Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025961918> ?p ?o ?g. }
- W2025961918 endingPage "132" @default.
- W2025961918 startingPage "126" @default.
- W2025961918 abstract "Thymus and activation-regulated chemokine (TARC/CCL17) is a Th2-type chemokine and its receptor CC chemokine receptor 4 (CCR4) is preferentially expressed on Th2 cells. Langerhans cells (LC) are immature dendritic cells (DC) in the epidermis of the skin and play vital roles in immune response. In this study, we investigated TARC expression by murine freshly isolated LC and 48 h cultured (mature) LC, and the regulation of TARC production in cultured LC by various cytokines. Murine LC was prepared using a panning method from BALB/c mice. RT-PCR was performed using fresh and cultured LC to evaluate TARC mRNA levels. ELISA was carried out using supernatant of cultured LC to calculate secreted TARC protein levels. TARC mRNA was strongly upregulated during maturation of murine LC. TARC production by murine LC was upregulated by TNF-α and IL-4 and downregulated by IFN-γ, dose-dependently. Th1 and Th2 cytokines reciprocally regulate the production of Th2-type chemokine TARC by murine LC. Th2 cytokine microenvironments in skin may increase TARC production by mature LC, providing attraction of Th2 cells in skin. This may be an amplification circuit in Th2-dominant inflammatory skin disease like atopic dermatitis." @default.
- W2025961918 created "2016-06-24" @default.
- W2025961918 creator A5006213079 @default.
- W2025961918 creator A5015950702 @default.
- W2025961918 creator A5018150140 @default.
- W2025961918 creator A5024531277 @default.
- W2025961918 creator A5030954224 @default.
- W2025961918 creator A5042270087 @default.
- W2025961918 creator A5063280552 @default.
- W2025961918 creator A5067689004 @default.
- W2025961918 creator A5081771204 @default.
- W2025961918 creator A5083485606 @default.
- W2025961918 creator A5087518933 @default.
- W2025961918 date "2003-08-01" @default.
- W2025961918 modified "2023-10-16" @default.
- W2025961918 title "Thymus and activation-regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-α and IL-4 and downregulated by IFN-γ" @default.
- W2025961918 cites W1583446759 @default.
- W2025961918 cites W1661544713 @default.
- W2025961918 cites W1966959415 @default.
- W2025961918 cites W1967695968 @default.
- W2025961918 cites W1972725501 @default.
- W2025961918 cites W1976905332 @default.
- W2025961918 cites W1991195369 @default.
- W2025961918 cites W2014125703 @default.
- W2025961918 cites W2017740184 @default.
- W2025961918 cites W2019167069 @default.
- W2025961918 cites W2038610464 @default.
- W2025961918 cites W2046842929 @default.
- W2025961918 cites W2047018108 @default.
- W2025961918 cites W2058266118 @default.
- W2025961918 cites W2079136206 @default.
- W2025961918 cites W2082086413 @default.
- W2025961918 cites W2103384599 @default.
- W2025961918 cites W2104979790 @default.
- W2025961918 cites W2111220263 @default.
- W2025961918 cites W2117342688 @default.
- W2025961918 cites W2118526748 @default.
- W2025961918 cites W2118954607 @default.
- W2025961918 cites W2123260343 @default.
- W2025961918 cites W2136267701 @default.
- W2025961918 cites W2144303960 @default.
- W2025961918 cites W2149116434 @default.
- W2025961918 cites W2154376533 @default.
- W2025961918 cites W2157069655 @default.
- W2025961918 cites W2161167143 @default.
- W2025961918 cites W2163840855 @default.
- W2025961918 cites W2184454519 @default.
- W2025961918 cites W97158386 @default.
- W2025961918 doi "https://doi.org/10.1016/s1043-4666(03)00221-7" @default.
- W2025961918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12967648" @default.
- W2025961918 hasPublicationYear "2003" @default.
- W2025961918 type Work @default.
- W2025961918 sameAs 2025961918 @default.
- W2025961918 citedByCount "54" @default.
- W2025961918 countsByYear W20259619182012 @default.
- W2025961918 countsByYear W20259619182013 @default.
- W2025961918 countsByYear W20259619182014 @default.
- W2025961918 countsByYear W20259619182015 @default.
- W2025961918 countsByYear W20259619182016 @default.
- W2025961918 countsByYear W20259619182017 @default.
- W2025961918 countsByYear W20259619182018 @default.
- W2025961918 countsByYear W20259619182019 @default.
- W2025961918 countsByYear W20259619182020 @default.
- W2025961918 countsByYear W20259619182021 @default.
- W2025961918 countsByYear W20259619182022 @default.
- W2025961918 countsByYear W20259619182023 @default.
- W2025961918 crossrefType "journal-article" @default.
- W2025961918 hasAuthorship W2025961918A5006213079 @default.
- W2025961918 hasAuthorship W2025961918A5015950702 @default.
- W2025961918 hasAuthorship W2025961918A5018150140 @default.
- W2025961918 hasAuthorship W2025961918A5024531277 @default.
- W2025961918 hasAuthorship W2025961918A5030954224 @default.
- W2025961918 hasAuthorship W2025961918A5042270087 @default.
- W2025961918 hasAuthorship W2025961918A5063280552 @default.
- W2025961918 hasAuthorship W2025961918A5067689004 @default.
- W2025961918 hasAuthorship W2025961918A5081771204 @default.
- W2025961918 hasAuthorship W2025961918A5083485606 @default.
- W2025961918 hasAuthorship W2025961918A5087518933 @default.
- W2025961918 hasConcept C104317684 @default.
- W2025961918 hasConcept C127561419 @default.
- W2025961918 hasConcept C12823836 @default.
- W2025961918 hasConcept C128879288 @default.
- W2025961918 hasConcept C13373296 @default.
- W2025961918 hasConcept C143172330 @default.
- W2025961918 hasConcept C153911025 @default.
- W2025961918 hasConcept C185592680 @default.
- W2025961918 hasConcept C203014093 @default.
- W2025961918 hasConcept C2775866117 @default.
- W2025961918 hasConcept C55493867 @default.
- W2025961918 hasConcept C86803240 @default.
- W2025961918 hasConcept C8891405 @default.
- W2025961918 hasConcept C95444343 @default.
- W2025961918 hasConceptScore W2025961918C104317684 @default.
- W2025961918 hasConceptScore W2025961918C127561419 @default.
- W2025961918 hasConceptScore W2025961918C12823836 @default.
- W2025961918 hasConceptScore W2025961918C128879288 @default.
- W2025961918 hasConceptScore W2025961918C13373296 @default.
- W2025961918 hasConceptScore W2025961918C143172330 @default.