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• W2025954557 abstract "Pronounced changes including growth inhibition, increased matrix deposition and suppression of cell-associated proteolytic activity, take place in endothelial cells (EC) upon the application of TGF-β. Interrelationships between these effects have shed some light on the mechanism of action of TGF-β and on its role in regulating EC function vis-a-vis angiogenesis. For instance, preliminary evidence has indicated that increased levels of certain matrix components may be partly responsible for the antiproliferative action of TGF-β. In addition, TGF-β and bFGF have opposing effects on cellular proteolytic balance which may contribute to the antagonistic effect that TGF-β has on bFGF-induced EC growth and possibly to the anti-angiogenic effect exerted by TGF-β under certain circumstances. Of particular interest in this regard is the fact that physical contact between EC and vascular mural cells in EC:mural cell cocultures has been found to generate active TGF-β, thus further implicating TGF-β in the maintenance of the quiescent, differentiated aggreation of EC as found in vascular structures in vivo. While more information is needed to define what, if any, role TGF-β plays in endothelial differentiation, it is to be noted that many of the cellular and biochemical processes affected by TGF-β are linked to differentiation. It is therefore possible that the growth inhibition of EC by TGF-β primes them for differentiation and/or is critical for the maintenance of a differentiated state." @default.
• W2025954557 created "2016-06-24" @default.
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• W2025954557 date "1991-11-01" @default.
• W2025954557 modified "2023-10-14" @default.
• W2025954557 title "Endothelial cell regulation by transforming growth factor-beta" @default.
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• W2025954557 doi "https://doi.org/10.1002/jcb.240470307" @default.
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