FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025936105> ?p ?o ?g. }

• W2025936105 endingPage "2926" @default.
• W2025936105 startingPage "2920" @default.
• W2025936105 abstract "The organic cation transporter OCTN1 (SLC22A4) is expressed ubiquitously, with strong expression in kidney, trachea, bone marrow, and fetal liver, and it mediates transport of organic cations in a pH‐dependent manner. Recent studies have identified single nucleotide polymorphisms (SNPs) of OCTN1 in the Japanese population. Two SNPs present in the exon regions, c1063t and g1531a, cause amino acid mutation, Thr306Ile (T306I) and Gly462Glu (G462E), respectively. We examined the influence of these SNPs on the intracellular localization, protein expression, and transport activity of OCTN1. Immunocytochemical analysis showed similar localizations of OCTN1 in cellular membranes of HEK293 cells transiently transfected with an expression plasmid DNA for OCTN1 or its SNP allelic variants. The Km and Vmax values for tetraethylammonium (TEA) uptake by T306I were similar to those of the wild‐type even when the Vmax value was normalized for the expression level of OCTN1 protein. In contrast, G462E had almost negligible transport activity, although the protein expression level of G462E was equivalent to that of the wild‐type. We conclude that the SNP that causes the single amino acid mutation T306I does not affect TEA transport activity, whereas the mutation G462E abrogates the TEA transport activity, presumably affecting the physiological function of OCTN1 and/or the pharmacological characteristics of its substrates. © 2004 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:2920–2926, 2004" @default.
• W2025936105 created "2016-06-24" @default.
• W2025936105 creator A5017283437 @default.
• W2025936105 creator A5051094265 @default.
• W2025936105 creator A5052348746 @default.
• W2025936105 creator A5063611864 @default.
• W2025936105 date "2004-12-01" @default.
• W2025936105 modified "2023-10-16" @default.
• W2025936105 title "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population" @default.
• W2025936105 cites W1603436894 @default.
• W2025936105 cites W1859440284 @default.
• W2025936105 cites W1972946727 @default.
• W2025936105 cites W1974666828 @default.
• W2025936105 cites W1977244805 @default.
• W2025936105 cites W1986885996 @default.
• W2025936105 cites W2039568544 @default.
• W2025936105 cites W2072938074 @default.
• W2025936105 cites W2073136893 @default.
• W2025936105 cites W2087526401 @default.
• W2025936105 cites W2089558770 @default.
• W2025936105 cites W2096063169 @default.
• W2025936105 cites W2101403210 @default.
• W2025936105 cites W2103213593 @default.
• W2025936105 cites W2120722168 @default.
• W2025936105 cites W2160993714 @default.
• W2025936105 cites W2161310946 @default.
• W2025936105 cites W2614546484 @default.
• W2025936105 doi "https://doi.org/10.1002/jps.20190" @default.
• W2025936105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15459889" @default.
• W2025936105 hasPublicationYear "2004" @default.
• W2025936105 type Work @default.
• W2025936105 sameAs 2025936105 @default.
• W2025936105 citedByCount "26" @default.
• W2025936105 countsByYear W20259361052013 @default.
• W2025936105 countsByYear W20259361052014 @default.
• W2025936105 countsByYear W20259361052015 @default.
• W2025936105 countsByYear W20259361052016 @default.
• W2025936105 countsByYear W20259361052017 @default.
• W2025936105 countsByYear W20259361052018 @default.
• W2025936105 countsByYear W20259361052019 @default.
• W2025936105 countsByYear W20259361052020 @default.
• W2025936105 countsByYear W20259361052022 @default.
• W2025936105 crossrefType "journal-article" @default.
• W2025936105 hasAuthorship W2025936105A5017283437 @default.
• W2025936105 hasAuthorship W2025936105A5051094265 @default.
• W2025936105 hasAuthorship W2025936105A5052348746 @default.
• W2025936105 hasAuthorship W2025936105A5063611864 @default.
• W2025936105 hasConcept C104317684 @default.
• W2025936105 hasConcept C135763542 @default.
• W2025936105 hasConcept C143065580 @default.
• W2025936105 hasConcept C149011108 @default.
• W2025936105 hasConcept C153209595 @default.
• W2025936105 hasConcept C153911025 @default.
• W2025936105 hasConcept C168785527 @default.
• W2025936105 hasConcept C185592680 @default.
• W2025936105 hasConcept C189613389 @default.
• W2025936105 hasConcept C207583985 @default.
• W2025936105 hasConcept C2908647359 @default.
• W2025936105 hasConcept C501734568 @default.
• W2025936105 hasConcept C512185932 @default.
• W2025936105 hasConcept C515207424 @default.
• W2025936105 hasConcept C54355233 @default.
• W2025936105 hasConcept C55493867 @default.
• W2025936105 hasConcept C71924100 @default.
• W2025936105 hasConcept C86803240 @default.
• W2025936105 hasConcept C99454951 @default.
• W2025936105 hasConceptScore W2025936105C104317684 @default.
• W2025936105 hasConceptScore W2025936105C135763542 @default.
• W2025936105 hasConceptScore W2025936105C143065580 @default.
• W2025936105 hasConceptScore W2025936105C149011108 @default.
• W2025936105 hasConceptScore W2025936105C153209595 @default.
• W2025936105 hasConceptScore W2025936105C153911025 @default.
• W2025936105 hasConceptScore W2025936105C168785527 @default.
• W2025936105 hasConceptScore W2025936105C185592680 @default.
• W2025936105 hasConceptScore W2025936105C189613389 @default.
• W2025936105 hasConceptScore W2025936105C207583985 @default.
• W2025936105 hasConceptScore W2025936105C2908647359 @default.
• W2025936105 hasConceptScore W2025936105C501734568 @default.
• W2025936105 hasConceptScore W2025936105C512185932 @default.
• W2025936105 hasConceptScore W2025936105C515207424 @default.
• W2025936105 hasConceptScore W2025936105C54355233 @default.
• W2025936105 hasConceptScore W2025936105C55493867 @default.
• W2025936105 hasConceptScore W2025936105C71924100 @default.
• W2025936105 hasConceptScore W2025936105C86803240 @default.
• W2025936105 hasConceptScore W2025936105C99454951 @default.
• W2025936105 hasIssue "12" @default.
• W2025936105 hasLocation W20259361051 @default.
• W2025936105 hasLocation W20259361052 @default.
• W2025936105 hasOpenAccess W2025936105 @default.
• W2025936105 hasPrimaryLocation W20259361051 @default.
• W2025936105 hasRelatedWork W1550259003 @default.
• W2025936105 hasRelatedWork W1601442925 @default.
• W2025936105 hasRelatedWork W2134077256 @default.
• W2025936105 hasRelatedWork W2166471219 @default.
• W2025936105 hasRelatedWork W2171099227 @default.
• W2025936105 hasRelatedWork W2756225471 @default.
• W2025936105 hasRelatedWork W2975890143 @default.
• W2025936105 hasRelatedWork W2977263104 @default.

• next