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• W2026021068 abstract "The addition of fatty acid, ATP, Mg2+ and CoA to a rat liver mitochondrial suspension promoted swelling of the mitochondria which was reversed by the addition of carnitine. The carnitine-mediated contraction was blocked by respiratory inhibitors, and was accompanied by an increased formation of mitochondrial fatty acyl carnitine. When palmityl (l) carnitine or palmityl CoA in the presence of carnitine were used as swelling agents a spontaneous contraction of the mitochondria was observed which was independent of added ATP. Under these conditions the contraction was insensitive to oligomycin, but was inhibited by dinitrophenol or respiratory inhibitors. The results suggest that reversal of fatty acid-induced swelling may be linked to the transfer of fatty acyl groups across mitochondrial permeability barriers, and that the energy requirement for contraction may be derived from reactions coupled to fatty acid oxidation." @default.
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• W2026021068 date "1968-08-01" @default.
• W2026021068 modified "2023-09-26" @default.
• W2026021068 title "The effect of carnitine, fatty acyl carnitine, and fatty acyl coenzyme A on mitochondrial contraction" @default.
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• W2026021068 doi "https://doi.org/10.1016/0003-9861(68)90450-5" @default.
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