FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025891985> ?p ?o ?g. }

• W2025891985 endingPage "1601" @default.
• W2025891985 startingPage "1593" @default.
• W2025891985 abstract "NG-monomethylarginine (L-NMA) and asymmetric NG, NG-dimethylarginines (ADMA) are endogenous inhibitors of cellular L-arginine uptake and/or nitric oxide (NO) synthesis that are implicated in renal parenchymal and Dahl salt-sensitive hypertension. Since the L-arginine:(L-NMA + ADMA) ratio determines NO synthase (NOS) activity, we compared the immunohistochemical distribution of NOS with NG, NG-dimethylarginine dimethylaminohydrolase (DDAH), which inactivates dimethylarginines (DMA) and L-NMA by hydrolysis to L-citrulline. Neuronal NOS (nNOS) was expressed predominantly in tubular epithelial cells of macula densa (MD), endothelial NOS (eNOS) in vascular endothelial cells (EC), and inducible NOS (iNOS) quite widely in tubular epithelium, including proximal tubules (PT), thick ascending limbs of Henle (TAL), distal convoluted tubule and intercalated cells (IC) of the collecting duct. Immunostaining for DDAH was present in PT, TAL, MD, and IC, and was also present in the glomerulus, Bowman's capsule, and endothelium of blood vessels. DDAH was detected in small vesicles of TAL and PT by electron microscopic (EM) immunocytochemistry. To study the effects of methylarginines on tubuloglomerular feedback (TGF) response, vehicle or methylarginines (10(-3) M) were added to artificial tubular fluid (ATF) perfused orthogradely from the late PT at 40 nl. min-1 while assessing changes in glomerular capillary pressure from proximal stop flow pressure (PSF). Whereas the maximal TGF responses were unchanged by vehicle (delta TGF 0 +/- 0%) or symmetric DMA (SDMA; +1 +/- 2%, NS), they were enhanced by L-NMA (+22 +/- 4%, P < 0.001) and asymmetric DMA (ADMA; +28 +/- 3%, P < 0.001). Since L-arginine transport can regulate renal epithelial NO generation, methylarginines (10(-3) M) or vehicle were co-perfused orthogradely with [3H]-L-arginine from the late PT and collected at the early distal tubule to study arginine uptake from the perfused loop of Henle. All methylarginines reduced fractional loop [3H] absorption significantly (P < 0.001; vehicle, 84 +/- 6; ADMA, 49 +/- 6; SDMA, 56 +/- 6; L-NMA, 41 +/- 6%). In conclusion, sites of DDAH expression in the vasculature or nephron are all sites of expression of an isoform of NOS. L-NMA, ADMA, and SDMA all inhibit renal tubular L-arginine uptake, whereas L-NMA and ADMA, but not SDMA, enhance TGF responses. Therefore, DDAH may regulate the cellular L-arginine: methylarginine levels in specific renal cells, thereby governing cell-specific L-arginine uptake and NO generation in renal tubular epithelium." @default.
• W2025891985 created "2016-06-24" @default.
• W2025891985 creator A5009162758 @default.
• W2025891985 creator A5034244372 @default.
• W2025891985 creator A5043650697 @default.
• W2025891985 creator A5044921310 @default.
• W2025891985 creator A5062841581 @default.
• W2025891985 creator A5065897620 @default.
• W2025891985 creator A5070628886 @default.
• W2025891985 creator A5073267685 @default.
• W2025891985 creator A5086410506 @default.
• W2025891985 date "1997-12-01" @default.
• W2025891985 modified "2023-09-30" @default.
• W2025891985 title "Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney" @default.
• W2025891985 cites W1583601846 @default.
• W2025891985 cites W1923660451 @default.
• W2025891985 cites W1965294836 @default.
• W2025891985 cites W1965474388 @default.
• W2025891985 cites W1965688452 @default.
• W2025891985 cites W1969130635 @default.
• W2025891985 cites W1970972047 @default.
• W2025891985 cites W1975896607 @default.
• W2025891985 cites W1997640957 @default.
• W2025891985 cites W2000806054 @default.
