Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026063973> ?p ?o ?g. }
- W2026063973 endingPage "143" @default.
- W2026063973 startingPage "113" @default.
- W2026063973 abstract "Hepatitis B virus (HBV) is at the origin of severe liver diseases like chronic active hepatitis, liver cirrhosis and hepatocellular carcinoma. There are some groups of patients with high risk of generation of HBV mutants: infected infants, immunosupressed individuals (including hemodialysis patients), patients treated with interferon and lamivudine for chronic HBV infection. These groups are the target for molecular investigations reviewed in this paper. The emergence of lamivudine- or other antiviral-resistant variants, rises concern regarding long term use of these drugs. Infection or immunization with one HBV subtype confers immunity to all subtypes. However, reinfection or reactivation of latent HBV infection with HBV mutants have been reported in patients undergoing transplant and those infected with HIV. Mutations of the viral genome which are not replicative incompetent can be selected in further course of infection or under prolonged antiviral treatment and might maintain the liver disease. Four open reading frames (ORF) which are called S-gene, C-gene, X-gene and P-gene were identified within the HBV genome. Mutations may affect each of the ORFs. Mutated S-genes were described to be responsible for HBV-infections in successfully vaccinated persons, mutated C-genes were found to provoke severe chronic liver diseases, mutated X-genes could cause serious medical problemes in blood donors by escaping the conventional test systems and mutated P-genes were considered to be the reason for chemotherapeutic drug resistance. This paper reviews molecular, immunological and clinical aspects of the HBV mutants." @default.
- W2026063973 created "2016-06-24" @default.
- W2026063973 creator A5076933919 @default.
- W2026063973 date "2002-01-01" @default.
- W2026063973 modified "2023-10-14" @default.
- W2026063973 title "Molecular, immunological and clinical properties of mutated hepatitis B viruses" @default.
- W2026063973 cites W106131499 @default.
- W2026063973 cites W10963595 @default.
- W2026063973 cites W1480719064 @default.
- W2026063973 cites W1488842947 @default.
- W2026063973 cites W1501417543 @default.
- W2026063973 cites W1501458422 @default.
- W2026063973 cites W1502620477 @default.
- W2026063973 cites W1519922926 @default.
- W2026063973 cites W1558629099 @default.
- W2026063973 cites W1559614440 @default.
- W2026063973 cites W1582199693 @default.
- W2026063973 cites W1582561043 @default.
- W2026063973 cites W1585184764 @default.
- W2026063973 cites W1585454606 @default.
- W2026063973 cites W1585930597 @default.
- W2026063973 cites W1589359966 @default.
- W2026063973 cites W1593081376 @default.
- W2026063973 cites W1594370719 @default.
- W2026063973 cites W1600467152 @default.
- W2026063973 cites W1600549194 @default.
- W2026063973 cites W1608900367 @default.
- W2026063973 cites W1611884612 @default.
- W2026063973 cites W1656404511 @default.
- W2026063973 cites W1676276742 @default.
- W2026063973 cites W1728137922 @default.
- W2026063973 cites W1782358917 @default.
- W2026063973 cites W1823076085 @default.
- W2026063973 cites W1827821010 @default.
- W2026063973 cites W1841661550 @default.
- W2026063973 cites W1853569310 @default.
- W2026063973 cites W1872095343 @default.
- W2026063973 cites W1875430957 @default.
- W2026063973 cites W1876057216 @default.
- W2026063973 cites W1887371688 @default.
- W2026063973 cites W1893380982 @default.
- W2026063973 cites W1894278338 @default.
- W2026063973 cites W1920847077 @default.
- W2026063973 cites W1922003631 @default.
- W2026063973 cites W1940739348 @default.
- W2026063973 cites W1941412003 @default.
- W2026063973 cites W1955933769 @default.
- W2026063973 cites W1964165326 @default.
- W2026063973 cites W1964288153 @default.
- W2026063973 cites W1964576498 @default.
- W2026063973 cites W1966216311 @default.
- W2026063973 cites W1966886140 @default.
- W2026063973 cites W1969235397 @default.
- W2026063973 cites W1969629866 @default.
- W2026063973 cites W1969791642 @default.
- W2026063973 cites W1969842237 @default.
- W2026063973 cites W1970628640 @default.
- W2026063973 cites W1970968166 @default.
- W2026063973 cites W1971248139 @default.
- W2026063973 cites W1971923366 @default.
- W2026063973 cites W1976532144 @default.
- W2026063973 cites W1976888144 @default.
- W2026063973 cites W1977601063 @default.
- W2026063973 cites W1978703286 @default.
- W2026063973 cites W1981273162 @default.
- W2026063973 cites W1981304628 @default.
- W2026063973 cites W1983130061 @default.
- W2026063973 cites W1983570776 @default.
- W2026063973 cites W1983734380 @default.
- W2026063973 cites W1984533627 @default.
- W2026063973 cites W1985577568 @default.
- W2026063973 cites W1986150533 @default.
- W2026063973 cites W1986188955 @default.
- W2026063973 cites W1986801839 @default.
- W2026063973 cites W1987536971 @default.
- W2026063973 cites W1987815104 @default.
- W2026063973 cites W1988269521 @default.
- W2026063973 cites W1990874299 @default.
- W2026063973 cites W1991293067 @default.
- W2026063973 cites W1991602367 @default.
- W2026063973 cites W1992966878 @default.
- W2026063973 cites W1993455944 @default.
- W2026063973 cites W1994127603 @default.
- W2026063973 cites W1994147351 @default.
- W2026063973 cites W1995509195 @default.
- W2026063973 cites W1996342517 @default.
- W2026063973 cites W199634660 @default.
- W2026063973 cites W1997384064 @default.
- W2026063973 cites W1999263104 @default.
- W2026063973 cites W1999298724 @default.
- W2026063973 cites W2001600181 @default.
- W2026063973 cites W2006595492 @default.
- W2026063973 cites W2006694666 @default.
- W2026063973 cites W2007925721 @default.
- W2026063973 cites W2008573155 @default.
- W2026063973 cites W2009029675 @default.
- W2026063973 cites W2010083963 @default.
- W2026063973 cites W2010621350 @default.