FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026012491> ?p ?o ?g. }

• W2026012491 endingPage "639" @default.
• W2026012491 startingPage "636" @default.
• W2026012491 abstract "We developed phase-switch microfluidic devices for molecular profiling of a large number of single cells. Whole genome microarrays and RNA-sequencing are commonly used to determine the expression levels of genes in cell lysates (a physical mix of millions of cells) for inferring gene functions. However, cellular heterogeneity becomes an inherent noise in the measurement of gene expression. The unique molecular characteristics of individual cells, as well as the temporal and quantitative information of gene expression in cells, are lost when averaged among all cells in cell lysates. Our single-cell technology overcomes this limitation and enables us to obtain a large number of single-cell transcriptomes from a population of cells. A collection of single-cell molecular profiles allows us to study carcinogenesis from an evolutionary perspective by treating cancer as a diverse population of cells with abnormal molecular characteristics. Because a cancer cell population contains cells at various stages of development toward drug resistance, clustering similar single-cell molecular profiles could reveal how drug-resistant sub-clones evolve during cancer treatment. Here, we discuss how single-cell transcriptome analysis technology could enable the study of carcinogenesis from an evolutionary perspective and the development of drug-resistance in leukemia. The single-cell transcriptome analysis reported here could have a direct and significant impact on current cancer treatments and future personalized cancer therapies." @default.
• W2026012491 created "2016-06-24" @default.
• W2026012491 creator A5007747899 @default.
• W2026012491 creator A5048261406 @default.
• W2026012491 creator A5056085493 @default.
• W2026012491 creator A5062631778 @default.
• W2026012491 creator A5070538645 @default.
• W2026012491 creator A5082312520 @default.
• W2026012491 date "2013-12-05" @default.
• W2026012491 modified "2023-09-27" @default.
• W2026012491 title "Investigating evolutionary perspective of carcinogenesis with single-cell transcriptome analysis" @default.
• W2026012491 cites W1490860457 @default.
• W2026012491 cites W1514208610 @default.
• W2026012491 cites W1966460887 @default.
• W2026012491 cites W1973689090 @default.
• W2026012491 cites W1986944049 @default.
• W2026012491 cites W1987239635 @default.
• W2026012491 cites W2001627351 @default.
• W2026012491 cites W2008487941 @default.
• W2026012491 cites W2011188089 @default.
• W2026012491 cites W2013225336 @default.
• W2026012491 cites W2013537058 @default.
• W2026012491 cites W2021648831 @default.
• W2026012491 cites W2026235225 @default.
• W2026012491 cites W2035379944 @default.
• W2026012491 cites W2040458067 @default.
• W2026012491 cites W2041004587 @default.
• W2026012491 cites W2048258225 @default.
• W2026012491 cites W2050545728 @default.
• W2026012491 cites W2054251966 @default.
• W2026012491 cites W2055565290 @default.
• W2026012491 cites W2067432815 @default.
• W2026012491 cites W2075580305 @default.
• W2026012491 cites W2080125373 @default.
• W2026012491 cites W2087249042 @default.
• W2026012491 cites W2088430282 @default.
• W2026012491 cites W2088722607 @default.
• W2026012491 cites W2091653492 @default.
• W2026012491 cites W2098255859 @default.
• W2026012491 cites W2107268345 @default.
• W2026012491 cites W2116298078 @default.
• W2026012491 cites W2117637538 @default.
• W2026012491 cites W2119739306 @default.
• W2026012491 cites W2127375899 @default.
• W2026012491 cites W2128833602 @default.
• W2026012491 cites W2139790154 @default.
• W2026012491 cites W2144755648 @default.
• W2026012491 cites W2150575159 @default.
• W2026012491 cites W2168373302 @default.
• W2026012491 cites W2274051453 @default.
• W2026012491 cites W2419024714 @default.
• W2026012491 cites W3021649819 @default.
• W2026012491 doi "https://doi.org/10.5732/cjc.012.10291" @default.
• W2026012491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3870846" @default.
• W2026012491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23706768" @default.
• W2026012491 hasPublicationYear "2013" @default.
• W2026012491 type Work @default.
• W2026012491 sameAs 2026012491 @default.
• W2026012491 citedByCount "6" @default.
• W2026012491 countsByYear W20260124912014 @default.
• W2026012491 countsByYear W20260124912016 @default.
• W2026012491 countsByYear W20260124912017 @default.
• W2026012491 countsByYear W20260124912020 @default.
• W2026012491 crossrefType "journal-article" @default.
• W2026012491 hasAuthorship W2026012491A5007747899 @default.
• W2026012491 hasAuthorship W2026012491A5048261406 @default.
• W2026012491 hasAuthorship W2026012491A5056085493 @default.
• W2026012491 hasAuthorship W2026012491A5062631778 @default.
• W2026012491 hasAuthorship W2026012491A5070538645 @default.
• W2026012491 hasAuthorship W2026012491A5082312520 @default.
• W2026012491 hasBestOaLocation W20260124911 @default.
• W2026012491 hasConcept C104317684 @default.
• W2026012491 hasConcept C121608353 @default.
• W2026012491 hasConcept C1491633281 @default.
• W2026012491 hasConcept C150194340 @default.
• W2026012491 hasConcept C162317418 @default.
• W2026012491 hasConcept C16671776 @default.
• W2026012491 hasConcept C174749747 @default.
• W2026012491 hasConcept C18431079 @default.
• W2026012491 hasConcept C2776950831 @default.
• W2026012491 hasConcept C2908647359 @default.
• W2026012491 hasConcept C501734568 @default.
• W2026012491 hasConcept C54355233 @default.
• W2026012491 hasConcept C555283112 @default.
• W2026012491 hasConcept C70721500 @default.
• W2026012491 hasConcept C71924100 @default.
• W2026012491 hasConcept C86803240 @default.
• W2026012491 hasConcept C95371953 @default.
• W2026012491 hasConcept C96232424 @default.
• W2026012491 hasConcept C99454951 @default.
• W2026012491 hasConceptScore W2026012491C104317684 @default.
• W2026012491 hasConceptScore W2026012491C121608353 @default.
• W2026012491 hasConceptScore W2026012491C1491633281 @default.
• W2026012491 hasConceptScore W2026012491C150194340 @default.
• W2026012491 hasConceptScore W2026012491C162317418 @default.
• W2026012491 hasConceptScore W2026012491C16671776 @default.
• W2026012491 hasConceptScore W2026012491C174749747 @default.
• W2026012491 hasConceptScore W2026012491C18431079 @default.

• next