Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025909145> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2025909145 endingPage "243" @default.
- W2025909145 startingPage "235" @default.
- W2025909145 abstract "In view of the known effects of Cortisol and related compounds on sodium balance, we examined leucocyte 22Na+ efflux in patients with adrenocortical insufficiency. The ouabain-sensitive 22Na+ efflux rate constant, which reflects sodium pump activity, was lowered in secondary hypoadrenalism (mean 1.95 ± SD 0.25 vs 2.33 ± 0.45 h-1, P< 0.002, n= 6). Patients with hypoadrenalism also had higher intracellular sodium content (mean 34.9 ± SD 3.5 vs 27.8 ± 9.5 mmol/kg dry weight, P< 0.008) and lower intracellular potassium to sodium ratios (mean 9.7 ± SD 0.7 vs 12.9 ± 3.6, P<0.001). These defects in cellular sodium balance were corrected following replacement therapy with Cortisol, prednisolone or dexamethasone. In-vitro incubation of normal leucocytes with 5-20 nmol/1 dexamethasone led to an increase in the Na+/K+-ATPase activity. The effect of Cortisol and related compounds on the distribution of sodium between intra- and extra-cellular fluid may be mediated by their action on the sodium pump." @default.
- W2025909145 created "2016-06-24" @default.
- W2025909145 creator A5016174230 @default.
- W2025909145 creator A5047407441 @default.
- W2025909145 creator A5091305818 @default.
- W2025909145 date "1987-08-01" @default.
- W2025909145 modified "2023-10-04" @default.
- W2025909145 title "THE HUMAN LEUCOCYTE SODIUM PUMP IN ADRENOCORTICAL INSUFFICIENCY" @default.
- W2025909145 cites W1975618645 @default.
- W2025909145 cites W1994607497 @default.
- W2025909145 cites W2026445883 @default.
- W2025909145 cites W2026976157 @default.
- W2025909145 cites W2037200941 @default.
- W2025909145 cites W2089593630 @default.
- W2025909145 cites W2121747315 @default.
- W2025909145 cites W2128635872 @default.
- W2025909145 cites W2312536696 @default.
- W2025909145 cites W2324626111 @default.
- W2025909145 cites W2343306041 @default.
- W2025909145 cites W2401011336 @default.
- W2025909145 cites W2404866741 @default.
- W2025909145 cites W2408716012 @default.
- W2025909145 cites W2409741355 @default.
- W2025909145 cites W2410981063 @default.
- W2025909145 cites W2413128167 @default.
- W2025909145 cites W2604788475 @default.
- W2025909145 doi "https://doi.org/10.1111/j.1365-2265.1987.tb01149.x" @default.
- W2025909145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3665131" @default.
- W2025909145 hasPublicationYear "1987" @default.
- W2025909145 type Work @default.
- W2025909145 sameAs 2025909145 @default.
- W2025909145 citedByCount "4" @default.
- W2025909145 crossrefType "journal-article" @default.
- W2025909145 hasAuthorship W2025909145A5016174230 @default.
- W2025909145 hasAuthorship W2025909145A5047407441 @default.
- W2025909145 hasAuthorship W2025909145A5091305818 @default.
- W2025909145 hasConcept C126322002 @default.
- W2025909145 hasConcept C134018914 @default.
- W2025909145 hasConcept C178790620 @default.
- W2025909145 hasConcept C185592680 @default.
- W2025909145 hasConcept C200082930 @default.
- W2025909145 hasConcept C202751555 @default.
- W2025909145 hasConcept C25642318 @default.
- W2025909145 hasConcept C2778129406 @default.
- W2025909145 hasConcept C2779133857 @default.
- W2025909145 hasConcept C2780401358 @default.
- W2025909145 hasConcept C2780841215 @default.
- W2025909145 hasConcept C2909038281 @default.
- W2025909145 hasConcept C517785266 @default.
- W2025909145 hasConcept C537181965 @default.
- W2025909145 hasConcept C55493867 @default.
- W2025909145 hasConcept C71924100 @default.
- W2025909145 hasConcept C79879829 @default.
- W2025909145 hasConceptScore W2025909145C126322002 @default.
- W2025909145 hasConceptScore W2025909145C134018914 @default.
- W2025909145 hasConceptScore W2025909145C178790620 @default.
- W2025909145 hasConceptScore W2025909145C185592680 @default.
- W2025909145 hasConceptScore W2025909145C200082930 @default.
- W2025909145 hasConceptScore W2025909145C202751555 @default.
- W2025909145 hasConceptScore W2025909145C25642318 @default.
- W2025909145 hasConceptScore W2025909145C2778129406 @default.
- W2025909145 hasConceptScore W2025909145C2779133857 @default.
- W2025909145 hasConceptScore W2025909145C2780401358 @default.
- W2025909145 hasConceptScore W2025909145C2780841215 @default.
- W2025909145 hasConceptScore W2025909145C2909038281 @default.
- W2025909145 hasConceptScore W2025909145C517785266 @default.
- W2025909145 hasConceptScore W2025909145C537181965 @default.
- W2025909145 hasConceptScore W2025909145C55493867 @default.
- W2025909145 hasConceptScore W2025909145C71924100 @default.
- W2025909145 hasConceptScore W2025909145C79879829 @default.
- W2025909145 hasIssue "2" @default.
- W2025909145 hasLocation W20259091451 @default.
- W2025909145 hasLocation W20259091452 @default.
- W2025909145 hasOpenAccess W2025909145 @default.
- W2025909145 hasPrimaryLocation W20259091451 @default.
- W2025909145 hasRelatedWork W1970091690 @default.
- W2025909145 hasRelatedWork W1976035881 @default.
- W2025909145 hasRelatedWork W2002961347 @default.
- W2025909145 hasRelatedWork W2006238353 @default.
- W2025909145 hasRelatedWork W2009659059 @default.
- W2025909145 hasRelatedWork W2091746893 @default.
- W2025909145 hasRelatedWork W2141448367 @default.
- W2025909145 hasRelatedWork W2312051945 @default.
- W2025909145 hasRelatedWork W2415730563 @default.
- W2025909145 hasRelatedWork W2438146026 @default.
- W2025909145 hasVolume "27" @default.
- W2025909145 isParatext "false" @default.
- W2025909145 isRetracted "false" @default.
- W2025909145 magId "2025909145" @default.
- W2025909145 workType "article" @default.