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• W2025942912 abstract "Background and purpose: In cardiac muscle, BRL 37344, a selective β3-adrenoceptor agonist, activates the Na+,K+-pump via NO signalling. This study investigated whether BRL 37344 also activates the Na+,K+-pump via β3-adrenoceptors in skeletal muscle. Experimental approach: Isolated rat soleus muscles were incubated between 1 and 60 min in buffer. Intracellular Na+,K+ content and Na+,K+-pump activity were measured using flame photometry and ouabain-suppressible 86Rb+ uptake, respectively. Additional muscles were mounted on force transducers and stimulated (60 Hz for 2 s) every 10 min. Key results: BRL 37344 (10-8-10-5 M) induced a concentration- and time-dependent reduction in intracellular Na+, and increased ouabain-suppressible 86Rb+ uptake by up to 112%. BRL 37344-induced reductions in intracellular Na+ were blocked by the β1/β2-adrenoceptor antagonist, nadolol (10-7 M), and the β2-adrenoceptor antagonist, ICI 118,551 (10-7-10-5 M), but not by β3- or β1-adrenoceptor antagonists, SR 59230A (10-7 M) and CGP 20712A (10-7-10-5 M), respectively. Another β3-adrenoceptor agonist, CL 316,243, did not alter intracellular Na+. BRL 37344-induced reductions in intracellular Na+ were not blocked by L-NAME, an NOS inhibitor, or ODQ, a guanylyl cyclase inhibitor. The NO donors, SNP and SNAP, did not alter intracellular Na+. BRL 37344 rapidly recovered force in muscles depressed by high [K+]o, an effect that was blocked by nadolol, but not L-NAME. Conclusions and implications: In rat soleus muscle, the β3-adrenoceptor agonist BRL 37344 stimulated the Na+,K+-pump via β2-adrenoceptors. A more selective β3-adrenoceptor agonist did not affect Na+, K+ homeostasis in skeletal muscle. NO did not seem to mediate Na+,K+-pump stimulation in skeletal muscle. British Journal of Pharmacology (2006) 149, 635–646. doi:10.1038/sj.bjp.0706896" @default.
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• W2025942912 date "2006-11-01" @default.
• W2025942912 modified "2023-09-27" @default.
• W2025942912 title "β3 -Adrenoceptor agonist stimulation of the Na+ ,K+ -pump in rat skeletal muscle is mediated by β2 - rather than β3 -adrenoceptors" @default.
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• W2025942912 doi "https://doi.org/10.1038/sj.bjp.0706896" @default.
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