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• W2025979901 abstract "In the present experiment, 6-OHDA was infused directly into the olfactory bulb (OB) to produce a localized neurotoxic lesion. Habituation/ dishabituation behavioral tests were then conducted to measure recognition responses to chemical cues (urine as a stimulus) and to social stimuli (ovariectomized rat as a stimulus). Infusion of 6-OHDA resulted in a near complete depletion of OB-norepinephrine (NE), whereas it had little effect (15% reduction) on OB dopamine (DA) contents. Nor were any significant effects on hypothalamic, hippocampal, olfactory tubercle, and corpus striatal NE and DA contents observed. Behaviorally, dishabituation responses to chemical cues were greatly impaired, however there was relatively little effect on social behavior dishabituation responses. Theses results demonstrate that 6-OHDA can be used to produce a near complete but localized depletion of OB-NE. This treatment impairs dishabituation responses to chemical cues but not social stimuli indicating that OB-NE appears necessary for processing of chemical cue, but not social memory recognition process." @default.
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• W2025979901 date "1993-09-01" @default.
• W2025979901 modified "2023-10-03" @default.
• W2025979901 title "Depletion of olfactory bulb norepinephrine by 6-OHDA disrupts chemical cue but not social recognition responses in male rats" @default.
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• W2025979901 doi "https://doi.org/10.1016/0006-8993(93)90800-3" @default.
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