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- W2026058052 abstract "Les anticorps monoclonaux (Acm) puis l’ingénierie moléculaire ont rénové l’antique sérothérapie, multipliant les possibilités d’intervention thérapeutique et apportant de nouveaux succès cliniques. Mettre en perspective cette histoire permet de mieux appréhender l’évolution des concepts qui sous-tendent l’utilisation thérapeutique des anticorps, tout autant que la maturation de l’outil lui-même. Seront abordés successivement dans cette revue les différents principes de ciblage thérapeutique, depuis leur conception parfois séculaire jusqu’aux derniers développements cliniques : anticorps neutralisant les toxines et les antigènes solubles, anticorps antimicrobiens, anticorps cytotoxiques, anticorps spécifiques de tumeurs, anticorps modifiant les réponses cellulaires, etc. Ce panorama sera enfin l’occasion d’introduire une nouvelle classification pharmacologique de la classe des anticorps thérapeutiques non conjugués." @default.
- W2026058052 created "2016-06-24" @default.
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- W2026058052 date "2009-12-01" @default.
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- W2026058052 title "De la sérothérapie aux anticorps recombinants « nus »" @default.
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- W2026058052 doi "https://doi.org/10.1051/medsci/20092512999" @default.
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