FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025884076> ?p ?o ?g. }

• W2025884076 endingPage "73" @default.
• W2025884076 startingPage "61" @default.
• W2025884076 abstract "Growth factor receptors such as the epidermal growth factor receptor (EGFR) and the p185c-neu protein serve vital roles in the transduction of differentiation, developmental, or mitogenic signaling within normal cells. Two methods of analysis suggest that the inappropriately high expression of either protein tyrosine kinase promotes malignant transformation. First, data from in vitro experiments indicate that overexpression of either EGFR or p185c-neu (or the human homolog c-erbB-2) transforms cell-lines. Second, analysis of primary tumors and tumor cell-lines derived from many epithelial tissues (breast, stomach, ovary, and pancreas) show growth factor receptor gene amplification and elevated protein levels. The physical and functional interaction of p185c-neu and EGFR leads to the formation of a highly active, heterodimeric tyrosine kinase complex which synergistically activates cellular transformation. Anti-receptor antibodies have shown potential utility for the down modulation of these cell-surface proteins and suppression of the malignant phenotype. Design of organic antibody mimetics based on the structure of antireceptor antibodies may provide useful therapies and biological reagents to affect growth factor receptor function." @default.
• W2025884076 created "2016-06-24" @default.
• W2025884076 creator A5042586488 @default.
• W2025884076 creator A5044848608 @default.
• W2025884076 creator A5091416723 @default.
• W2025884076 date "1993-09-01" @default.
• W2025884076 modified "2023-10-05" @default.
• W2025884076 title "Interaction of the neu/p185 and EGF receptor tyrosine kinases: Implications for cellular transformation and tumor therapy" @default.
• W2025884076 cites W1495563488 @default.
• W2025884076 cites W1553254670 @default.
• W2025884076 cites W1574013273 @default.
• W2025884076 cites W158850611 @default.
• W2025884076 cites W1634552148 @default.
• W2025884076 cites W1745189793 @default.
• W2025884076 cites W1785797482 @default.
• W2025884076 cites W1963804483 @default.
• W2025884076 cites W1966823692 @default.
• W2025884076 cites W1977958044 @default.
• W2025884076 cites W1979443682 @default.
• W2025884076 cites W1983673751 @default.
• W2025884076 cites W1991766587 @default.
• W2025884076 cites W1992221703 @default.
• W2025884076 cites W1999265691 @default.
• W2025884076 cites W2001627828 @default.
• W2025884076 cites W2002530645 @default.
• W2025884076 cites W2017114220 @default.
• W2025884076 cites W2017969102 @default.
• W2025884076 cites W2019401962 @default.
• W2025884076 cites W2021538232 @default.
• W2025884076 cites W2028387622 @default.
• W2025884076 cites W2032359283 @default.
• W2025884076 cites W2042051621 @default.
• W2025884076 cites W2042169992 @default.
• W2025884076 cites W2043711125 @default.
• W2025884076 cites W2046439112 @default.
• W2025884076 cites W2049057488 @default.
• W2025884076 cites W2054858544 @default.
• W2025884076 cites W2080645865 @default.
• W2025884076 cites W2082431893 @default.
• W2025884076 cites W2085665257 @default.
• W2025884076 cites W2088054041 @default.
• W2025884076 cites W2095156669 @default.
• W2025884076 cites W2095483608 @default.
• W2025884076 cites W2120945020 @default.
• W2025884076 cites W2121997189 @default.
• W2025884076 cites W2139397808 @default.
• W2025884076 cites W2149051154 @default.
• W2025884076 cites W2170016411 @default.
• W2025884076 cites W4247920049 @default.
• W2025884076 doi "https://doi.org/10.1002/jcb.240530108" @default.
• W2025884076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7901229" @default.
• W2025884076 hasPublicationYear "1993" @default.
• W2025884076 type Work @default.
• W2025884076 sameAs 2025884076 @default.
• W2025884076 citedByCount "73" @default.
• W2025884076 countsByYear W20258840762012 @default.
• W2025884076 countsByYear W20258840762013 @default.
• W2025884076 countsByYear W20258840762016 @default.
• W2025884076 crossrefType "journal-article" @default.
• W2025884076 hasAuthorship W2025884076A5042586488 @default.
• W2025884076 hasAuthorship W2025884076A5044848608 @default.
• W2025884076 hasAuthorship W2025884076A5091416723 @default.
• W2025884076 hasConcept C101544691 @default.
• W2025884076 hasConcept C170493617 @default.
• W2025884076 hasConcept C197462201 @default.
• W2025884076 hasConcept C26375932 @default.
• W2025884076 hasConcept C2776362946 @default.
• W2025884076 hasConcept C2779251935 @default.
• W2025884076 hasConcept C2779438470 @default.
• W2025884076 hasConcept C42362537 @default.
• W2025884076 hasConcept C502942594 @default.
• W2025884076 hasConcept C55493867 @default.
• W2025884076 hasConcept C62478195 @default.
• W2025884076 hasConcept C86803240 @default.
• W2025884076 hasConcept C95444343 @default.
• W2025884076 hasConceptScore W2025884076C101544691 @default.
• W2025884076 hasConceptScore W2025884076C170493617 @default.
• W2025884076 hasConceptScore W2025884076C197462201 @default.
• W2025884076 hasConceptScore W2025884076C26375932 @default.
• W2025884076 hasConceptScore W2025884076C2776362946 @default.
• W2025884076 hasConceptScore W2025884076C2779251935 @default.
• W2025884076 hasConceptScore W2025884076C2779438470 @default.
• W2025884076 hasConceptScore W2025884076C42362537 @default.
• W2025884076 hasConceptScore W2025884076C502942594 @default.
• W2025884076 hasConceptScore W2025884076C55493867 @default.
• W2025884076 hasConceptScore W2025884076C62478195 @default.
• W2025884076 hasConceptScore W2025884076C86803240 @default.
• W2025884076 hasConceptScore W2025884076C95444343 @default.
• W2025884076 hasIssue "1" @default.
• W2025884076 hasLocation W20258840761 @default.
• W2025884076 hasLocation W20258840762 @default.
• W2025884076 hasOpenAccess W2025884076 @default.
• W2025884076 hasPrimaryLocation W20258840761 @default.
• W2025884076 hasRelatedWork W153749366 @default.
• W2025884076 hasRelatedWork W1751697891 @default.
• W2025884076 hasRelatedWork W1765059066 @default.
• W2025884076 hasRelatedWork W2007649418 @default.
• W2025884076 hasRelatedWork W2009437679 @default.

• next