FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026007973> ?p ?o ?g. }

• W2026007973 endingPage "492" @default.
• W2026007973 startingPage "483" @default.
• W2026007973 abstract "Purpose: To examine the ability of a heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, to modify thermal response and heat‐induced cell killing, and to clarify the underlining mechanisms.Materials and methods: A human oesophageal cancer cell line (TE‐1), with a mutant p53 gene, was used. To examine the effect of radicicol on heat‐induced cell killing, radicicol at a concentration of 100 nM was incubated with the cells for 7 h during heat treatment. Changes in the expression of proteins were examined by Western blot and immunofluorescence analysis.Results: Radicicol in combination with heat synergistically potentiated heat‐induced cellular killing despite an increase in the expression of Hsp72 and Hsp27 caused by radicicol. Heat alone activated Raf‐1 and p42/p44 extracellular signal‐regulated kinase (Erk), and heat in combination with radicicol inhibited the activation of Raf‐1 and p42/p44 Erk through reduced binding of Raf‐1 to Hsp90. Phosphorylation of Akt was also decreased by radicicol.Conclusions: The Hsp90 chaperone complex inhibitor, radicicol, potentiated heat‐induced cellular killing, and inhibition of p42/p44 Erk and Akt activation rather than modification of Hsp expression might be involved in enhancing cellular thermosensitivity. Results suggest that the Hsp90 chaperone complex could be a new molecular target for the modification of the cellular response to heat." @default.
• W2026007973 created "2016-06-24" @default.
• W2026007973 creator A5020475123 @default.
• W2026007973 creator A5024928773 @default.
• W2026007973 creator A5043131068 @default.
• W2026007973 creator A5064137103 @default.
• W2026007973 creator A5070377660 @default.
• W2026007973 creator A5074150160 @default.
• W2026007973 date "2004-07-01" @default.
• W2026007973 modified "2023-10-15" @default.
• W2026007973 title "Radicicol potentiates heat‐induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity" @default.
• W2026007973 cites W1541948779 @default.
• W2026007973 cites W1963752485 @default.
• W2026007973 cites W1972115601 @default.
• W2026007973 cites W2002079983 @default.
• W2026007973 cites W2042502745 @default.
• W2026007973 cites W2049546697 @default.
• W2026007973 cites W2059524588 @default.
• W2026007973 cites W2061738083 @default.
• W2026007973 cites W2074579328 @default.
• W2026007973 cites W2092025619 @default.
• W2026007973 cites W2092574208 @default.
• W2026007973 cites W2095529319 @default.
• W2026007973 cites W2101549195 @default.
• W2026007973 cites W2137819605 @default.
• W2026007973 cites W2160364430 @default.
• W2026007973 cites W2162107265 @default.
• W2026007973 cites W2173081403 @default.
• W2026007973 cites W2319589010 @default.
• W2026007973 cites W2324191190 @default.
• W2026007973 cites W71667892 @default.
• W2026007973 doi "https://doi.org/10.1080/09553000410001725107" @default.
• W2026007973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15360086" @default.
• W2026007973 hasPublicationYear "2004" @default.
• W2026007973 type Work @default.
• W2026007973 sameAs 2026007973 @default.
• W2026007973 citedByCount "13" @default.
• W2026007973 countsByYear W20260079732012 @default.
• W2026007973 countsByYear W20260079732013 @default.
• W2026007973 countsByYear W20260079732014 @default.
• W2026007973 countsByYear W20260079732015 @default.
• W2026007973 countsByYear W20260079732022 @default.
• W2026007973 crossrefType "journal-article" @default.
• W2026007973 hasAuthorship W2026007973A5020475123 @default.
• W2026007973 hasAuthorship W2026007973A5024928773 @default.
• W2026007973 hasAuthorship W2026007973A5043131068 @default.
• W2026007973 hasAuthorship W2026007973A5064137103 @default.
• W2026007973 hasAuthorship W2026007973A5070377660 @default.
• W2026007973 hasAuthorship W2026007973A5074150160 @default.
• W2026007973 hasConcept C104317684 @default.
• W2026007973 hasConcept C137984847 @default.
• W2026007973 hasConcept C142724271 @default.
• W2026007973 hasConcept C153911025 @default.
• W2026007973 hasConcept C185592680 @default.
• W2026007973 hasConcept C205260736 @default.
• W2026007973 hasConcept C2775932338 @default.
• W2026007973 hasConcept C2775962898 @default.
• W2026007973 hasConcept C2776415932 @default.
• W2026007973 hasConcept C2777560012 @default.
• W2026007973 hasConcept C2779559962 @default.
• W2026007973 hasConcept C54355233 @default.
• W2026007973 hasConcept C55493867 @default.
• W2026007973 hasConcept C57074206 @default.
• W2026007973 hasConcept C62478195 @default.
• W2026007973 hasConcept C68991219 @default.
• W2026007973 hasConcept C71924100 @default.
• W2026007973 hasConcept C75217442 @default.
• W2026007973 hasConcept C81885089 @default.
• W2026007973 hasConcept C86803240 @default.
• W2026007973 hasConcept C95444343 @default.
• W2026007973 hasConceptScore W2026007973C104317684 @default.
• W2026007973 hasConceptScore W2026007973C137984847 @default.
• W2026007973 hasConceptScore W2026007973C142724271 @default.
• W2026007973 hasConceptScore W2026007973C153911025 @default.
• W2026007973 hasConceptScore W2026007973C185592680 @default.
• W2026007973 hasConceptScore W2026007973C205260736 @default.
• W2026007973 hasConceptScore W2026007973C2775932338 @default.
• W2026007973 hasConceptScore W2026007973C2775962898 @default.
• W2026007973 hasConceptScore W2026007973C2776415932 @default.
• W2026007973 hasConceptScore W2026007973C2777560012 @default.
• W2026007973 hasConceptScore W2026007973C2779559962 @default.
• W2026007973 hasConceptScore W2026007973C54355233 @default.
• W2026007973 hasConceptScore W2026007973C55493867 @default.
• W2026007973 hasConceptScore W2026007973C57074206 @default.
• W2026007973 hasConceptScore W2026007973C62478195 @default.
• W2026007973 hasConceptScore W2026007973C68991219 @default.
• W2026007973 hasConceptScore W2026007973C71924100 @default.
• W2026007973 hasConceptScore W2026007973C75217442 @default.
• W2026007973 hasConceptScore W2026007973C81885089 @default.
• W2026007973 hasConceptScore W2026007973C86803240 @default.
• W2026007973 hasConceptScore W2026007973C95444343 @default.
• W2026007973 hasIssue "7" @default.
• W2026007973 hasLocation W20260079731 @default.
• W2026007973 hasLocation W20260079732 @default.
• W2026007973 hasOpenAccess W2026007973 @default.
• W2026007973 hasPrimaryLocation W20260079731 @default.
• W2026007973 hasRelatedWork W157115903 @default.
• W2026007973 hasRelatedWork W2010809759 @default.

• next