Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025951645> ?p ?o ?g. }
- W2025951645 endingPage "186" @default.
- W2025951645 startingPage "178" @default.
- W2025951645 abstract "In the present work, we studied the in vitro immunomodulatory properties of double-stranded Candida albicans DNA and its protective effect in murine disseminated candidiasis. DNA induced the production of TNF-alpha by peritoneal macrophages and splenocytes in vitro through a chloroquine-dependent mechanism. Yeast DNA acted synergistically with IFN-gamma in triggering the secretion of nitric oxide by macrophages and enabled them to stimulate the proliferation of T cells in response to soluble anti-CD3. The effect of DNA on splenocytes is associated with an enhanced synthesis of IFN-gamma, IL-2 and IL-10. In vivo, DNA decreased the mortality and lowered the kidney contamination in mice intraperitoneally inoculated with C. albicans simultaneously with an increase in the specific proliferative response and cytokine production. The present results indicate that C. albicans DNA can provide protection against disseminated infection." @default.
- W2025951645 created "2016-06-24" @default.
- W2025951645 creator A5005171261 @default.
- W2025951645 creator A5011370952 @default.
- W2025951645 creator A5086247761 @default.
- W2025951645 creator A5087697810 @default.
- W2025951645 date "2005-02-01" @default.
- W2025951645 modified "2023-10-09" @default.
- W2025951645 title "Candida albicans double-stranded DNA can participate in the host defense against disseminated candidiasis" @default.
- W2025951645 cites W1514540900 @default.
- W2025951645 cites W1519886765 @default.
- W2025951645 cites W1536488163 @default.
- W2025951645 cites W1578857830 @default.
- W2025951645 cites W1588809288 @default.
- W2025951645 cites W1589670817 @default.
- W2025951645 cites W1591928190 @default.
- W2025951645 cites W1597040835 @default.
- W2025951645 cites W1597998087 @default.
- W2025951645 cites W1731125787 @default.
- W2025951645 cites W1895687559 @default.
- W2025951645 cites W1971254079 @default.
- W2025951645 cites W1994688157 @default.
- W2025951645 cites W1995991884 @default.
- W2025951645 cites W1999587028 @default.
- W2025951645 cites W2007253594 @default.
- W2025951645 cites W2033441782 @default.
- W2025951645 cites W2045384882 @default.
- W2025951645 cites W2051881011 @default.
- W2025951645 cites W2053984506 @default.
- W2025951645 cites W2057055727 @default.
- W2025951645 cites W2057237586 @default.
- W2025951645 cites W2061549656 @default.
- W2025951645 cites W2064757084 @default.
- W2025951645 cites W2071482126 @default.
- W2025951645 cites W2076124962 @default.
- W2025951645 cites W2079735754 @default.
- W2025951645 cites W2085166735 @default.
- W2025951645 cites W2099361600 @default.
- W2025951645 cites W2117761826 @default.
- W2025951645 cites W2119110692 @default.
- W2025951645 cites W2131555965 @default.
- W2025951645 cites W2143839871 @default.
- W2025951645 cites W2145118219 @default.
- W2025951645 cites W2145564764 @default.
- W2025951645 cites W2149255798 @default.
- W2025951645 cites W2155345249 @default.
- W2025951645 cites W2155995906 @default.
- W2025951645 cites W2170819284 @default.
- W2025951645 cites W4244518364 @default.
- W2025951645 doi "https://doi.org/10.1016/j.micinf.2004.10.011" @default.
- W2025951645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15715977" @default.
- W2025951645 hasPublicationYear "2005" @default.
- W2025951645 type Work @default.
- W2025951645 sameAs 2025951645 @default.
- W2025951645 citedByCount "11" @default.
- W2025951645 countsByYear W20259516452012 @default.
- W2025951645 countsByYear W20259516452020 @default.
- W2025951645 crossrefType "journal-article" @default.
- W2025951645 hasAuthorship W2025951645A5005171261 @default.
- W2025951645 hasAuthorship W2025951645A5011370952 @default.
- W2025951645 hasAuthorship W2025951645A5086247761 @default.
- W2025951645 hasAuthorship W2025951645A5087697810 @default.
- W2025951645 hasConcept C134018914 @default.
- W2025951645 hasConcept C143425029 @default.
- W2025951645 hasConcept C145081991 @default.
- W2025951645 hasConcept C150903083 @default.
- W2025951645 hasConcept C189976730 @default.
- W2025951645 hasConcept C202751555 @default.
- W2025951645 hasConcept C203014093 @default.
- W2025951645 hasConcept C207001950 @default.
- W2025951645 hasConcept C2778690821 @default.
- W2025951645 hasConcept C2780917455 @default.
- W2025951645 hasConcept C519581460 @default.
- W2025951645 hasConcept C552990157 @default.
- W2025951645 hasConcept C55493867 @default.
- W2025951645 hasConcept C64241487 @default.
- W2025951645 hasConcept C86803240 @default.
- W2025951645 hasConcept C8891405 @default.
- W2025951645 hasConcept C89423630 @default.
- W2025951645 hasConceptScore W2025951645C134018914 @default.
- W2025951645 hasConceptScore W2025951645C143425029 @default.
- W2025951645 hasConceptScore W2025951645C145081991 @default.
- W2025951645 hasConceptScore W2025951645C150903083 @default.
- W2025951645 hasConceptScore W2025951645C189976730 @default.
- W2025951645 hasConceptScore W2025951645C202751555 @default.
- W2025951645 hasConceptScore W2025951645C203014093 @default.
- W2025951645 hasConceptScore W2025951645C207001950 @default.
- W2025951645 hasConceptScore W2025951645C2778690821 @default.
- W2025951645 hasConceptScore W2025951645C2780917455 @default.
- W2025951645 hasConceptScore W2025951645C519581460 @default.
- W2025951645 hasConceptScore W2025951645C552990157 @default.
- W2025951645 hasConceptScore W2025951645C55493867 @default.
- W2025951645 hasConceptScore W2025951645C64241487 @default.
- W2025951645 hasConceptScore W2025951645C86803240 @default.
- W2025951645 hasConceptScore W2025951645C8891405 @default.
- W2025951645 hasConceptScore W2025951645C89423630 @default.
- W2025951645 hasIssue "2" @default.
- W2025951645 hasLocation W20259516451 @default.