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• W2025857570 abstract "The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemistry. In the early stages of T1 and T2 (38 cases), VEGF-C expression strongly correlated with lymph node metastasis (P < 0.001), and the percentage of VEGF-C-positive staining was 88.2% for patients with lymph node metastasis (15 of 17 cases) and 28.6% for those without lymph node metastasis (6 of 21 cases). However, in the advanced stages of T3 and T4, no significant correlation between VEGF-C expression and lymph node metastasis was observed. These results indicate that VEGF-C expression in biopsy specimens can be used as a reliable predictor of regional lymph node metastasis, particularly in early OSCC, and may become an important factor in the selection of appropriate treatment." @default.
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• W2025857570 date "2003-06-01" @default.
• W2025857570 modified "2023-09-27" @default.
• W2025857570 title "Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma" @default.
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• W2025857570 doi "https://doi.org/10.1016/s1368-8375(02)00143-4" @default.
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