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- W2026028041 abstract "Evidence is lacking that they are better than cheaper standard treatmentHyponatraemia is the most common electrolyte abnormality, especially in patients in hospital,1 and it is associated with substantial morbidity and mortality.2 The causes of hyponatraemia are often difficult to ascertain and may be multifactorial. Treatment varies according to the cause, severity of symptoms, and speed of onset. Tolvaptan, a vasopressin 2 receptor antagonist, has recently been licensed in the United Kingdom for the treatment of hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormone secretion⇓.OtsukaArginine vasopressin, also known as antidiuretic hormone, regulates the renal clearance of free water. Raised concentrations of arginine vasopressin cause the kidneys to retain water, and disorders of its release and regulation cause an imbalance in total body water. Vasopressin 2 receptors are found mainly in the collecting ducts of the kidneys, where they control free water reabsorption. These receptors have been targeted by non-peptide vasopressin 2 receptor antagonists, which promote the excretion of water without loss of electrolytes. These agents were originally developed for the treatment of hyponatraemia as a result of heart failure, decompensated cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion.Tolvaptan was licensed after completion of …" @default.
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- W2026028041 date "2010-11-15" @default.
- W2026028041 modified "2023-09-25" @default.
- W2026028041 title "New drugs for hyponatraemia" @default.
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- W2026028041 doi "https://doi.org/10.1136/bmj.c6219" @default.
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