FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025932021> ?p ?o ?g. }

• W2025932021 endingPage "1506" @default.
• W2025932021 startingPage "1496" @default.
• W2025932021 abstract "Fetal lower urinary tract obstruction (LUTO) is associated with high perinatal and long-term childhood mortality and morbidity. We aimed to assess the effectiveness of vesicoamniotic shunting for treatment of LUTO.In a randomised trial in the UK, Ireland, and the Netherlands, women whose pregnancies with a male fetus were complicated by isolated LUTO were randomly assigned by a central telephone and web-based randomisation service to receive either the intervention (placement of vesicoamniotic shunt) or conservative management. Allocation could not be masked from clinicians or participants because of the invasive nature of the intervention. Diagnosis was by prenatal ultrasound. The primary outcome was survival of the baby to 28 days postnatally. All primary analyses were done on an intention-to-treat basis, but these results were compared with those of an as-treated analysis to investigate the effect of a fairly large proportion of crossovers. We used Bayesian methods to estimate the posterior probability distribution of the effectiveness of vesicoamniotic shunting at 28 days. The study is registered with the ISRCTN Register, number ISRCTN53328556.31 women with singleton pregnancies complicated by LUTO were included in the trial and main analysis, with 16 allocated to the vesicoamniotic shunt group and 15 to the conservative management group. The study closed early because of poor recruitment. There were 12 livebirths in each group. In the vesicoamniotic shunt group one intrauterine death occurred and three pregnancies were terminated. In the conservative management group one intrauterine death occurred and two pregnancies were terminated. Of the 16 pregnancies randomly assigned to vesicoamniotic shunting, eight neonates survived to 28 days, compared with four from the 15 pregnancies assigned to conservative management (intention-to-treat relative risk [RR] 1·88, 95% CI 0·71-4·96; p=0·27). Analysis based on treatment received showed a larger effect (3·20, 1·06-9·62; p=0·03). All 12 deaths were caused by pulmonary hypoplasia in the early neonatal period. Sensitivity analysis in which non-treatment-related terminations of pregnancy were excluded made some slight changes to point estimates only. Bayesian analysis in which the trial data were combined with elicited priors from experts suggested an 86% probability that vesicoamniotic shunting increased survival at 28 days and a 25% probability that it had a large, clinically important effect (defined as a relative increase of 55% or more in the proportion of neonates who survived). There was substantial short-term and long-term morbidity in both groups, including poor renal function-only two babies (both in the shunt group) survived to 2 years with normal renal function. Seven complications occurred in six fetuses from the shunt group, including spontaneous ruptured membranes, shunt blockage, and dislodgement. These complications resulted in four pregnancy losses.Survival seemed to be higher in the fetuses receiving vesicoamniotic shunting, but the size and direction of the effect remained uncertain, such that benefit could not be conclusively proven. Our results suggest that the chance of newborn babies surviving with normal renal function is very low irrespective of whether or not vesicoamniotic shunting is done.UK National Institute of Health Research, Wellbeing of Women, Hannah Eliza Guy Charity (Birmingham Children's Hospital Charity)." @default.
• W2025932021 created "2016-06-24" @default.
• W2025932021 creator A5001381782 @default.
• W2025932021 creator A5009420648 @default.
• W2025932021 creator A5033482631 @default.
• W2025932021 creator A5034023807 @default.
• W2025932021 creator A5045595046 @default.
• W2025932021 creator A5065781703 @default.
• W2025932021 creator A5071482565 @default.
• W2025932021 creator A5074521357 @default.
• W2025932021 creator A5087241179 @default.
• W2025932021 creator A5088930027 @default.
• W2025932021 date "2013-11-01" @default.
• W2025932021 modified "2023-09-29" @default.
• W2025932021 title "Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial" @default.
• W2025932021 cites W1517555081 @default.
• W2025932021 cites W1525372304 @default.
• W2025932021 cites W1542399206 @default.
• W2025932021 cites W1550061059 @default.
• W2025932021 cites W1968748498 @default.
• W2025932021 cites W1976120195 @default.
• W2025932021 cites W1982722172 @default.
• W2025932021 cites W1985019597 @default.
• W2025932021 cites W1998061912 @default.
• W2025932021 cites W2017812506 @default.
• W2025932021 cites W2026258267 @default.
