Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025994996> ?p ?o ?g. }
- W2025994996 endingPage "51" @default.
- W2025994996 startingPage "41" @default.
- W2025994996 abstract "Gelsolin, an 82 kDa actin-binding protein, has potent actin filament-severing activity in vitro. To investigate the in vivo function of gelsolin, transgenic gelsolin-null (Gsn-) mice were generated and found to have normal embryonic development and longevity. However, platelet shape changes are decreased in Gsn- mice, causing prolonged bleeding times. Neutrophil migration in vivo into peritoneal exudates and in vitro is delayed. Gsn- dermal fibroblasts have excessive actin stress fibers and migrate more slowly than wild-type fibroblasts, but have increased contractility in vitro. These observations establish the requirement of gelsolin for rapid motile responses in cell types involved in stress responses such as hemostasis, inflammation, and wound healing. Neither gelsolin nor other proteins with similar actin filament-severing activity are expressed in early embryonic cells, indicating that this mechanism of actin filament dynamics is not essential for motility during early embryogenesis." @default.
- W2025994996 created "2016-06-24" @default.
- W2025994996 creator A5010278316 @default.
- W2025994996 creator A5033196024 @default.
- W2025994996 creator A5044052948 @default.
- W2025994996 creator A5069017504 @default.
- W2025994996 creator A5071191923 @default.
- W2025994996 creator A5089963272 @default.
- W2025994996 date "1995-04-01" @default.
- W2025994996 modified "2023-10-07" @default.
- W2025994996 title "Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin" @default.
- W2025994996 cites W100697261 @default.
- W2025994996 cites W129345003 @default.
- W2025994996 cites W1513007967 @default.
- W2025994996 cites W1520440482 @default.
- W2025994996 cites W1535191554 @default.
- W2025994996 cites W1541586041 @default.
- W2025994996 cites W1544976636 @default.
- W2025994996 cites W1583987899 @default.
- W2025994996 cites W1607116311 @default.
- W2025994996 cites W1662223019 @default.
- W2025994996 cites W1662771652 @default.
- W2025994996 cites W1970092562 @default.
- W2025994996 cites W1972617251 @default.
- W2025994996 cites W1977621167 @default.
- W2025994996 cites W1982641617 @default.
- W2025994996 cites W1984357171 @default.
- W2025994996 cites W1984732269 @default.
- W2025994996 cites W1988312243 @default.
- W2025994996 cites W1993834457 @default.
- W2025994996 cites W1999350913 @default.
- W2025994996 cites W2000186902 @default.
- W2025994996 cites W2001789247 @default.
- W2025994996 cites W2002857997 @default.
- W2025994996 cites W2007660746 @default.
- W2025994996 cites W2009358465 @default.
- W2025994996 cites W2015630654 @default.
- W2025994996 cites W2020323660 @default.
- W2025994996 cites W2023151777 @default.
- W2025994996 cites W2024524102 @default.
- W2025994996 cites W2025404281 @default.
- W2025994996 cites W2028901976 @default.
- W2025994996 cites W2029872541 @default.
- W2025994996 cites W2030463167 @default.
- W2025994996 cites W2039978832 @default.
- W2025994996 cites W2044652083 @default.
- W2025994996 cites W2046241907 @default.
- W2025994996 cites W2058009854 @default.
- W2025994996 cites W2066602623 @default.
- W2025994996 cites W2069521331 @default.
- W2025994996 cites W2072735811 @default.
- W2025994996 cites W2090712867 @default.
- W2025994996 cites W2091400786 @default.
- W2025994996 cites W2093226717 @default.
- W2025994996 cites W2105416994 @default.
- W2025994996 cites W2110110734 @default.
- W2025994996 cites W2116426240 @default.
- W2025994996 cites W2122005485 @default.
- W2025994996 cites W2125510211 @default.
- W2025994996 cites W2137583122 @default.
- W2025994996 cites W2137736246 @default.
- W2025994996 cites W2148146060 @default.
- W2025994996 cites W2169406360 @default.
- W2025994996 cites W2171535341 @default.
- W2025994996 cites W2412897129 @default.
- W2025994996 cites W4229808351 @default.
- W2025994996 doi "https://doi.org/10.1016/0092-8674(95)90369-0" @default.
- W2025994996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7720072" @default.
- W2025994996 hasPublicationYear "1995" @default.
- W2025994996 type Work @default.
- W2025994996 sameAs 2025994996 @default.
- W2025994996 citedByCount "417" @default.
- W2025994996 countsByYear W20259949962012 @default.
- W2025994996 countsByYear W20259949962013 @default.
- W2025994996 countsByYear W20259949962014 @default.
- W2025994996 countsByYear W20259949962015 @default.
- W2025994996 countsByYear W20259949962016 @default.
- W2025994996 countsByYear W20259949962017 @default.
- W2025994996 countsByYear W20259949962018 @default.
- W2025994996 countsByYear W20259949962019 @default.
- W2025994996 countsByYear W20259949962020 @default.
- W2025994996 countsByYear W20259949962021 @default.
- W2025994996 countsByYear W20259949962022 @default.
- W2025994996 countsByYear W20259949962023 @default.
- W2025994996 crossrefType "journal-article" @default.
- W2025994996 hasAuthorship W2025994996A5010278316 @default.
- W2025994996 hasAuthorship W2025994996A5033196024 @default.
- W2025994996 hasAuthorship W2025994996A5044052948 @default.
- W2025994996 hasAuthorship W2025994996A5069017504 @default.
- W2025994996 hasAuthorship W2025994996A5071191923 @default.
- W2025994996 hasAuthorship W2025994996A5089963272 @default.
- W2025994996 hasBestOaLocation W20259949961 @default.
- W2025994996 hasConcept C125705527 @default.
- W2025994996 hasConcept C150903083 @default.
- W2025994996 hasConcept C202751555 @default.
- W2025994996 hasConcept C207001950 @default.
- W2025994996 hasConcept C55493867 @default.
- W2025994996 hasConcept C80722340 @default.