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• W2025881104 abstract "The activation of placental AC by either Mg 2+ or Mn 2+ , in the presence and absence of NaF, followed sigmoidal saturation kinetics. Mn 2+ enhanced maximally the NaF-stimulated Mg 2+ -dependent AC activity. The apparent K m of Mg 2+ -dependent AC for ATP was 0.4 m M , with and without NaF addition. GTP and GMP-P(NH)P stimulated the Mg 2+ -dependent AC in a dose-dependent manner with half-maximal stimulation taking place at concentrations of approximately 2 μM. In the presence of GMP-P(NH)P (10 μm) the kinetics of the AC dependence on Mg + ion concentration changed from sigmoidal to hyperbolic. Most of the AC activity (> 83 per cent) was associated with the particulate fractions of placental homogenate. For better reproducibility, the AC assay was performed using sonicated particulate fraction preparations; sonication did not alter the response of AC to stimuli to a variety of agents used in these experiments; freezing and thawing, however, obliterated the stimulation by β-adrenergic agonists. Placental AC activity was inhibited by p -hydroxymercuriphenyl sodium sulphonate in a dose-dependent fashion, and the inhibition was reversed by dithiothreitol. Mg 2+ -dependent AC was inhibited by 0.5 mm phenylhydrazine (95 per cent). Mg 2+ -dependent AC activity was responsive to stimulation by epinephrine, without and with GTP addition, with half-maximal stimulation taking place at a concentration of 2 μm. The stimulatory effect of epinephrine was blocked by propranolol in a dose-dependent manner but was not blocked by phentolamine. Oestrone, oestradiol-17β, 2-hydroxyoestreone, 2-hydroxyoestradiol-17β, dehydroepiandrosterone sulphate, and progesterone, as well as oxytocin, did not alter either the basal or GMP-P(NH)P-stimulated Mg 2+ -dependent AC activities. Preincubation of 20 000 g particulate fraction with either NaF or GMP-P(NH)P, followed by washing, resulted in preparations that remained stimulated without the requirement of any further additions." @default.
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• W2025881104 date "1982-01-01" @default.
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• W2025881104 title "Adenylate cyclase from term human placenta and its regulation" @default.
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• W2025881104 doi "https://doi.org/10.1016/s0143-4004(82)80050-7" @default.
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