FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025931567> ?p ?o ?g. }

• W2025931567 endingPage "1511" @default.
• W2025931567 startingPage "1495" @default.
• W2025931567 abstract "Free ammonium ions are produced and consumed during cell metabolism. Glutamine synthetase utilizes free ammonium ions to produce glutamine in the cytosol whereas glutaminase and glutamate dehydrogenase generate free ammonium ions in the mitochondria from glutamine and glutamate, respectively. Ammonia and bicarbonate are condensed in the liver mitochondria to yield carbamoylphosphate initiating the urea cycle, the major mechanism of ammonium removal in humans. Healthy kidney produces ammonium which may be released into the systemic circulation or excreted into the urine depending predominantly on acid-base status, so that metabolic acidosis increases urinary ammonium excretion while metabolic alkalosis induces the opposite effect. Brain and skeletal muscle neither remove nor produce ammonium in normal conditions, but they are able to seize ammonium during hyperammonemia, releasing glutamine. Ammonia in gas phase has been detected in exhaled breath and skin, denoting that these organs may participate in nitrogen elimination. Ammonium homeostasis is profoundly altered in liver failure resulting in hyperammonemia due to the deficient ammonium clearance by the diseased liver and to the development of portal collateral circulation that diverts portal blood with high ammonium content to the systemic blood stream. Although blood ammonium concentration is usually elevated in liver disease, a substantial role of ammonium causing hepatic encephalopathy has not been demonstrated in human clinical studies. Hyperammonemia is also produced in urea cycle disorders and other situations leading to either defective ammonium removal or overproduction of ammonium that overcomes liver clearance capacity. Most diseases resulting in hyperammonemia and cerebral edema are preceded by hyperventilation and respiratory alkalosis of unclear origin that may be caused by the intracellular acidosis occurring in these conditions." @default.
• W2025931567 created "2016-06-24" @default.
• W2025931567 creator A5031330863 @default.
• W2025931567 creator A5035650176 @default.
• W2025931567 creator A5065188371 @default.
• W2025931567 creator A5079281626 @default.
• W2025931567 date "2012-11-01" @default.
• W2025931567 modified "2023-10-03" @default.
• W2025931567 title "Ammonium metabolism in humans" @default.
• W2025931567 cites W137360525 @default.
• W2025931567 cites W1485962729 @default.
• W2025931567 cites W1501875517 @default.
• W2025931567 cites W1521348142 @default.
• W2025931567 cites W152468297 @default.
• W2025931567 cites W1608208977 @default.
• W2025931567 cites W1608709490 @default.
• W2025931567 cites W1777642299 @default.
• W2025931567 cites W1821905173 @default.
• W2025931567 cites W1948390248 @default.
• W2025931567 cites W1963959444 @default.
• W2025931567 cites W1964562854 @default.
• W2025931567 cites W1964916639 @default.
• W2025931567 cites W1968443101 @default.
• W2025931567 cites W1968539407 @default.
• W2025931567 cites W1970363190 @default.
• W2025931567 cites W1970626473 @default.
• W2025931567 cites W1972310537 @default.
• W2025931567 cites W1973874949 @default.
• W2025931567 cites W1977374336 @default.
• W2025931567 cites W1978054795 @default.
• W2025931567 cites W1978523851 @default.
• W2025931567 cites W1979486195 @default.
• W2025931567 cites W1979711855 @default.
• W2025931567 cites W1981296999 @default.
• W2025931567 cites W1981700221 @default.
• W2025931567 cites W1982545384 @default.
• W2025931567 cites W1986025103 @default.
• W2025931567 cites W1986984578 @default.
• W2025931567 cites W1987206766 @default.
• W2025931567 cites W1987956458 @default.
• W2025931567 cites W1992802718 @default.
• W2025931567 cites W1993089591 @default.
• W2025931567 cites W1993844599 @default.
• W2025931567 cites W1995313730 @default.
• W2025931567 cites W1995465755 @default.
• W2025931567 cites W1995524697 @default.
• W2025931567 cites W1997296678 @default.
• W2025931567 cites W1999317982 @default.
• W2025931567 cites W2002173208 @default.
• W2025931567 cites W2007307339 @default.
• W2025931567 cites W2008027048 @default.
• W2025931567 cites W2010684112 @default.
• W2025931567 cites W2010788509 @default.
• W2025931567 cites W201230122 @default.
• W2025931567 cites W2015789902 @default.
• W2025931567 cites W2020713510 @default.
• W2025931567 cites W2022039597 @default.
• W2025931567 cites W2022140790 @default.
• W2025931567 cites W2023752372 @default.
• W2025931567 cites W2023853848 @default.
• W2025931567 cites W2024443320 @default.
• W2025931567 cites W2026975906 @default.
• W2025931567 cites W2029225004 @default.
• W2025931567 cites W2029373248 @default.
• W2025931567 cites W2029871872 @default.
• W2025931567 cites W2029914674 @default.
• W2025931567 cites W2030618826 @default.
• W2025931567 cites W2031315726 @default.
• W2025931567 cites W2031413037 @default.
• W2025931567 cites W2032351570 @default.
• W2025931567 cites W2032994747 @default.
• W2025931567 cites W2034852771 @default.
• W2025931567 cites W2035517952 @default.
• W2025931567 cites W2036112290 @default.
• W2025931567 cites W2036477971 @default.
• W2025931567 cites W2038017234 @default.
• W2025931567 cites W2038183520 @default.
• W2025931567 cites W2038251229 @default.
• W2025931567 cites W2038431038 @default.
• W2025931567 cites W2038652783 @default.
• W2025931567 cites W2039811101 @default.
• W2025931567 cites W2041572378 @default.
• W2025931567 cites W2042235085 @default.
• W2025931567 cites W2045591383 @default.
• W2025931567 cites W2045839188 @default.
• W2025931567 cites W2045941414 @default.
• W2025931567 cites W2046119469 @default.
• W2025931567 cites W2047140842 @default.
• W2025931567 cites W2047895561 @default.
• W2025931567 cites W2047993496 @default.
• W2025931567 cites W2049523175 @default.
• W2025931567 cites W2050608558 @default.
• W2025931567 cites W2051992908 @default.
• W2025931567 cites W2053573985 @default.
• W2025931567 cites W2054207437 @default.
• W2025931567 cites W2059853103 @default.
• W2025931567 cites W2060304697 @default.
• W2025931567 cites W2060494021 @default.

• next