• W2025932021 cites W2034899264 @default.
• W2025932021 cites W2042792688 @default.
• W2025932021 cites W2053724154 @default.
• W2025932021 cites W2055525925 @default.
• W2025932021 cites W2059231588 @default.
• W2025932021 cites W2060062969 @default.
• W2025932021 cites W2076972856 @default.
• W2025932021 cites W2108077341 @default.
• W2025932021 cites W2167103927 @default.
• W2025932021 cites W2341405723 @default.
• W2025932021 cites W2402195651 @default.
• W2025932021 cites W4252540661 @default.
• W2025932021 cites W88170045 @default.
• W2025932021 doi "https://doi.org/10.1016/s0140-6736(13)60992-7" @default.
• W2025932021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3898962" @default.
• W2025932021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23953766" @default.
• W2025932021 hasPublicationYear "2013" @default.
• W2025932021 type Work @default.
• W2025932021 sameAs 2025932021 @default.
• W2025932021 citedByCount "277" @default.
• W2025932021 countsByYear W20259320212013 @default.
• W2025932021 countsByYear W20259320212014 @default.
• W2025932021 countsByYear W20259320212015 @default.
• W2025932021 countsByYear W20259320212016 @default.
• W2025932021 countsByYear W20259320212017 @default.
• W2025932021 countsByYear W20259320212018 @default.
• W2025932021 countsByYear W20259320212019 @default.
• W2025932021 countsByYear W20259320212020 @default.
• W2025932021 countsByYear W20259320212021 @default.
• W2025932021 countsByYear W20259320212022 @default.
• W2025932021 countsByYear W20259320212023 @default.
• W2025932021 crossrefType "journal-article" @default.
• W2025932021 hasAuthorship W2025932021A5001381782 @default.
• W2025932021 hasAuthorship W2025932021A5009420648 @default.
• W2025932021 hasAuthorship W2025932021A5033482631 @default.
• W2025932021 hasAuthorship W2025932021A5034023807 @default.
• W2025932021 hasAuthorship W2025932021A5045595046 @default.
• W2025932021 hasAuthorship W2025932021A5065781703 @default.
• W2025932021 hasAuthorship W2025932021A5071482565 @default.
• W2025932021 hasAuthorship W2025932021A5074521357 @default.
• W2025932021 hasAuthorship W2025932021A5087241179 @default.
• W2025932021 hasAuthorship W2025932021A5088930027 @default.
• W2025932021 hasBestOaLocation W20259320212 @default.
• W2025932021 hasConcept C126322002 @default.
• W2025932021 hasConcept C131872663 @default.
• W2025932021 hasConcept C141071460 @default.
• W2025932021 hasConcept C168563851 @default.
• W2025932021 hasConcept C172680121 @default.
• W2025932021 hasConcept C187212893 @default.
• W2025932021 hasConcept C2777135651 @default.
• W2025932021 hasConcept C2778248742 @default.
• W2025932021 hasConcept C2779234561 @default.
• W2025932021 hasConcept C2780813298 @default.
• W2025932021 hasConcept C2781056747 @default.
• W2025932021 hasConcept C44249647 @default.
• W2025932021 hasConcept C54355233 @default.
• W2025932021 hasConcept C71924100 @default.
• W2025932021 hasConcept C77411442 @default.
• W2025932021 hasConcept C82789193 @default.
• W2025932021 hasConcept C86803240 @default.
• W2025932021 hasConceptScore W2025932021C126322002 @default.
• W2025932021 hasConceptScore W2025932021C131872663 @default.
• W2025932021 hasConceptScore W2025932021C141071460 @default.
• W2025932021 hasConceptScore W2025932021C168563851 @default.
• W2025932021 hasConceptScore W2025932021C172680121 @default.
• W2025932021 hasConceptScore W2025932021C187212893 @default.
• W2025932021 hasConceptScore W2025932021C2777135651 @default.
• W2025932021 hasConceptScore W2025932021C2778248742 @default.
• W2025932021 hasConceptScore W2025932021C2779234561 @default.
• W2025932021 hasConceptScore W2025932021C2780813298 @default.
• W2025932021 hasConceptScore W2025932021C2781056747 @default.
• W2025932021 hasConceptScore W2025932021C44249647 @default.

• next