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• W2025944561 abstract "In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid β peptide (Aβ) across the blood–brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion and neurovascular inflammation. Ultimately, this would lead to BBB compromise, to chemical imbalance in the neuronal environment and to synaptic and neuronal dysfunction, injury and loss. Based on the neurovascular hypothesis, I suggest an array of new potential therapeutic approaches that could be developed for AD, to enhance Aβ clearance and neurovascular repair, and to protect the neurovascular unit from divergent inducers of injury and apoptosis. In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid β peptide (Aβ) across the blood–brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion and neurovascular inflammation. Ultimately, this would lead to BBB compromise, to chemical imbalance in the neuronal environment and to synaptic and neuronal dysfunction, injury and loss. Based on the neurovascular hypothesis, I suggest an array of new potential therapeutic approaches that could be developed for AD, to enhance Aβ clearance and neurovascular repair, and to protect the neurovascular unit from divergent inducers of injury and apoptosis." @default.
• W2025944561 created "2016-06-24" @default.
• W2025944561 creator A5036566811 @default.
• W2025944561 date "2005-04-01" @default.
• W2025944561 modified "2023-10-18" @default.
• W2025944561 title "Neurovascular mechanisms of Alzheimer's neurodegeneration" @default.
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• W2025944561 doi "https://doi.org/10.1016/j.tins.2005.02.001" @default.
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• W2025944561 hasPublicationYear "2005" @default.
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