FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025853810> ?p ?o ?g. }

• W2025853810 endingPage "44" @default.
• W2025853810 startingPage "36" @default.
• W2025853810 abstract "The majority of adenosine triphosphate (ATP)-induced nociceptive transduction and pain has been attributed to ionotropic P2X3 receptors. Metabotropic P2Y receptors, some of which bind pyrimidines as well as purines, have received little attention. Here we have examined the ability of P2Y receptor signaling to evoke action potential firing in functionally identified afferent fibers using the skin nerve preparation from adult mouse. The P2Y2/P2Y4 ligand UTP activated sustained action potential firing in 54% of C fibers in a concentration-dependent manner. The effect was specific for P2Y2/P2Y4 receptors, as the P2Y6 ligand UDP never activated C fibers. In comparison to C fibers, few thinly myelinated A-mechanoreceptors (AM) (12%) were activated by UTP. The majority (70–80%) of the UTP-sensitive C and Aδ fibers responded to the algogen capsaicin with a barrage of action potentials, whereas the UTP-insensitive fibers were largely unresponsive to capsaicin. Furthermore, 86% of the UTP-sensitive C fibers and 100% of the UTP-sensitive AM fibers also responded to the P2X agonist α,β-methylene ATP, indicating that P2Y and P2X receptors are widely co-expressed. Surprisingly, a significant proportion (20–40%) of low threshold slowly and rapidly adapting Aβ fibers were also activated by UTP and α,β-methylene ATP. These data indicate that P2Y receptors on the terminals of capsaicin-sensitive cutaneous sensory neurons effectively evoke nociceptive transmission, and support the hypothesis that UTP may be an endogenous nociceptive messenger. Furthermore, P2Y signaling may contribute to mechanotransduction in low threshold Aβ fibers under normal or pathological conditions." @default.
• W2025853810 created "2016-06-24" @default.
• W2025853810 creator A5008499445 @default.
• W2025853810 creator A5040894139 @default.
• W2025853810 creator A5088325043 @default.
• W2025853810 date "2004-05-01" @default.
• W2025853810 modified "2023-10-12" @default.
• W2025853810 title "The P2Y agonist UTP activates cutaneous afferent fibers" @default.
• W2025853810 cites W1498022804 @default.
• W2025853810 cites W1600528148 @default.
• W2025853810 cites W1623121663 @default.
• W2025853810 cites W1815264282 @default.
• W2025853810 cites W1862246641 @default.
• W2025853810 cites W1893308746 @default.
• W2025853810 cites W1902087884 @default.
• W2025853810 cites W1963792755 @default.
• W2025853810 cites W1980927246 @default.
• W2025853810 cites W1988231418 @default.
• W2025853810 cites W1992529363 @default.
• W2025853810 cites W1996980546 @default.
• W2025853810 cites W2000033837 @default.
• W2025853810 cites W2014683303 @default.
• W2025853810 cites W2015395924 @default.
• W2025853810 cites W2019957079 @default.
• W2025853810 cites W2020588358 @default.
• W2025853810 cites W2021311015 @default.
• W2025853810 cites W2029100084 @default.
• W2025853810 cites W2031039258 @default.
• W2025853810 cites W203575579 @default.
• W2025853810 cites W2039457863 @default.
• W2025853810 cites W2048201868 @default.
• W2025853810 cites W2056882527 @default.
• W2025853810 cites W2057216006 @default.
• W2025853810 cites W2069004519 @default.
• W2025853810 cites W2070300420 @default.
• W2025853810 cites W2083457444 @default.
• W2025853810 cites W2084701217 @default.
• W2025853810 cites W2090813510 @default.
• W2025853810 cites W2091539852 @default.
• W2025853810 cites W2091991131 @default.
• W2025853810 cites W2095062283 @default.
• W2025853810 cites W2095114372 @default.
• W2025853810 cites W2104661115 @default.
• W2025853810 cites W2109138542 @default.
• W2025853810 cites W2135087145 @default.
• W2025853810 cites W2142926248 @default.
• W2025853810 cites W2160876060 @default.
• W2025853810 cites W2168625138 @default.
• W2025853810 cites W95383497 @default.
• W2025853810 doi "https://doi.org/10.1016/j.pain.2004.01.007" @default.
• W2025853810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15082124" @default.
• W2025853810 hasPublicationYear "2004" @default.
• W2025853810 type Work @default.
• W2025853810 sameAs 2025853810 @default.
• W2025853810 citedByCount "74" @default.
• W2025853810 countsByYear W20258538102012 @default.
• W2025853810 countsByYear W20258538102013 @default.
• W2025853810 countsByYear W20258538102014 @default.
• W2025853810 countsByYear W20258538102015 @default.
• W2025853810 countsByYear W20258538102016 @default.
• W2025853810 countsByYear W20258538102018 @default.
• W2025853810 countsByYear W20258538102021 @default.
• W2025853810 countsByYear W20258538102022 @default.
• W2025853810 countsByYear W20258538102023 @default.
• W2025853810 crossrefType "journal-article" @default.
• W2025853810 hasAuthorship W2025853810A5008499445 @default.
• W2025853810 hasAuthorship W2025853810A5040894139 @default.
• W2025853810 hasAuthorship W2025853810A5088325043 @default.
• W2025853810 hasConcept C115955781 @default.
• W2025853810 hasConcept C15490471 @default.
• W2025853810 hasConcept C160225129 @default.
• W2025853810 hasConcept C170493617 @default.
• W2025853810 hasConcept C172659308 @default.
• W2025853810 hasConcept C185592680 @default.
• W2025853810 hasConcept C26702167 @default.
• W2025853810 hasConcept C2778938600 @default.
• W2025853810 hasConcept C2780019924 @default.
• W2025853810 hasConcept C2780051329 @default.
• W2025853810 hasConcept C2780410667 @default.
• W2025853810 hasConcept C55493867 @default.
• W2025853810 hasConcept C57306754 @default.
• W2025853810 hasConcept C61174792 @default.
• W2025853810 hasConcept C86803240 @default.
• W2025853810 hasConcept C95444343 @default.
• W2025853810 hasConceptScore W2025853810C115955781 @default.
• W2025853810 hasConceptScore W2025853810C15490471 @default.
• W2025853810 hasConceptScore W2025853810C160225129 @default.
• W2025853810 hasConceptScore W2025853810C170493617 @default.
• W2025853810 hasConceptScore W2025853810C172659308 @default.
• W2025853810 hasConceptScore W2025853810C185592680 @default.
• W2025853810 hasConceptScore W2025853810C26702167 @default.
• W2025853810 hasConceptScore W2025853810C2778938600 @default.
• W2025853810 hasConceptScore W2025853810C2780019924 @default.
• W2025853810 hasConceptScore W2025853810C2780051329 @default.
• W2025853810 hasConceptScore W2025853810C2780410667 @default.
• W2025853810 hasConceptScore W2025853810C55493867 @default.
• W2025853810 hasConceptScore W2025853810C57306754 @default.
• W2025853810 hasConceptScore W2025853810C61174792 @default.

• next