Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025871844> ?p ?o ?g. }
- W2025871844 endingPage "1175" @default.
- W2025871844 startingPage "1167" @default.
- W2025871844 abstract "BackgroundNeuropeptides regulate many biological processes. Elucidation of neuropeptide function requires identifying the cells that respond to neuropeptide signals and determining the molecular, cellular, physiological, and behavioral consequences of activation of their cognate G protein-coupled receptors (GPCRs) in those cells. As a novel tool for addressing such issues, we have developed genetically encoded neuropeptides covalently tethered to a glycosylphosphatidylinositol (GPI) glycolipid anchor on the plasma membrane (“t-peptides”).Resultst-peptides cell-autonomously induce activation of their cognate GPCRs in cells that express both the t-peptide and its receptor. In the neural circuit controlling circadian rest-activity rhythms in Drosophila melanogaster, rhythmic secretion of the neuropeptide pigment-dispersing factor (PDF) and activation of its GPCR (PDFR) are important for intercellular communication of phase information and coordination of clock neuron oscillation. Broad expression of t-PDF in the circadian control circuit overcomes arrhythmicity induced by pdf01 null mutation, most likely as a result of activation of PDFR in PDFR-expressing clock neurons that do not themselves secrete PDF. More restricted expression of t-PDF suggests that activation of PDFR accelerates cellular timekeeping in some clock neurons while decelerating others.ConclusionsThe activation of PDFR in pdf01 null mutant flies—which lack PDF-mediated intercellular transfer of phase information—induces strong rhythmicity in constant darkness, thus establishing a distinct role for PDF signaling in the circadian control circuit independent of the intercellular communication of temporal phase information. The t-peptide technology should provide a useful tool for cellular dissection of bioactive peptide signaling in a variety of organisms and physiological contexts." @default.
- W2025871844 created "2016-06-24" @default.
- W2025871844 creator A5038110885 @default.
- W2025871844 creator A5043531661 @default.
- W2025871844 creator A5059103090 @default.
- W2025871844 creator A5070123450 @default.
- W2025871844 creator A5072443724 @default.
- W2025871844 creator A5082620506 @default.
- W2025871844 date "2009-07-01" @default.
- W2025871844 modified "2023-10-14" @default.
- W2025871844 title "Cellular Dissection of Circadian Peptide Signals with Genetically Encoded Membrane-Tethered Ligands" @default.
- W2025871844 cites W1971442608 @default.
- W2025871844 cites W1972196661 @default.
- W2025871844 cites W1973425065 @default.
- W2025871844 cites W1976734037 @default.
- W2025871844 cites W1986877101 @default.
- W2025871844 cites W1991279445 @default.
- W2025871844 cites W1999163244 @default.
- W2025871844 cites W2000408299 @default.
- W2025871844 cites W2003083502 @default.
- W2025871844 cites W2012060696 @default.
- W2025871844 cites W2021500478 @default.
- W2025871844 cites W2023008210 @default.
- W2025871844 cites W2023831182 @default.
- W2025871844 cites W2026287338 @default.
- W2025871844 cites W2046587067 @default.
- W2025871844 cites W2056240302 @default.
- W2025871844 cites W2058947907 @default.
- W2025871844 cites W2069102506 @default.
- W2025871844 cites W2071250433 @default.
- W2025871844 cites W2074591242 @default.
- W2025871844 cites W2076215193 @default.
- W2025871844 cites W2077406857 @default.
- W2025871844 cites W2078063564 @default.
- W2025871844 cites W2079883670 @default.
- W2025871844 cites W2089762138 @default.
- W2025871844 cites W2099041385 @default.
- W2025871844 cites W2103144141 @default.
- W2025871844 cites W2104746647 @default.
- W2025871844 cites W2110643873 @default.
- W2025871844 cites W2113526393 @default.
- W2025871844 cites W2127186571 @default.
- W2025871844 cites W2133260119 @default.
- W2025871844 cites W2140501120 @default.
- W2025871844 cites W2140779941 @default.
- W2025871844 cites W2142846515 @default.
- W2025871844 cites W2144071975 @default.
- W2025871844 cites W2159255304 @default.
- W2025871844 cites W2169137344 @default.
- W2025871844 cites W4321429277 @default.
- W2025871844 doi "https://doi.org/10.1016/j.cub.2009.06.029" @default.
- W2025871844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2719018" @default.
- W2025871844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19592252" @default.
- W2025871844 hasPublicationYear "2009" @default.
- W2025871844 type Work @default.
- W2025871844 sameAs 2025871844 @default.
- W2025871844 citedByCount "68" @default.
- W2025871844 countsByYear W20258718442012 @default.
- W2025871844 countsByYear W20258718442013 @default.
- W2025871844 countsByYear W20258718442014 @default.
- W2025871844 countsByYear W20258718442016 @default.
- W2025871844 countsByYear W20258718442017 @default.
- W2025871844 countsByYear W20258718442018 @default.
- W2025871844 countsByYear W20258718442019 @default.
- W2025871844 countsByYear W20258718442020 @default.
- W2025871844 countsByYear W20258718442021 @default.
- W2025871844 countsByYear W20258718442022 @default.
- W2025871844 countsByYear W20258718442023 @default.
- W2025871844 crossrefType "journal-article" @default.
- W2025871844 hasAuthorship W2025871844A5038110885 @default.
- W2025871844 hasAuthorship W2025871844A5043531661 @default.
- W2025871844 hasAuthorship W2025871844A5059103090 @default.
- W2025871844 hasAuthorship W2025871844A5070123450 @default.
- W2025871844 hasAuthorship W2025871844A5072443724 @default.
- W2025871844 hasAuthorship W2025871844A5082620506 @default.
- W2025871844 hasBestOaLocation W20258718441 @default.
- W2025871844 hasConcept C104317684 @default.
- W2025871844 hasConcept C118303440 @default.
- W2025871844 hasConcept C121446783 @default.
- W2025871844 hasConcept C135285700 @default.
- W2025871844 hasConcept C169760540 @default.
- W2025871844 hasConcept C170493617 @default.
- W2025871844 hasConcept C2780104201 @default.
- W2025871844 hasConcept C38606739 @default.
- W2025871844 hasConcept C49039625 @default.
- W2025871844 hasConcept C55493867 @default.
- W2025871844 hasConcept C62478195 @default.
- W2025871844 hasConcept C79879829 @default.
- W2025871844 hasConcept C86803240 @default.
- W2025871844 hasConcept C95444343 @default.
- W2025871844 hasConceptScore W2025871844C104317684 @default.
- W2025871844 hasConceptScore W2025871844C118303440 @default.
- W2025871844 hasConceptScore W2025871844C121446783 @default.
- W2025871844 hasConceptScore W2025871844C135285700 @default.
- W2025871844 hasConceptScore W2025871844C169760540 @default.
- W2025871844 hasConceptScore W2025871844C170493617 @default.
- W2025871844 hasConceptScore W2025871844C2780104201 @default.
- W2025871844 hasConceptScore W2025871844C38606739 @default.