FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025933947> ?p ?o ?g. }

• W2025933947 endingPage "799" @default.
• W2025933947 startingPage "788" @default.
• W2025933947 abstract "Expression of insulin-like growth factor II in two human hepatocellular carcinoma cell lines and in hepatitis B, cirrhosis and hepatocellular carcinoma in 419 cases were investigated, and its relationship with the expression of hepatitis B virus x gene was studied by means of immunohistochemical and electron microscopic techniques. The results demonstrated that hepatocellular carcinoma cells (SMMC 7721 and QGY 7703) in culture could express insulin-like growth factor II. Expression seemed to be regulated by cell density, which was suggested as the molecular basis of the contact inhibition of cell proliferation. In tissue sections, cells with high expression of insulin-like growth factor II were observed not only in hepatocellular carcinoma (93%) but also in 95% of the pericancerous liver tissues, 72% of cirrhotic livers, 64% of chronic active hepatitis and 37% of chronic persistent hepatitis. in most cases of hepatocellular carcinoma, insulin-like growth factor II was localized in the cytoplasm of the cancer cells. in the benign liver disorders, four types of cells that highly expressed insulin-like growth factor II were observed: (a) a kind of small liver cell we named the small polygonal liver cell; (b) multinuclear giant hepatocytes; (c) hepatocytes in most of hyperplastic and neoplastic nodules, small hepatocyte nodules and some of regenerative nodules; and (d) some proliferating ductular cells. Even more interestingly, insulin-like growth factor II expression was shown to be closely related to the expression of hepatitis B virus x gene product. We suggest that the activation of insulin-like growth factor II gene and its overexpression may be a crucial step in the processes of hepatitis B virus—associated hepatocarcinogenesis and that the x gene product may activate the insulin-like growth factor II gene through a transactivation mechanism. in addition, we studied the characteristics of small polygonal liver cells, and the roles they may play in the regeneration and carcinogenesis of hepatitis B virus—infected liver are discussed. (Hepatology 1994;19:788–799)." @default.
• W2025933947 created "2016-06-24" @default.
• W2025933947 creator A5031030590 @default.
• W2025933947 creator A5036576811 @default.
• W2025933947 creator A5053099981 @default.
• W2025933947 creator A5055912373 @default.
• W2025933947 creator A5086468009 @default.
• W2025933947 creator A5087815948 @default.
• W2025933947 date "1994-10-01" @default.
• W2025933947 modified "2023-10-03" @default.
• W2025933947 title "Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: Its relationship with hepatitis B virus antigen expression" @default.
• W2025933947 cites W1437949713 @default.
• W2025933947 cites W1509427422 @default.
• W2025933947 cites W1557587989 @default.
• W2025933947 cites W1565623664 @default.
• W2025933947 cites W1593832483 @default.
• W2025933947 cites W1596979305 @default.
• W2025933947 cites W1656404511 @default.
• W2025933947 cites W1755067784 @default.
• W2025933947 cites W1865095437 @default.
• W2025933947 cites W1951553828 @default.
• W2025933947 cites W1964829819 @default.
• W2025933947 cites W1965996566 @default.
• W2025933947 cites W1971413146 @default.
• W2025933947 cites W1979102734 @default.
• W2025933947 cites W1985821855 @default.
• W2025933947 cites W1994281299 @default.
• W2025933947 cites W2000801534 @default.
• W2025933947 cites W2000989152 @default.
• W2025933947 cites W2003296270 @default.
• W2025933947 cites W2011607753 @default.
• W2025933947 cites W2024528924 @default.
• W2025933947 cites W2034473155 @default.
• W2025933947 cites W2035524411 @default.
• W2025933947 cites W2037468270 @default.
• W2025933947 cites W2038669400 @default.
• W2025933947 cites W2041604341 @default.
• W2025933947 cites W2049435717 @default.
• W2025933947 cites W2058093105 @default.
• W2025933947 cites W2063863464 @default.
• W2025933947 cites W2069581429 @default.
• W2025933947 cites W2072305097 @default.
• W2025933947 cites W2072373087 @default.
• W2025933947 cites W2077114688 @default.
• W2025933947 cites W2082015778 @default.
• W2025933947 cites W2082541645 @default.
• W2025933947 cites W2086519349 @default.
• W2025933947 cites W2096988448 @default.
• W2025933947 cites W2101333220 @default.
• W2025933947 cites W2103465949 @default.
• W2025933947 cites W2105382178 @default.
• W2025933947 cites W2114495500 @default.
• W2025933947 cites W2114575008 @default.
• W2025933947 cites W2125387792 @default.
• W2025933947 cites W2144266248 @default.
• W2025933947 cites W2161210575 @default.
• W2025933947 cites W2170076134 @default.
• W2025933947 cites W2204831117 @default.
• W2025933947 cites W2409094784 @default.
• W2025933947 cites W2417217118 @default.
• W2025933947 doi "https://doi.org/10.1002/hep.1840200404" @default.
• W2025933947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7927218" @default.
• W2025933947 hasPublicationYear "1994" @default.
• W2025933947 type Work @default.
• W2025933947 sameAs 2025933947 @default.
• W2025933947 citedByCount "95" @default.
• W2025933947 countsByYear W20259339472012 @default.
• W2025933947 countsByYear W20259339472013 @default.
• W2025933947 countsByYear W20259339472014 @default.
• W2025933947 countsByYear W20259339472015 @default.
• W2025933947 countsByYear W20259339472016 @default.
• W2025933947 countsByYear W20259339472017 @default.
• W2025933947 countsByYear W20259339472018 @default.
• W2025933947 countsByYear W20259339472022 @default.
• W2025933947 crossrefType "journal-article" @default.
• W2025933947 hasAuthorship W2025933947A5031030590 @default.
• W2025933947 hasAuthorship W2025933947A5036576811 @default.
• W2025933947 hasAuthorship W2025933947A5053099981 @default.
• W2025933947 hasAuthorship W2025933947A5055912373 @default.
• W2025933947 hasAuthorship W2025933947A5086468009 @default.
• W2025933947 hasAuthorship W2025933947A5087815948 @default.
• W2025933947 hasBestOaLocation W20259339471 @default.
• W2025933947 hasConcept C126322002 @default.
• W2025933947 hasConcept C159047783 @default.
• W2025933947 hasConcept C170493617 @default.
• W2025933947 hasConcept C202751555 @default.
• W2025933947 hasConcept C2522874641 @default.
• W2025933947 hasConcept C2775960820 @default.
• W2025933947 hasConcept C2776029263 @default.
• W2025933947 hasConcept C2776200302 @default.
• W2025933947 hasConcept C2776408679 @default.
• W2025933947 hasConcept C2776455275 @default.
• W2025933947 hasConcept C2777214474 @default.
• W2025933947 hasConcept C2778019345 @default.
• W2025933947 hasConcept C2779069268 @default.
• W2025933947 hasConcept C2780593183 @default.
• W2025933947 hasConcept C2992672570 @default.
• W2025933947 hasConcept C502942594 @default.

• next