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- W2025976912 abstract "We have recently described a potential antineoplastic effect of prostaglandin D2 (PGD2) (Fukushima, M., Kato, T., Ueda, R., Ota, K., Narumiya, S., and Hayaishi, O. (1982) Biochem. Biophys. Res. Commun. 105, 956–964). In the present study three analogues of PGD2 were examined for their antineoplastic and other biological activities. 9-Deoxy-Δ9-PGD2, a dehydrate of PGD2, had about 3 times stronger growth inhibitory effect than PGD2 on L1210 leukemia cultured cells. The IC50 value of this compound was 0.5–1.0 μg/ml (2μM). In contrast to PGD2, this compound lacked a contracting activity on colonic smooth muscle and caused less diarrhea. The antiaggregatory action of the compound on blood platelet was about 10 times weaker than PGD2. The growth inhibitory activity was also observed with cyclopentenone itself; the IC50 value was about 100 μM. On the other hand, BW245C which had the antiaggregatory activity comparable with PGD2 showed no growth inhibition. These results suggest that cyclopentenone structure is an essential moiety of prostaglandin derivaties for cell growth inhibition and that the growth inhibitory activity could be dissociated from other biological activities of prostaglandins." @default.
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- W2025976912 date "1982-12-01" @default.
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- W2025976912 title "9-Deoxy-Δ9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities" @default.
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- W2025976912 doi "https://doi.org/10.1016/0006-291x(82)91986-6" @default.
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