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• W2025997629 endingPage "1733" @default.
• W2025997629 startingPage "1725" @default.
• W2025997629 abstract "Endothelial cell (EC) migration has been studied on aminophase surfaces with covalently bound RGDS and YIGSRG cell adhesion peptides. The fluorescent marker dansyl chloride was used to quantify the spatial distribution of the peptides on the modified surfaces. Peptides appeared to be distributed in uniformly dispersed large clusters separated by areas of lower peptide concentrations. We employed digital time-lapse video microscopy and image analysis to monitor EC migration on the modified surfaces and to reconstruct the cell trajectories. The persistent random walk model was then applied to analyze the cell displacement data and compute the mean root square speed, the persistence time, and the random motility coefficient of EC. We also calculated the time-averaged speed of cell locomotion. No differences in the speed of cell locomotion on the various substrates were noted. Immobilization of the cell adhesion peptides (RGDS and YIGSRG), however, significantly increased the persistence of cell movement and, thus, the random motility coefficient. These results suggest that immobilization of cell adhesion peptides on the surface of implantable biomaterials may lead to enhanced endothelization rates." @default.
• W2025997629 created "2016-06-24" @default.
• W2025997629 creator A5063948670 @default.
• W2025997629 date "2000-09-01" @default.
• W2025997629 modified "2023-09-27" @default.
• W2025997629 title "Endothelial cell migration on surfaces modified with immobilized adhesive peptides" @default.
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• W2025997629 doi "https://doi.org/10.1016/s0142-9612(99)00205-7" @default.
• W2025997629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10905454" @default.
• W2025997629 hasPublicationYear "2000" @default.
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