Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026044237> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2026044237 endingPage "0" @default.
- W2026044237 startingPage "0" @default.
- W2026044237 abstract "Acute adenovirus ocular infections are the most common ocular viral infections worldwide and are associated with community and medical facility epidemics. While not permanently blinding, ocular adenoviral infections are associated with significant patient morbidity, including symptomatic distress with visual disturbances which can last years, and loss of time from school or work. Currently, the treatment of these acute infections is symptomatic due to the lack of an approved antiviral. This symptomatic treatment presents a controversy of whether to treat these viral infections with immunomodulating agents (e.g. topical corticosteroids, NSAIDs, cyclosporine A), which are contraindicated for use in the treatment of the other major external ocular viral infection, HSV-1 epithelial keratitis. The adenovirus type 5 (Ad5)/New Zealand White (NZW) rabbit ocular model has provided data for potential clinical guidelines for the use of immunomodulating agents in the treatment of adenovirus ocular infections. Moreover, this model has been used extensively to evaluate promising candidate antivirals for adenovirus. Multiple candidate antivirals have been evaluated in vivo using this model, and several have proceeded to human clinical trials. The current presentation will discuss the potential clinical guidelines for the use of immunomodulating agents, present data on potential new topical antiviral agents, discuss the potential combination therapy of an antiviral and immunomodulatory agent in the treatment of adenovirus ocular infections as well as the limitations of the model.Commercial interest" @default.
- W2026044237 created "2016-06-24" @default.
- W2026044237 creator A5068830420 @default.
- W2026044237 date "2010-09-01" @default.
- W2026044237 modified "2023-09-27" @default.
- W2026044237 title "The utility of a rabbit model of adenovirus ocular infection" @default.
- W2026044237 doi "https://doi.org/10.1111/j.1755-3768.2010.2211.x" @default.
- W2026044237 hasPublicationYear "2010" @default.
- W2026044237 type Work @default.
- W2026044237 sameAs 2026044237 @default.
- W2026044237 citedByCount "0" @default.
- W2026044237 crossrefType "journal-article" @default.
- W2026044237 hasAuthorship W2026044237A5068830420 @default.
- W2026044237 hasConcept C126322002 @default.
- W2026044237 hasConcept C16005928 @default.
- W2026044237 hasConcept C177713679 @default.
- W2026044237 hasConcept C203014093 @default.
- W2026044237 hasConcept C2522874641 @default.
- W2026044237 hasConcept C2771230 @default.
- W2026044237 hasConcept C2778560704 @default.
- W2026044237 hasConcept C2781036101 @default.
- W2026044237 hasConcept C535046627 @default.
- W2026044237 hasConcept C71924100 @default.
- W2026044237 hasConceptScore W2026044237C126322002 @default.
- W2026044237 hasConceptScore W2026044237C16005928 @default.
- W2026044237 hasConceptScore W2026044237C177713679 @default.
- W2026044237 hasConceptScore W2026044237C203014093 @default.
- W2026044237 hasConceptScore W2026044237C2522874641 @default.
- W2026044237 hasConceptScore W2026044237C2771230 @default.
- W2026044237 hasConceptScore W2026044237C2778560704 @default.
- W2026044237 hasConceptScore W2026044237C2781036101 @default.
- W2026044237 hasConceptScore W2026044237C535046627 @default.
- W2026044237 hasConceptScore W2026044237C71924100 @default.
- W2026044237 hasLocation W20260442371 @default.
- W2026044237 hasOpenAccess W2026044237 @default.
- W2026044237 hasPrimaryLocation W20260442371 @default.
- W2026044237 hasRelatedWork W1846282383 @default.
- W2026044237 hasRelatedWork W1966678557 @default.
- W2026044237 hasRelatedWork W1970028867 @default.
- W2026044237 hasRelatedWork W1984460735 @default.
- W2026044237 hasRelatedWork W1992023475 @default.
- W2026044237 hasRelatedWork W1993514414 @default.
- W2026044237 hasRelatedWork W2004171661 @default.
- W2026044237 hasRelatedWork W2056088578 @default.
- W2026044237 hasRelatedWork W2160431750 @default.
- W2026044237 hasRelatedWork W2171697673 @default.
- W2026044237 hasRelatedWork W2335210495 @default.
- W2026044237 hasRelatedWork W2400755554 @default.
- W2026044237 hasRelatedWork W2413914666 @default.
- W2026044237 hasRelatedWork W2471148522 @default.
- W2026044237 hasRelatedWork W2557807817 @default.
- W2026044237 hasRelatedWork W2591719693 @default.
- W2026044237 hasRelatedWork W2754199681 @default.
- W2026044237 hasRelatedWork W2767381084 @default.
- W2026044237 hasRelatedWork W3201197918 @default.
- W2026044237 hasRelatedWork W47087790 @default.
- W2026044237 hasVolume "88" @default.
- W2026044237 isParatext "false" @default.
- W2026044237 isRetracted "false" @default.
- W2026044237 magId "2026044237" @default.
- W2026044237 workType "article" @default.