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- W2025936415 abstract "The purpose of this study was to evaluate the sensorimotor skills of a spontaneous mouse mutant, Purkinje cell degeneration (PCD), marked by selective cerebellar cortical atrophy on a treadmill activated at 1 of 2 speeds and at 1 of 3 slopes, requiring forward movements to avoid footshocks. There was no difference in latencies before falling from the belt between PCD mutants and controls during acquisition. However, PCD mutants were impaired on the fast treadmill during retention, implicating the cerebellum in the memory of a motor skill. During acquisition of the slow treadmill task at the 2 lowest slopes of inclination, PCD mutants spent more time walking than controls, an indication of a decreased ability of coordinating whole body movements. The same pattern of higher walking time on the slow treadmill in PCD mutants was evident during retention. These results indicate that the cerebellar cortex is involved in the acquisition and the retention of a task requiring equilibrium." @default.
- W2025936415 created "2016-06-24" @default.
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- W2025936415 date "1998-01-01" @default.
- W2025936415 modified "2023-10-14" @default.
- W2025936415 title "Treadmill performance of mice with cerebellar lesions: 1. Purkinje cell degeneration mutant mice." @default.
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- W2025936415 doi "https://doi.org/10.1037//0735-7044.112.1.225" @default.
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