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• W2025836701 abstract "1 In this study we investigated the effects of dopamine receptor agonists and antagonists on rat striatal synaptosomal aromatic l-amino acid decarboxylase (AADC) activity. 2 The results show that 10−5–10−7 m cis-flupenthixol increased the striatal synaptosomal AADC activity (by 25% to 57%) in a time-dependent manner. SCH 23390 and remoxipride alone had little or no effect on striatal synaptosomal AADC activity, but in combination they increased AADC activity by 20%, suggesting that the increases in striatal synaptosomal AADC activity occurred only after blockade of both dopamine D1 and D2 receptors. 3 Treatment with (+)-amphetamine and (±)-2-(N-phenylethyl-N-propyl)amino-5-hydroxytetralin hydrochloride ((±)-PPHT) produced a reduction of striatal synaptosomal AADC activity in a concentration- and time-dependent manner. SKF 38393 and (−)-quinpirole, however, exhibited no effect on striatal synaptosomal AADC activity, suggesting that only the mixed dopamine receptor agonists can reduce the AADC activity. Incubation with apomorphine at a concentration of 10−4 m inhibited the AADC activity by 74% and this inhibition cannot be antagonized by SCH 23390, remoxipride or cis-flupenthixol, suggesting that apomorphine-induced inhibition of striatal synaptosomal AADC activity was not mediated by dopamine receptors. 4 cis-Flupenthixol can reverse the reduction of AADC activity induced by (+)-amphetamine and (±)-PPHT. The inhibition of AADC activity elicited by (±)-PPHT also can be reversed by SCH 23390 and remoxipride. 5 The inhibition of striatal synaptosomal AADC activity induced by (±)-PPHT is calcium-dependent and protein kinase C may play a role in the regulation of striatal AADC activity. 6 These studies show that striatal synaptosomal AADC activity is regulated by dopamine receptors and indicate that in vitro dopamine D1 and D2 receptors have a synergistic effect in this regulation." @default.
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• W2025836701 date "1994-05-01" @default.
• W2025836701 modified "2023-10-14" @default.
• W2025836701 title "Regulation of aromatic l-amino acid decarboxylase in rat striatal synaptosomes: effects of dopamine receptor agonists and antagonists" @default.
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• W2025836701 doi "https://doi.org/10.1111/j.1476-5381.1994.tb13023.x" @default.
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