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- W2025931439 abstract "In this study it was found that resting granulocytes from patients with rheumatoid arthritis (RA) who were treated with NSAID and from healthy volunteers do not differ in their basic cAMP concentration. The intracellular increase of cAMP caused by the action of the enzyme adenylate cyclase began immediately after contact with the opsonized particles and reached its peak concentration after approximately one minute. Opsonization of zymosan with rabbit complement in contrast to latex particles caused a 2,5-fold enhancement of the cAMP concentration. The use of sera from RA patients as an opsonizing medium for zymosan did not produce significantly different results from those using rabbit complement. The prompt appearance and rapid increase in concentration of the cyclic nucleotide after contact of the granulocytes with the opsonized particles shows the importance of cAMP for the phagocytic process." @default.
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- W2025931439 date "1987-05-01" @default.
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- W2025931439 title "Untersuchung über den cAMP-Gehalt von Granulozyten bei der chronischen Polyarthritis und die Änderung während der Phagozytose" @default.
- W2025931439 doi "https://doi.org/10.1055/s-2008-1047927" @default.
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