FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026064511> ?p ?o ?g. }

• W2026064511 endingPage "835" @default.
• W2026064511 startingPage "823" @default.
• W2026064511 abstract "The vitronectin receptor (VnR or α v β 3 ) belongs to the cytoadhesin subclass of the integrin family. This subclass consists of two receptors which have the β 3 subunit in common: GP IIb–IIIa complexes (or α IIb β 3 ) and VnR. We report the subcellular distribution of VnR within human platelets as determined by immunogold staining of ultrathin frozen sections and transmission electron microscopy. Monoclonal antibodies directed against: (i) the α v subunit (LM142, AMF7, CLB‐706), or (ii) an epitope specific to the complex (LM609) were used. Although VnR is present on platelets, it is a minor component. We therefore first compared several different staining procedures to detect this integrin. Optimal localization of VnR was obtained using a multistep procedure in which biotinylated anti‐mouse IgG and a monoclonal anti‐biotin antibody provided staining enhancement. Results showed that although present on the surface, α v β 3 was mostly detected in internal membrane systems including those of α‐granules. Occasionally, platelet sections showed special vesicular structures covered by gold particles. These were often localized at the edge or immediately under the plasma membrane and their origin remains unclear. An internal pool of α v β 3 was confirmed by flow cytometry and by using platelets from a patient with type I Glanzmann's thrombasthenia arising from a GP IIb gene defect. We also investigated the presence of VnR in megakaryocytes (MK) obtained from normal human bone marrow. A fluorescence study showed VnR in small MK with unilobulated nuclei, suggesting that synthesis of this integrin occurs early during megakaryocytopoiesis. In mature cells, VnR expression had decreased relative to GP IIb–IIIa, although intracellular staining was present in EM and α‐granules were again labelled." @default.
• W2026064511 created "2016-06-24" @default.
• W2026064511 creator A5019084323 @default.
• W2026064511 creator A5042115697 @default.
• W2026064511 creator A5047076741 @default.
• W2026064511 date "1997-03-01" @default.
• W2026064511 modified "2023-09-27" @default.
• W2026064511 title "Ultrastructural analysis of the distribution of the vitronectin receptor (α _v β ₃ ) in human platelets and megakaryocytes reveals an intracellular pool and labelling of the α‐granule membrane" @default.
• W2026064511 cites W1520666812 @default.
• W2026064511 cites W152541204 @default.
• W2026064511 cites W1542933458 @default.
• W2026064511 cites W1562376535 @default.
• W2026064511 cites W1572786395 @default.
• W2026064511 cites W1577857859 @default.
• W2026064511 cites W1785730200 @default.
• W2026064511 cites W1964441922 @default.
• W2026064511 cites W1965354507 @default.
• W2026064511 cites W1967629973 @default.
• W2026064511 cites W1986866278 @default.
• W2026064511 cites W2001753204 @default.
• W2026064511 cites W200546789 @default.
• W2026064511 cites W2006878196 @default.
• W2026064511 cites W2011666432 @default.
• W2026064511 cites W2013381560 @default.
• W2026064511 cites W2022087377 @default.
• W2026064511 cites W2026179972 @default.
• W2026064511 cites W2029773366 @default.
• W2026064511 cites W2032740965 @default.
• W2026064511 cites W2044806537 @default.
• W2026064511 cites W2065155390 @default.
• W2026064511 cites W2073133043 @default.
• W2026064511 cites W2075386107 @default.
• W2026064511 cites W2078172180 @default.
• W2026064511 cites W2111636856 @default.
• W2026064511 cites W2113049699 @default.
• W2026064511 cites W2113324173 @default.
• W2026064511 cites W2120042379 @default.
• W2026064511 cites W2161602614 @default.
• W2026064511 cites W2189095591 @default.
• W2026064511 cites W2289682612 @default.
• W2026064511 cites W2342373848 @default.
• W2026064511 cites W2397073784 @default.
• W2026064511 cites W2408485211 @default.
• W2026064511 cites W2463636925 @default.
• W2026064511 cites W2475082298 @default.
• W2026064511 cites W293390614 @default.
• W2026064511 cites W298920371 @default.
• W2026064511 cites W3116925564 @default.
• W2026064511 cites W80400373 @default.
• W2026064511 doi "https://doi.org/10.1046/j.1365-2141.1997.d01-2109.x" @default.
• W2026064511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9074427" @default.
• W2026064511 hasPublicationYear "1997" @default.
• W2026064511 type Work @default.
• W2026064511 sameAs 2026064511 @default.
• W2026064511 citedByCount "37" @default.
• W2026064511 countsByYear W20260645112012 @default.
• W2026064511 countsByYear W20260645112013 @default.
• W2026064511 countsByYear W20260645112016 @default.
• W2026064511 countsByYear W20260645112018 @default.
• W2026064511 countsByYear W20260645112021 @default.
• W2026064511 countsByYear W20260645112022 @default.
• W2026064511 crossrefType "journal-article" @default.
• W2026064511 hasAuthorship W2026064511A5019084323 @default.
• W2026064511 hasAuthorship W2026064511A5042115697 @default.
• W2026064511 hasAuthorship W2026064511A5047076741 @default.
• W2026064511 hasBestOaLocation W20260645111 @default.
• W2026064511 hasConcept C109159458 @default.
• W2026064511 hasConcept C153911025 @default.
• W2026064511 hasConcept C159654299 @default.
• W2026064511 hasConcept C164144092 @default.
• W2026064511 hasConcept C170493617 @default.
• W2026064511 hasConcept C195616568 @default.
• W2026064511 hasConcept C195687474 @default.
• W2026064511 hasConcept C203014093 @default.
• W2026064511 hasConcept C2777918643 @default.
• W2026064511 hasConcept C2779705218 @default.
• W2026064511 hasConcept C28328180 @default.
• W2026064511 hasConcept C30030713 @default.
• W2026064511 hasConcept C542903549 @default.
• W2026064511 hasConcept C55493867 @default.
• W2026064511 hasConcept C86803240 @default.
• W2026064511 hasConcept C89560881 @default.
• W2026064511 hasConcept C95444343 @default.
• W2026064511 hasConceptScore W2026064511C109159458 @default.
• W2026064511 hasConceptScore W2026064511C153911025 @default.
• W2026064511 hasConceptScore W2026064511C159654299 @default.
• W2026064511 hasConceptScore W2026064511C164144092 @default.
• W2026064511 hasConceptScore W2026064511C170493617 @default.
• W2026064511 hasConceptScore W2026064511C195616568 @default.
• W2026064511 hasConceptScore W2026064511C195687474 @default.
• W2026064511 hasConceptScore W2026064511C203014093 @default.
• W2026064511 hasConceptScore W2026064511C2777918643 @default.
• W2026064511 hasConceptScore W2026064511C2779705218 @default.
• W2026064511 hasConceptScore W2026064511C28328180 @default.
• W2026064511 hasConceptScore W2026064511C30030713 @default.
• W2026064511 hasConceptScore W2026064511C542903549 @default.
• W2026064511 hasConceptScore W2026064511C55493867 @default.
• W2026064511 hasConceptScore W2026064511C86803240 @default.

• next