5055956090 @default.
• W2025828552 creator A5056466210 @default.
• W2025828552 creator A5061157006 @default.
• W2025828552 creator A5065434861 @default.
• W2025828552 creator A5065634340 @default.
• W2025828552 creator A5071695678 @default.
• W2025828552 creator A5071731897 @default.
• W2025828552 creator A5079878752 @default.
• W2025828552 date "2013-02-13" @default.
• W2025828552 modified "2023-10-15" @default.
• W2025828552 title "Associations between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer" @default.
• W2025828552 cites W1945270539 @default.
• W2025828552 cites W1963744267 @default.
• W2025828552 cites W1981989535 @default.
• W2025828552 cites W1985523983 @default.
• W2025828552 cites W1987350137 @default.
• W2025828552 cites W2006126177 @default.
• W2025828552 cites W2017770467 @default.
• W2025828552 cites W2025948533 @default.
• W2025828552 cites W2029654466 @default.
• W2025828552 cites W2038008310 @default.
• W2025828552 cites W2040289777 @default.
• W2025828552 cites W2055202552 @default.
• W2025828552 cites W2096199626 @default.
• W2025828552 cites W2112529753 @default.
• W2025828552 cites W2139439596 @default.
• W2025828552 cites W2159741041 @default.
• W2025828552 cites W2166632132 @default.
• W2025828552 cites W2168364037 @default.
• W2025828552 cites W2168745469 @default.
• W2025828552 cites W2168850910 @default.
• W2025828552 doi "https://doi.org/10.1371/journal.pone.0056325" @default.
• W2025828552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3571954" @default.
• W2025828552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23418553" @default.
• W2025828552 hasPublicationYear "2013" @default.
• W2025828552 type Work @default.
• W2025828552 sameAs 2025828552 @default.
• W2025828552 citedByCount "72" @default.
• W2025828552 countsByYear W20258285522013 @default.
• W2025828552 countsByYear W20258285522014 @default.
• W2025828552 countsByYear W20258285522015 @default.
• W2025828552 countsByYear W20258285522016 @default.
• W2025828552 countsByYear W20258285522017 @default.
• W2025828552 countsByYear W20258285522018 @default.
• W2025828552 countsByYear W20258285522019 @default.
• W2025828552 countsByYear W20258285522020 @default.
• W2025828552 countsByYear W20258285522021 @default.
• W2025828552 countsByYear W20258285522022 @default.
• W2025828552 countsByYear W20258285522023 @default.
• W2025828552 crossrefType "journal-article" @default.
• W2025828552 hasAuthorship W2025828552A5008163736 @default.
• W2025828552 hasAuthorship W2025828552A5016313986 @default.
• W2025828552 hasAuthorship W2025828552A5018904268 @default.
• W2025828552 hasAuthorship W2025828552A5028148105 @default.
• W2025828552 hasAuthorship W2025828552A5039701124 @default.
• W2025828552 hasAuthorship W2025828552A5040762457 @default.
• W2025828552 hasAuthorship W2025828552A5041501999 @default.
• W2025828552 hasAuthorship W2025828552A5050150641 @default.
• W2025828552 hasAuthorship W2025828552A5055956090 @default.
• W2025828552 hasAuthorship W2025828552A5056466210 @default.
• W2025828552 hasAuthorship W2025828552A5061157006 @default.
• W2025828552 hasAuthorship W2025828552A5065434861 @default.
• W2025828552 hasAuthorship W2025828552A5065634340 @default.
• W2025828552 hasAuthorship W2025828552A5071695678 @default.
• W2025828552 hasAuthorship W2025828552A5071731897 @default.
• W2025828552 hasAuthorship W2025828552A5079878752 @default.
• W2025828552 hasBestOaLocation W20258285521 @default.
• W2025828552 hasConcept C104317684 @default.
• W2025828552 hasConcept C121608353 @default.
• W2025828552 hasConcept C126322002 @default.
• W2025828552 hasConcept C131872663 @default.
• W2025828552 hasConcept C143998085 @default.
• W2025828552 hasConcept C150194340 @default.
• W2025828552 hasConcept C156957248 @default.
• W2025828552 hasConcept C190727270 @default.
• W2025828552 hasConcept C2777343196 @default.
• W2025828552 hasConcept C2778220009 @default.
• W2025828552 hasConcept C2778580637 @default.
• W2025828552 hasConcept C29456083 @default.
• W2025828552 hasConcept C33288867 @default.
• W2025828552 hasConcept C44249647 @default.
• W2025828552 hasConcept C54355233 @default.
• W2025828552 hasConcept C71924100 @default.
• W2025828552 hasConcept C86803240 @default.
• W2025828552 hasConceptScore W2025828552C104317684 @default.
• W2025828552 hasConceptScore W2025828552C121608353 @default.
• W2025828552 hasConceptScore W2025828552C126322002 @default.
• W2025828552 hasConceptScore W2025828552C131872663 @default.

• next