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- W2025956906 abstract "ObjectivesAttention deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neurobehavioral disorder of childhood, yet its etiology is not well understood. In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired in ADHD.Data sourcesHuman and animal studies of developmental PCB or lead exposures that assessed specific functional domains shown to be impaired in ADHD children were identified via searches of PubMed using “lead” or “PCB exposure” in combination with key words, including “attention,” “working memory,” “response inhibition,” “executive function,” “cognitive function,” “behavior,” and “ADHD.”Data synthesisChildren and laboratory animals exposed to lead or PCBs show deficits in many aspects of attention and executive function that have been shown to be impaired in children diagnosed with ADHD, including tests of working memory, response inhibition, vigilance, and alertness. Studies conducted to date suggest that lead may reduce both attention and response inhibition, whereas PCBs may impair response inhibition to a greater degree than attention. Low-level lead exposure has been associated with a clinical diagnosis of ADHD in several recent studies. Similar studies of PCBs have not been conducted.ConclusionsWe speculate that exposures to environmental contaminants, including lead and PCBs, may increase the prevalence of ADHD." @default.
- W2025956906 created "2016-06-24" @default.
- W2025956906 creator A5021955209 @default.
- W2025956906 creator A5024952055 @default.
- W2025956906 creator A5050658426 @default.
- W2025956906 date "2010-12-01" @default.
- W2025956906 modified "2023-10-15" @default.
- W2025956906 title "Lead and PCBs as Risk Factors for Attention Deficit/Hyperactivity Disorder" @default.
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