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- W2025852600 abstract "The current study was undertaken to investigate the effect of swimming training on the antioxidant enzyme system in kindney of young and old mice. Both young and old mice (n = 24), aged 2 and 26 months old, respectively, were divided into the sedentary and swimming-trained groups. The trained mice underwent a 6-w swimming program (1 h/day, 5 days/w) in water at 35 °C. Cu,Zn-superoxide dismutase (Cu.Zn-SOD) activity was significantly decreased with aging but was not influenced by swimming training, such changes being similar to those noted for catalase activity rather than for glutathione peroxidase activity. After swimming training Mn-SOD activity increased significantly only in old mice but was unaffected by aging. Although neither aging nor swimming training had overt effect on the expression of Cu,Zn-SOD mRNA, the immunoreactive Cu,Zn-SOD content in young mice decreased significantly after the training. Meanwhile, as shown in thefigure, the Mn-SOD mRNA expression in old mice was reduced by half after swimming training, accompanied by a significant decrease in its immunoreactive content; unexpectedly, however, the Mn-SOD content in young mice did not parallel its mRNA expression. These findings suggest that the antioxidant enzyme system in mouse kidney trends to be downregulated with aging, and that swimming training fails to attenuate such reduced levels of the antioxidant enzymes." @default.
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- W2025852600 date "1997-05-01" @default.
- W2025852600 modified "2023-09-25" @default.
- W2025852600 title "EFFECTS OF SWIMMING TRAINING ON ANTIOXIDANT ENZYMES IN KIDNEY OF YOUNG AND OLD MICE 1310" @default.
- W2025852600 doi "https://doi.org/10.1097/00005768-199705001-01308" @default.
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