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• W2026035148 abstract "Objective: The objective of this retrospective controlled study was to compare the efficacy and safety of ovulation induction with CC versus TMX in a population of anovulatory infertile women with PCOS.Design: Retrospective observational study.Materials and Methods: Between July 2001 and December 2002, one hundred two consecutive women (mean age ± SD: 31 ± 3.6 years; range 26–38) with PCOS referred to the infertility clinic were studied. Inclusion criteria were as follows: age below 40 years, bilateral tubal patency, biochemical indices and ultrasonographic features of PCOS and no any other endocrinopathy. Following a spontaneous or progesterone-induced withdrawal bleed, women received either 50mg daily CC during cycle days 2 to 6 or 20mg daily TMX during cycle days 2 to 5. In case ovulation failed to occur with the initial dose of either drug, then the dose was sequentially increased to 100mg daily CC and 40mg daily TMX, respectively. All women were instructed to have a blood test for progesterone measurement on cycle day 21. Serum progesterone levels ≥ 30nmol/l were considered to be presumptive evidence of ovulation. Data were analysed using ANOVA and Fisher exact test. Significance was assumed at p < 0.05.Results: Fifty-nine women received CC and 43 received TMX. The total number of treatment cycles with CC and TMX was 127 and 98, respectively. The overall rate of ovulation in the CC-group was 60 of 127 (47.2%) and in the TMX-group was 61 of 98 (62.2%) (OR, 0.54; 95% CI, 0.31–0.92; p = 0.03). The ovulatory rate per cycle with low-dose CC and TMX was 42.8% and 67.2% (OR, 0.36; 95% CI, 0.17–0.77; p = 0.009), respectively. In contrast, there was no significant difference when comparing high-dose CC and TMX (50.7% and 54%, respectively). The cumulative pregnancy rate per ovulatory cycle was 11 of 60 (18.3%) in the CC-group and 14 of 61 (22.9%) in the TMX-group (p > 0.05). All pregnancies were single and there were no remarkable side effects in either group of treatment.Conclusion: The overall ovulation rate was significantly higher in women who received TMX compared with those who received CC. In addition, ovulatory rate per cycle was significantly higher with low-dose TMX compared to CC. Despite these agents have previously been reported to be equally effective in the management of anovulatory PCOS women, this study suggests that TMX has the same safety but better efficacy than CC for ovulation induction. Objective: The objective of this retrospective controlled study was to compare the efficacy and safety of ovulation induction with CC versus TMX in a population of anovulatory infertile women with PCOS. Design: Retrospective observational study. Materials and Methods: Between July 2001 and December 2002, one hundred two consecutive women (mean age ± SD: 31 ± 3.6 years; range 26–38) with PCOS referred to the infertility clinic were studied. Inclusion criteria were as follows: age below 40 years, bilateral tubal patency, biochemical indices and ultrasonographic features of PCOS and no any other endocrinopathy. Following a spontaneous or progesterone-induced withdrawal bleed, women received either 50mg daily CC during cycle days 2 to 6 or 20mg daily TMX during cycle days 2 to 5. In case ovulation failed to occur with the initial dose of either drug, then the dose was sequentially increased to 100mg daily CC and 40mg daily TMX, respectively. All women were instructed to have a blood test for progesterone measurement on cycle day 21. Serum progesterone levels ≥ 30nmol/l were considered to be presumptive evidence of ovulation. Data were analysed using ANOVA and Fisher exact test. Significance was assumed at p < 0.05. Results: Fifty-nine women received CC and 43 received TMX. The total number of treatment cycles with CC and TMX was 127 and 98, respectively. The overall rate of ovulation in the CC-group was 60 of 127 (47.2%) and in the TMX-group was 61 of 98 (62.2%) (OR, 0.54; 95% CI, 0.31–0.92; p = 0.03). The ovulatory rate per cycle with low-dose CC and TMX was 42.8% and 67.2% (OR, 0.36; 95% CI, 0.17–0.77; p = 0.009), respectively. In contrast, there was no significant difference when comparing high-dose CC and TMX (50.7% and 54%, respectively). The cumulative pregnancy rate per ovulatory cycle was 11 of 60 (18.3%) in the CC-group and 14 of 61 (22.9%) in the TMX-group (p > 0.05). All pregnancies were single and there were no remarkable side effects in either group of treatment. Conclusion: The overall ovulation rate was significantly higher in women who received TMX compared with those who received CC. In addition, ovulatory rate per cycle was significantly higher with low-dose TMX compared to CC. Despite these agents have previously been reported to be equally effective in the management of anovulatory PCOS women, this study suggests that TMX has the same safety but better efficacy than CC for ovulation induction." @default.
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• W2026035148 date "2003-09-01" @default.
• W2026035148 modified "2023-09-30" @default.
• W2026035148 title "Ovulation induction in anovulatory women with polycystic ovary syndrome: comparison between clomiphene citrate and tamoxifen citrate" @default.
• W2026035148 doi "https://doi.org/10.1016/s0015-0282(03)01696-0" @default.
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