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• W2025958196 startingPage "11465" @default.
• W2025958196 abstract "In search of proteins which interact with activated steroid hormone receptors, we screened a human liver lambda gt11 expression library with the glucocorticoid receptor. We identified and cloned a cDNA sequence of 1322 bp that encodes a protein of 274 aa. This protein consists predominantly of hydrophilic amino acids and contains a putative bipartite nuclear localization signal. The in vitro translated receptor-associating protein runs in SDS/polyacrylamide gels with an apparent molecular mass of 46 kDa. By use of the bacterially expressed fusion protein with glutathione S-transferase we have found that interaction is not limited to the glucocorticoid receptor but included other nuclear receptors--most notably, the estrogen and thyroid receptors. Binding also occurs with the glucocorticoid receptor complexed with the antiglucocorticoid RU 38486, with the estrogen receptor complexed with the antiestrogen 4-hydroxytamoxifen or ICI 164,384, and even with receptors not complexed with ligand. Association with steroid hormone receptors depends on prior receptor activation--i.e., release from heat shock proteins. The sequence identified here appears to be a general partner protein for nuclear hormone receptors, with the gene being expressed in a variety of mammalian tissues." @default.
• W2025958196 created "2016-06-24" @default.
• W2025958196 creator A5022413250 @default.
• W2025958196 creator A5037992171 @default.
• W2025958196 date "1995-12-05" @default.
• W2025958196 modified "2023-09-27" @default.
• W2025958196 title "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning." @default.
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• W2025958196 doi "https://doi.org/10.1073/pnas.92.25.11465" @default.
• W2025958196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/40422" @default.
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