Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025978032> ?p ?o ?g. }
- W2025978032 endingPage "142" @default.
- W2025978032 startingPage "133" @default.
- W2025978032 abstract "Catalase was continuously inhibited with aminotriazole in the liver and kidney during 33 months in large populations of old and young frogs in order to study the effects of the modification of the tissue antioxidant/prooxidant balance on the life span of a vertebrate species showing an oxygen consumption rate similar to that of humans. Free-radical-related parameters were measured during three consecutive years at 2.5, 14.5, and 26.5 months of experimentation. Aging per se did not decrease antioxidant enzymes and did not increase peroxidation (thiobarbituric acid positive substances, or high-pressure liquid chromatography [HPLC]-malondialdehyde), either cross sectionally or longitudinally. Long-term catalase inhibition leads to time-dependent increases (100–900%) of endogenous superoxide dismutase, GSH, ascorbate, and especially glutathione reductase at 2.5 and 14.5 months of experimentation. This was positively correlated with a higher survival of treated animals (91% in treated versus 46% in controls at 14.5 months of experimentation). The loss of those inductions after 26.5 months leads to a sharp increase in mortality rate. The results show for the first time that simultaneous induction of various tissue antioxidant enzymes and nonenzymatic antioxidants can increase the mean life span of a vertebrate animal. It is concluded that the tissue antioxidant/prooxidant balance is a strong determinant of mean life span." @default.
- W2025978032 created "2016-06-24" @default.
- W2025978032 creator A5012871087 @default.
- W2025978032 creator A5030906936 @default.
- W2025978032 creator A5046103356 @default.
- W2025978032 creator A5055681712 @default.
- W2025978032 creator A5082005857 @default.
- W2025978032 date "1993-08-01" @default.
- W2025978032 modified "2023-10-18" @default.
- W2025978032 title "Simultaneous induction of SOD, glutathione reductase, GSH, and ascorbate in liver and kidney correlates with survival during aging" @default.
- W2025978032 cites W1561096292 @default.
- W2025978032 cites W1622572912 @default.
- W2025978032 cites W1768247331 @default.
- W2025978032 cites W1775749144 @default.
- W2025978032 cites W1794621064 @default.
- W2025978032 cites W186344272 @default.
- W2025978032 cites W1971443296 @default.
- W2025978032 cites W1975980695 @default.
- W2025978032 cites W1980500760 @default.
- W2025978032 cites W1989733101 @default.
- W2025978032 cites W2004039119 @default.
- W2025978032 cites W2007064404 @default.
- W2025978032 cites W2009426634 @default.
- W2025978032 cites W2015832708 @default.
- W2025978032 cites W2017231344 @default.
- W2025978032 cites W2018823412 @default.
- W2025978032 cites W2025086598 @default.
- W2025978032 cites W2027083704 @default.
- W2025978032 cites W2044202976 @default.
- W2025978032 cites W2044396346 @default.
- W2025978032 cites W2048267064 @default.
- W2025978032 cites W2055362731 @default.
- W2025978032 cites W2064000861 @default.
- W2025978032 cites W2075417836 @default.
- W2025978032 cites W2089110340 @default.
- W2025978032 cites W2118519973 @default.
- W2025978032 cites W2252625178 @default.
- W2025978032 cites W2315512556 @default.
- W2025978032 cites W313215553 @default.
- W2025978032 cites W54013240 @default.
- W2025978032 cites W8750466 @default.
- W2025978032 doi "https://doi.org/10.1016/0891-5849(93)90052-v" @default.
- W2025978032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8375690" @default.
- W2025978032 hasPublicationYear "1993" @default.
- W2025978032 type Work @default.
- W2025978032 sameAs 2025978032 @default.
- W2025978032 citedByCount "81" @default.
- W2025978032 countsByYear W20259780322012 @default.
- W2025978032 countsByYear W20259780322013 @default.
- W2025978032 countsByYear W20259780322014 @default.
- W2025978032 countsByYear W20259780322015 @default.
- W2025978032 countsByYear W20259780322017 @default.
- W2025978032 countsByYear W20259780322021 @default.
- W2025978032 countsByYear W20259780322023 @default.
- W2025978032 crossrefType "journal-article" @default.
- W2025978032 hasAuthorship W2025978032A5012871087 @default.
- W2025978032 hasAuthorship W2025978032A5030906936 @default.
- W2025978032 hasAuthorship W2025978032A5046103356 @default.
- W2025978032 hasAuthorship W2025978032A5055681712 @default.
- W2025978032 hasAuthorship W2025978032A5082005857 @default.
- W2025978032 hasConcept C126322002 @default.
- W2025978032 hasConcept C134018914 @default.
- W2025978032 hasConcept C165069038 @default.
- W2025978032 hasConcept C181199279 @default.
- W2025978032 hasConcept C185592680 @default.
- W2025978032 hasConcept C2775838275 @default.
- W2025978032 hasConcept C2777504301 @default.
- W2025978032 hasConcept C2778004101 @default.
- W2025978032 hasConcept C2778401633 @default.
- W2025978032 hasConcept C2778760513 @default.
- W2025978032 hasConcept C2778979269 @default.
- W2025978032 hasConcept C2780091579 @default.
- W2025978032 hasConcept C2780829032 @default.
- W2025978032 hasConcept C538909803 @default.
- W2025978032 hasConcept C55493867 @default.
- W2025978032 hasConcept C71924100 @default.
- W2025978032 hasConcept C86803240 @default.
- W2025978032 hasConceptScore W2025978032C126322002 @default.
- W2025978032 hasConceptScore W2025978032C134018914 @default.
- W2025978032 hasConceptScore W2025978032C165069038 @default.
- W2025978032 hasConceptScore W2025978032C181199279 @default.
- W2025978032 hasConceptScore W2025978032C185592680 @default.
- W2025978032 hasConceptScore W2025978032C2775838275 @default.
- W2025978032 hasConceptScore W2025978032C2777504301 @default.
- W2025978032 hasConceptScore W2025978032C2778004101 @default.
- W2025978032 hasConceptScore W2025978032C2778401633 @default.
- W2025978032 hasConceptScore W2025978032C2778760513 @default.
- W2025978032 hasConceptScore W2025978032C2778979269 @default.
- W2025978032 hasConceptScore W2025978032C2780091579 @default.
- W2025978032 hasConceptScore W2025978032C2780829032 @default.
- W2025978032 hasConceptScore W2025978032C538909803 @default.
- W2025978032 hasConceptScore W2025978032C55493867 @default.
- W2025978032 hasConceptScore W2025978032C71924100 @default.
- W2025978032 hasConceptScore W2025978032C86803240 @default.
- W2025978032 hasIssue "2" @default.
- W2025978032 hasLocation W20259780321 @default.
- W2025978032 hasLocation W20259780322 @default.
- W2025978032 hasOpenAccess W2025978032 @default.