FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026009066> ?p ?o ?g. }

• W2026009066 abstract "Abstract Background As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated. FGFs are known to play diverse roles in many processes, including mesoderm induction, branching morphogenesis, organ formation, wound healing and malignant transformation; yet much more remains to be learned about the mechanisms of regulation used to control FGF activity. Results In this work, we conducted an analysis of the functional domains of two Drosophila proteins, Thisbe (Ths) and Pyramus (Pyr), which share homology with the FGF8 subfamily of ligands in vertebrates. Ths and Pyr proteins are secreted from Drosophila Schneider cells (S2) as smaller N-terminal fragments presumably as a result of intracellular proteolytic cleavage. Cleaved forms of Ths and Pyr can be detected in embryonic extracts as well. The FGF-domain is contained within the secreted ligand portion, and this domain alone is capable of functioning in the embryo when ectopically expressed. Through targeted ectopic expression experiments in which we assay the ability of full-length, truncated, and chimeric proteins to support cell differentiation, we find evidence that (1) the C-terminal domain of Pyr is retained inside the cell and does not seem to be required for receptor activation and (2) the C-terminal domain of Ths is secreted and, while also not required for receptor activation, this domain does plays a role in limiting the activity of Ths when present. Conclusions We propose that differential protein processing may account for the previously observed inequalities in signaling capabilities between Ths and Pyr. While the regulatory mechanisms are likely complex, studies such as ours conducted in a tractable model system may be able to provide insights into how ligand processing regulates growth factor activity." @default.
• W2026009066 created "2016-06-24" @default.
• W2026009066 creator A5005248189 @default.
• W2026009066 creator A5086093847 @default.
• W2026009066 date "2010-08-05" @default.
• W2026009066 modified "2023-09-27" @default.
• W2026009066 title "Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs" @default.
• W2026009066 cites W1530921588 @default.
• W2026009066 cites W1872249632 @default.
• W2026009066 cites W1967485093 @default.
• W2026009066 cites W1970147973 @default.
• W2026009066 cites W1970305413 @default.
• W2026009066 cites W1972509609 @default.
• W2026009066 cites W1975304761 @default.
• W2026009066 cites W1977746306 @default.
• W2026009066 cites W1983896852 @default.
• W2026009066 cites W1998904944 @default.
• W2026009066 cites W2006136865 @default.
• W2026009066 cites W2007821628 @default.
• W2026009066 cites W2011750892 @default.
• W2026009066 cites W2017827529 @default.
• W2026009066 cites W2018487851 @default.
• W2026009066 cites W2022114463 @default.
• W2026009066 cites W2023554033 @default.
• W2026009066 cites W2028673763 @default.
• W2026009066 cites W2032056947 @default.
• W2026009066 cites W2036311400 @default.
• W2026009066 cites W2046469335 @default.
• W2026009066 cites W2047958956 @default.
• W2026009066 cites W2050032205 @default.
• W2026009066 cites W2052112605 @default.
• W2026009066 cites W2054809740 @default.
• W2026009066 cites W2056983875 @default.
• W2026009066 cites W2061738087 @default.
• W2026009066 cites W2062808764 @default.
• W2026009066 cites W2065697210 @default.
• W2026009066 cites W2066749061 @default.
• W2026009066 cites W2069064984 @default.
• W2026009066 cites W2081554709 @default.
• W2026009066 cites W2082195162 @default.
• W2026009066 cites W2082342604 @default.
• W2026009066 cites W2084957323 @default.
• W2026009066 cites W2085598440 @default.
• W2026009066 cites W2086029024 @default.
• W2026009066 cites W2091630371 @default.
• W2026009066 cites W2091641911 @default.
• W2026009066 cites W2091948921 @default.
• W2026009066 cites W2093376914 @default.
• W2026009066 cites W2100549778 @default.
• W2026009066 cites W2100585860 @default.
• W2026009066 cites W2100860947 @default.
• W2026009066 cites W2101159637 @default.
• W2026009066 cites W2103118693 @default.
• W2026009066 cites W2104036987 @default.
• W2026009066 cites W2104244040 @default.
• W2026009066 cites W2109412588 @default.
• W2026009066 cites W2122892477 @default.
• W2026009066 cites W2125216271 @default.
• W2026009066 cites W2126359011 @default.
• W2026009066 cites W2133274338 @default.
• W2026009066 cites W2150675831 @default.
• W2026009066 cites W2152207415 @default.
• W2026009066 cites W2152485688 @default.
• W2026009066 cites W2157700111 @default.
• W2026009066 cites W2159028435 @default.
• W2026009066 cites W2159534153 @default.
• W2026009066 cites W2165227826 @default.
• W2026009066 cites W2167853762 @default.
• W2026009066 cites W2172200321 @default.
• W2026009066 doi "https://doi.org/10.1186/1471-213x-10-83" @default.
• W2026009066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2923630" @default.
• W2026009066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20687959" @default.
• W2026009066 hasPublicationYear "2010" @default.
• W2026009066 type Work @default.
• W2026009066 sameAs 2026009066 @default.
• W2026009066 citedByCount "13" @default.
• W2026009066 countsByYear W20260090662012 @default.
• W2026009066 countsByYear W20260090662013 @default.
• W2026009066 countsByYear W20260090662014 @default.
• W2026009066 countsByYear W20260090662015 @default.
• W2026009066 countsByYear W20260090662016 @default.
• W2026009066 countsByYear W20260090662018 @default.
• W2026009066 countsByYear W20260090662019 @default.
• W2026009066 countsByYear W20260090662020 @default.
• W2026009066 countsByYear W20260090662021 @default.
• W2026009066 crossrefType "journal-article" @default.
• W2026009066 hasAuthorship W2026009066A5005248189 @default.
• W2026009066 hasAuthorship W2026009066A5086093847 @default.
• W2026009066 hasBestOaLocation W20260090661 @default.
• W2026009066 hasConcept C104317684 @default.
• W2026009066 hasConcept C145103041 @default.
• W2026009066 hasConcept C170493617 @default.
• W2026009066 hasConcept C183074962 @default.
• W2026009066 hasConcept C2778386714 @default.
• W2026009066 hasConcept C2780915607 @default.
• W2026009066 hasConcept C40692019 @default.
• W2026009066 hasConcept C54355233 @default.
• W2026009066 hasConcept C74373430 @default.
• W2026009066 hasConcept C86803240 @default.
• W2026009066 hasConcept C95444343 @default.

• next