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- W2026021908 abstract "The effects of the 5-HT1B receptor agonist CP-94,253 were compared with those of the mixed β-adrenoceptor and 5-HT1A/B receptor antagonist (±)pindolol in rats implanted for chronic sleep recordings. CP-94,253 (5.0–10.0 mg/kg) significantly increased waking and reduced slow wave sleep (SWS) and REM sleep (REMS). At 2.0–4.0 mg/kg (±)pindolol reduced REMS. Pretreatment with (±)pindolol (2.0–4.0 mg/kg) reversed the effect of CP-94,253 on waking and SWS, while REMS remained suppressed. It is suggested that the 5-HT1B receptor together with other 5-HT receptor subtypes may have a direct regulatory action on sleep and waking in the rat." @default.
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- W2026021908 date "1995-12-01" @default.
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- W2026021908 title "Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat" @default.
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