• W2025891985 cites W2007361075 @default.
• W2025891985 cites W2010707246 @default.
• W2025891985 cites W2024919412 @default.
• W2025891985 cites W2029094496 @default.
• W2025891985 cites W2034134123 @default.
• W2025891985 cites W2055133610 @default.
• W2025891985 cites W2056103165 @default.
• W2025891985 cites W2058385357 @default.
• W2025891985 cites W2073133399 @default.
• W2025891985 cites W2091121269 @default.
• W2025891985 cites W2120964284 @default.
• W2025891985 cites W2123706039 @default.
• W2025891985 cites W2124942654 @default.
• W2025891985 cites W2131746045 @default.
• W2025891985 cites W2161887334 @default.
• W2025891985 cites W2165846827 @default.
• W2025891985 cites W2295637372 @default.
• W2025891985 cites W2317196764 @default.
• W2025891985 cites W2418902421 @default.
• W2025891985 cites W78580968 @default.
• W2025891985 doi "https://doi.org/10.1038/ki.1997.490" @default.
• W2025891985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9407505" @default.
• W2025891985 hasPublicationYear "1997" @default.
• W2025891985 type Work @default.
• W2025891985 sameAs 2025891985 @default.
• W2025891985 citedByCount "189" @default.
• W2025891985 countsByYear W20258919852012 @default.
• W2025891985 countsByYear W20258919852013 @default.
• W2025891985 countsByYear W20258919852014 @default.
• W2025891985 countsByYear W20258919852015 @default.
• W2025891985 countsByYear W20258919852016 @default.
• W2025891985 countsByYear W20258919852017 @default.
• W2025891985 countsByYear W20258919852018 @default.
• W2025891985 countsByYear W20258919852019 @default.
• W2025891985 countsByYear W20258919852020 @default.
• W2025891985 countsByYear W20258919852021 @default.
• W2025891985 countsByYear W20258919852022 @default.
• W2025891985 countsByYear W20258919852023 @default.
• W2025891985 crossrefType "journal-article" @default.
• W2025891985 hasAuthorship W2025891985A5009162758 @default.
• W2025891985 hasAuthorship W2025891985A5034244372 @default.
• W2025891985 hasAuthorship W2025891985A5043650697 @default.
• W2025891985 hasAuthorship W2025891985A5044921310 @default.
• W2025891985 hasAuthorship W2025891985A5062841581 @default.
• W2025891985 hasAuthorship W2025891985A5065897620 @default.
• W2025891985 hasAuthorship W2025891985A5070628886 @default.
• W2025891985 hasAuthorship W2025891985A5073267685 @default.
• W2025891985 hasAuthorship W2025891985A5086410506 @default.
• W2025891985 hasBestOaLocation W20258919851 @default.
• W2025891985 hasConcept C126322002 @default.
• W2025891985 hasConcept C134018914 @default.
• W2025891985 hasConcept C153911025 @default.
• W2025891985 hasConcept C185592680 @default.
• W2025891985 hasConcept C198710026 @default.
• W2025891985 hasConcept C204232928 @default.
• W2025891985 hasConcept C2776844834 @default.
• W2025891985 hasConcept C2776992346 @default.
• W2025891985 hasConcept C2777468819 @default.
• W2025891985 hasConcept C2777622882 @default.
• W2025891985 hasConcept C2778326061 @default.
• W2025891985 hasConcept C2779698670 @default.
• W2025891985 hasConcept C2779877776 @default.
• W2025891985 hasConcept C2780091579 @default.
• W2025891985 hasConcept C2781231759 @default.
• W2025891985 hasConcept C2781236342 @default.
• W2025891985 hasConcept C35866371 @default.
• W2025891985 hasConcept C40209533 @default.
• W2025891985 hasConcept C4224716 @default.
• W2025891985 hasConcept C515207424 @default.
• W2025891985 hasConcept C519581460 @default.
• W2025891985 hasConcept C55493867 @default.
• W2025891985 hasConcept C71924100 @default.
• W2025891985 hasConcept C7643261 @default.
• W2025891985 hasConcept C84393581 @default.

• next