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- W2025979968 abstract "Abstract Rationale Recent guidelines suggest that intranasal corticosteroids should be used as first-line treatment for controlling persistent symptoms of allergic rhinitis (AR), but long-term continual use of corticosteroids can raise growth concerns in a pediatric population. Effects of the recommended once-daily dose of budesonide aqueous nasal spray (BANS; Rhinocort Aqua ® ) on growth velocity were examined in pediatric patients with perennial AR. Methods In this 1-year, multicenter, double-blind, placebo-controlled study, 229 pediatric patients (aged 4 to 8 years) with perennial AR were treated with once-daily BANS (64 μg) or placebo. Change in growth velocity and in the percentage of patients whose percentile for height decreased from the 6-month baseline to end of treatment were examined using stadiometry. Results Mean growth velocity (± SE) during the treatment period was 5.91 ± 0.11 cm/year for the BANS group and 6.19 ± 0.16 cm/year for the placebo group. The difference in growth velocity between groups was not significantly different during the 1-year treatment period (0.27 ± 0.18 cm/year; 95% CI, −0.07 to 0.62). The percentage of patients whose percentile for height decreased during the study was also not significantly different between groups (58.5% BANS, 54.1% placebo; p=.64). The incidence and types of adverse events were similar between treatment groups. Five placebo patients and zero BANS patients reported serious adverse events during the treatment period. Conclusion Administration of budesonide aqueous nasal spray 64 μg once daily for 1 year does not suppress growth velocity and is well tolerated in pediatric patients aged 4 to 8 years with perennial AR." @default.
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- W2025979968 date "2004-02-01" @default.
- W2025979968 modified "2023-09-27" @default.
- W2025979968 title "Recommended once-daily dose of budesonide aqueous nasal spray (Rhinocort AquaS) does not suppress growth velocity in pediatric patients with perennial allergic rhinitis*1" @default.
- W2025979968 doi "https://doi.org/10.1016/j.jaci.2004.01.065" @default.
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