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• W2025839215 abstract "A number of studies have provided estimates of the correlation between B-cell lymphoma 2 (Bcl-2) expression and its clinical significance in acute leukemia (AL); however, the results have been heterogeneous. In order to clarify the prognostic significance of Bcl-2 status in patients with AL, a systematic review and meta-analysis of 5 published studies including a total of 665 subjects was performed. The reported frequency of Bcl-2 expression was 0-99.00%. Bcl-2-positive patients had a higher median white blood cell count compared to Bcl-2-negative patients. Additionally, Bcl-2-negative patients had >2-fold higher odds of achieving complete remission (CR) compared to Bcl-2-positive patients. The summary hazard ratio of Bcl-2 negativity/positivity for CR was 0.62 [95% confidence interval: 0.53-0.81, P<0.001]. Although this meta-analysis was based on data abstracted from observational studies, our results may justify the use of risk-adapted therapeutic strategies for AL according to the Bcl-2 expression status." @default.
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• W2025839215 date "2014-01-24" @default.
• W2025839215 modified "2023-09-28" @default.
• W2025839215 title "Prognostic significance of B-cell lymphoma 2 expression in acute leukemia: A systematic review and meta-analysis" @default.
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• W2025839215 doi "https://doi.org/10.3892/mco.2014.248" @default.
• W2025839215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3999138" @default.
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