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• W2026016104 abstract "A water soluble 1,3,5-triazine-based copper(II) complex, [Cu(tptz) 2 ] 2+ , where tptz is 2,4,6-tris(2-pyridyl)-1,3,5-triazine, has been prepared and characterized by elemental analysis and spectroscopic methods. Its DNA binding propensity and in vitro cytotoxicity have also been studied. The molecular structure shows a compressed octahedral CuN 6 coordination geometry as a consequence of strain imposed by the rigid ligands. ► Synthesis and characterization of a water soluble 1,3,5-triazine-based copper(II) complex, [Cu(tptz) 2 ] 2+ . ► Single-crystal X-ray crystallography for this complex. ► The molecular structure shows a compressed octahedral CuN 6 coordination geometry. ► Investigation of DNA–complex interaction by spectroscopic, electrochemical and gel electrophoresis methods. ► An in vitro cytotoxicity study on a human breast adenocarcinoma with an IC 50 better than cis platin. A water soluble 1,3,5-triazine-based copper(II) complex, [Cu(tptz) 2 ] 2+ , where tptz is 2,4,6-tris(2-pyridyl)-1,3,5-triazine, has been prepared and characterized by elemental analysis and spectroscopic methods. The solid state structure of the complex as the hexafluorophosphate salt has been determined by single-crystal X-ray crystallography. Its DNA binding propensity and in vitro cytotoxicity have also been studied. The molecular structure shows a compressed octahedral CuN 6 coordination geometry as a consequence of strain imposed by the rigid ligands. The interaction of the complex with DNA has been investigated by electronic absorption, competitive fluorescence titration, voltammetric techniques and a gel electrophoresis mobility shift assay. The results reveal that the complex binds to DNA in a moderately strong fashion via intercalation with the partial insertion of a planar polypyridyl ligand between the base stacks of double-stranded DNA. An in vitro cytotoxicity study of the effect of the complex on a human breast adenocarcinoma (MCF-7) cell line by an MTT assay indicates that the complex exhibits a marked cell growth-inhibitory effect with an IC 50 value of 1.98 μM, which is significantly better than that observed for cis platin." @default.
• W2026016104 created "2016-06-24" @default.
• W2026016104 creator A5003917349 @default.
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• W2026016104 date "2012-08-01" @default.
• W2026016104 modified "2023-10-17" @default.
• W2026016104 title "A mononuclear copper(II) complex based on the polypyridyl ligand 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz), [Cu(tptz)2]2+: X-ray crystal structure, DNA binding and in vitro cell cytotoxicity" @default.
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• W2026016104 doi "https://doi.org/10.1016/j.poly.2012.06.089" @default.
• W2026016104 hasPublicationYear "2012" @default.
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