Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026011395> ?p ?o ?g. }
- W2026011395 endingPage "1108" @default.
- W2026011395 startingPage "1102" @default.
- W2026011395 abstract "The phytohormone abscisic acid (ABA) functions through a family of fourteen PYR/PYL receptors, which were identified by resistance to pyrabactin, a synthetic inhibitor of seed germination. ABA activates these receptors to inhibit type 2C protein phosphatases, such as ABI1, yet it remains unclear whether these receptors can be antagonized. Here we demonstrate that pyrabactin is an agonist of PYR1 and PYL1 but is unexpectedly an antagonist of PYL2. Crystal structures of the PYL2-pyrabactin and PYL1-pyrabactin-ABI1 complexes reveal the mechanism responsible for receptor-selective activation and inhibition, which enables us to design mutations that convert PYL1 to a pyrabactin-inhibited receptor and PYL2 to a pyrabactin-activated receptor and to identify new pyrabactin-based ABA receptor agonists. Together, our results establish a new concept of ABA receptor antagonism, illustrate its underlying mechanisms and provide a rational framework for discovering novel ABA receptor ligands." @default.
- W2026011395 created "2016-06-24" @default.
- W2026011395 creator A5000875956 @default.
- W2026011395 creator A5004149609 @default.
- W2026011395 creator A5008658344 @default.
- W2026011395 creator A5008797275 @default.
- W2026011395 creator A5012131365 @default.
- W2026011395 creator A5018691719 @default.
- W2026011395 creator A5027835055 @default.
- W2026011395 creator A5037996538 @default.
- W2026011395 creator A5038468299 @default.
- W2026011395 creator A5045460299 @default.
- W2026011395 creator A5061092892 @default.
- W2026011395 creator A5062671199 @default.
- W2026011395 creator A5063409212 @default.
- W2026011395 creator A5081066698 @default.
- W2026011395 date "2010-08-22" @default.
- W2026011395 modified "2023-10-06" @default.
- W2026011395 title "Identification and mechanism of ABA receptor antagonism" @default.
- W2026011395 cites W1680516124 @default.
- W2026011395 cites W1970236999 @default.
- W2026011395 cites W1971314565 @default.
- W2026011395 cites W1974131529 @default.
- W2026011395 cites W1978838242 @default.
- W2026011395 cites W1995017064 @default.
- W2026011395 cites W1997038372 @default.
- W2026011395 cites W1999590520 @default.
- W2026011395 cites W2003933460 @default.
- W2026011395 cites W2010357923 @default.
- W2026011395 cites W2021698764 @default.
- W2026011395 cites W2047178378 @default.
- W2026011395 cites W2060396596 @default.
- W2026011395 cites W2060849555 @default.
- W2026011395 cites W2077705954 @default.
- W2026011395 cites W2078163944 @default.
- W2026011395 cites W2078821795 @default.
- W2026011395 cites W2078929441 @default.
- W2026011395 cites W2083479533 @default.
- W2026011395 cites W2095811247 @default.
- W2026011395 cites W2106396116 @default.
- W2026011395 cites W2109411650 @default.
- W2026011395 cites W2119612994 @default.
- W2026011395 cites W2122453430 @default.
- W2026011395 cites W2133653666 @default.
- W2026011395 cites W2133674126 @default.
- W2026011395 cites W2138032440 @default.
- W2026011395 cites W2144081223 @default.
- W2026011395 cites W2152295330 @default.
- W2026011395 cites W2152972832 @default.
- W2026011395 cites W2155619616 @default.
- W2026011395 cites W2156166308 @default.
- W2026011395 cites W2161528588 @default.
- W2026011395 cites W2163341755 @default.
- W2026011395 cites W2167417738 @default.
- W2026011395 doi "https://doi.org/10.1038/nsmb.1887" @default.
- W2026011395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933329" @default.
- W2026011395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729862" @default.
- W2026011395 hasPublicationYear "2010" @default.
- W2026011395 type Work @default.
- W2026011395 sameAs 2026011395 @default.
- W2026011395 citedByCount "139" @default.
- W2026011395 countsByYear W20260113952012 @default.
- W2026011395 countsByYear W20260113952013 @default.
- W2026011395 countsByYear W20260113952014 @default.
- W2026011395 countsByYear W20260113952015 @default.
- W2026011395 countsByYear W20260113952016 @default.
- W2026011395 countsByYear W20260113952017 @default.
- W2026011395 countsByYear W20260113952018 @default.
- W2026011395 countsByYear W20260113952019 @default.
- W2026011395 countsByYear W20260113952020 @default.
- W2026011395 countsByYear W20260113952021 @default.
- W2026011395 countsByYear W20260113952022 @default.
- W2026011395 countsByYear W20260113952023 @default.
- W2026011395 crossrefType "journal-article" @default.
- W2026011395 hasAuthorship W2026011395A5000875956 @default.
- W2026011395 hasAuthorship W2026011395A5004149609 @default.
- W2026011395 hasAuthorship W2026011395A5008658344 @default.
- W2026011395 hasAuthorship W2026011395A5008797275 @default.
- W2026011395 hasAuthorship W2026011395A5012131365 @default.
- W2026011395 hasAuthorship W2026011395A5018691719 @default.
- W2026011395 hasAuthorship W2026011395A5027835055 @default.
- W2026011395 hasAuthorship W2026011395A5037996538 @default.
- W2026011395 hasAuthorship W2026011395A5038468299 @default.
- W2026011395 hasAuthorship W2026011395A5045460299 @default.
- W2026011395 hasAuthorship W2026011395A5061092892 @default.
- W2026011395 hasAuthorship W2026011395A5062671199 @default.
- W2026011395 hasAuthorship W2026011395A5063409212 @default.
- W2026011395 hasAuthorship W2026011395A5081066698 @default.
- W2026011395 hasBestOaLocation W20260113952 @default.
- W2026011395 hasConcept C104317684 @default.
- W2026011395 hasConcept C11960822 @default.
- W2026011395 hasConcept C170493617 @default.
- W2026011395 hasConcept C178666793 @default.
- W2026011395 hasConcept C185592680 @default.
- W2026011395 hasConcept C2777383412 @default.
- W2026011395 hasConcept C2778938600 @default.
- W2026011395 hasConcept C2779591172 @default.
- W2026011395 hasConcept C55493867 @default.