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- W2025959519 abstract "Abstract The replication of the 2 μm DNA of Saccharomyces cerevisiae has been examined in cell division cycle ( cdc ) mutants. The 2 μm DNA does not replicate at the restrictive temperature in cells bearing the cdc 28, cdc 4, and cdc 7 mutations which prevent passage of cells from the G1 phase into S phase. Plasmid replication also is prevented in a mating-type cells by α factor, a mating hormone which prevents cells from completing an event early in G1 phase. The 2 μm DNA ceases replication at 36 °C in a mutant harboring the cdc 8 mutation, a defect in the elongation reactions of nuclear DNA replication. Plasmid replication continues at the restrictive temperature for approximately one generation in a cdc 13 mutant defective in nuclear division. These results show that 2 μm DNA replication is controlled by the same genes that control the initiation and completion of nuclear DNA replication." @default.
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- W2025959519 date "1977-10-01" @default.
- W2025959519 modified "2023-09-23" @default.
- W2025959519 title "Control of Saccharomyces cerevisiae 2μm DNA replication by cell division cycle genes that control nuclear DNA replication" @default.
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- W2025959519 doi "https://doi.org/10.1016/0022-2836(77)90215-7" @default.
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