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- W202604683 abstract "Summary Muscle fibers form during embryogenesis by the fusion of mononucleate myoblasts to form multinucleate syncytia. Myoblasts are determined somitic mesoderm cells that migrate to sites of myogenesis throughout the body in a biphasic fashion. Migration to the premuscle masses and the location of myoblasts on the extracellular matrix is controlled by a family of extracellular matrix receptors, the integrins. Fusion of growth-arrested myoblasts is controlled by two complementary adhesion systems—the Ca2+ dependent and Ca2+ independent systems. Progression of myoblasts through the various compartments of myogenesis is controlled by a family of muscle-specific proteins, the bHLH proteins. Following fusion, the newly formed myotubes follow a typical pattern of development based upon their lineage. Mature fibers retain the ability to change their physiological properties in response to environmental cues, which are responsible for building the adult characteristics of the different muscle groups. Postnatal growth occurs in response to a variety of stimuli by the fusion of myoblasts derived from satellite cells associated with adult fibers. In response to muscle damage caused by either mechanical trauma or disease, muscle is capable of regeneration. The process of regeneration mirrors that of myogenesis in the embryo—by fusion of myoblasts derived from the satellite cell population with each other and the damaged fibers. Regeneration of muscle fibers using normal myoblasts injected into diseased muscle (myoblasts transfer therapy or MTT) may be of use in treating inherited muscle diseases. Experimental MTT has already been studied in the disease Duchenne muscular dystrophy with disappointing results in human trials." @default.
- W202604683 created "2016-06-24" @default.
- W202604683 creator A5052817672 @default.
- W202604683 creator A5055891535 @default.
- W202604683 date "1998-01-01" @default.
- W202604683 modified "2023-09-27" @default.
- W202604683 title "Chapter 12 The molecular and cellular biology of skeletal muscle myogenesis" @default.
- W202604683 cites W1514399329 @default.
- W202604683 cites W1520204463 @default.
- W202604683 cites W1587480542 @default.
- W202604683 cites W1617847244 @default.
- W202604683 cites W1845992048 @default.
- W202604683 cites W1899737965 @default.
- W202604683 cites W1956688482 @default.
- W202604683 cites W1965491546 @default.
- W202604683 cites W1966387132 @default.
- W202604683 cites W1966819317 @default.
- W202604683 cites W1970561503 @default.
- W202604683 cites W1973013529 @default.
- W202604683 cites W1974543599 @default.
- W202604683 cites W1979126494 @default.
- W202604683 cites W1979483810 @default.
- W202604683 cites W1979614115 @default.
- W202604683 cites W1981218555 @default.
- W202604683 cites W1982274138 @default.
- W202604683 cites W1986403312 @default.
- W202604683 cites W1986885306 @default.
- W202604683 cites W1988449813 @default.
- W202604683 cites W1991653066 @default.
- W202604683 cites W1994971898 @default.
- W202604683 cites W1997877463 @default.
- W202604683 cites W2000431646 @default.
- W202604683 cites W2001610575 @default.
- W202604683 cites W2005418473 @default.
- W202604683 cites W2005617400 @default.
- W202604683 cites W2006384404 @default.
- W202604683 cites W2009104287 @default.
- W202604683 cites W2010203981 @default.
- W202604683 cites W2013046038 @default.
- W202604683 cites W2013781426 @default.
- W202604683 cites W2017525209 @default.
- W202604683 cites W2017765584 @default.
- W202604683 cites W2018600945 @default.
- W202604683 cites W2021346820 @default.
- W202604683 cites W2022085339 @default.
- W202604683 cites W2026649326 @default.
- W202604683 cites W2032210940 @default.
- W202604683 cites W2034933188 @default.
- W202604683 cites W2037388152 @default.
- W202604683 cites W2041652972 @default.
- W202604683 cites W2042099799 @default.
- W202604683 cites W2042975342 @default.
- W202604683 cites W2043317882 @default.
- W202604683 cites W2043714937 @default.
- W202604683 cites W2046292603 @default.
- W202604683 cites W2051541258 @default.
- W202604683 cites W2057895567 @default.
- W202604683 cites W2059556539 @default.
- W202604683 cites W2060124311 @default.
- W202604683 cites W2062052242 @default.
- W202604683 cites W2063947395 @default.
- W202604683 cites W2066180106 @default.
- W202604683 cites W2068199526 @default.
- W202604683 cites W2068751406 @default.
- W202604683 cites W2069168647 @default.
- W202604683 cites W2072987509 @default.
- W202604683 cites W2075505332 @default.
- W202604683 cites W2076497575 @default.
- W202604683 cites W2077853923 @default.
- W202604683 cites W2078718449 @default.
- W202604683 cites W2080499750 @default.
- W202604683 cites W2081468639 @default.
- W202604683 cites W2082460645 @default.
- W202604683 cites W2082977165 @default.
- W202604683 cites W2087803244 @default.
- W202604683 cites W2087924428 @default.
- W202604683 cites W2092672852 @default.
- W202604683 cites W2095186612 @default.
- W202604683 cites W2102294452 @default.
- W202604683 cites W2112093320 @default.
- W202604683 cites W2113420985 @default.
- W202604683 cites W2122043314 @default.
- W202604683 cites W2123861384 @default.
- W202604683 cites W2124720925 @default.
- W202604683 cites W2124791711 @default.
- W202604683 cites W2129844699 @default.
- W202604683 cites W2130207697 @default.
- W202604683 cites W2133127106 @default.
- W202604683 cites W2133609998 @default.
- W202604683 cites W2137181404 @default.
- W202604683 cites W2138296820 @default.
- W202604683 cites W2145897147 @default.
- W202604683 cites W2153661901 @default.
- W202604683 cites W2156103307 @default.
- W202604683 cites W2164615927 @default.
- W202604683 cites W2165220352 @default.
- W202604683 cites W2176077507 @default.
- W202604683 cites W2177035195 @default.
- W202604683 cites W2184549427 @default.
- W202604683 cites W2246359815 @default.