Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026072954> ?p ?o ?g. }
- W2026072954 endingPage "230" @default.
- W2026072954 startingPage "206" @default.
- W2026072954 abstract "Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy." @default.
- W2026072954 created "2016-06-24" @default.
- W2026072954 creator A5002142585 @default.
- W2026072954 creator A5002661071 @default.
- W2026072954 creator A5002900771 @default.
- W2026072954 creator A5009015359 @default.
- W2026072954 creator A5017644527 @default.
- W2026072954 creator A5021384155 @default.
- W2026072954 creator A5040629418 @default.
- W2026072954 creator A5058239203 @default.
- W2026072954 creator A5063097729 @default.
- W2026072954 creator A5075726507 @default.
- W2026072954 creator A5075917840 @default.
- W2026072954 creator A5090604698 @default.
- W2026072954 date "2014-05-01" @default.
- W2026072954 modified "2023-09-28" @default.
- W2026072954 title "Antioxidant gene therapy against neuronal cell death" @default.
- W2026072954 cites W1452893412 @default.
- W2026072954 cites W1481060574 @default.
- W2026072954 cites W1481263059 @default.
- W2026072954 cites W1487243507 @default.
- W2026072954 cites W1499973051 @default.
- W2026072954 cites W1500145074 @default.
- W2026072954 cites W1500418512 @default.
- W2026072954 cites W1504816243 @default.
- W2026072954 cites W1517525911 @default.
- W2026072954 cites W1523726718 @default.
- W2026072954 cites W1530199299 @default.
- W2026072954 cites W1532628897 @default.
- W2026072954 cites W1540141415 @default.
- W2026072954 cites W1542142828 @default.
- W2026072954 cites W1545155513 @default.
- W2026072954 cites W1556723959 @default.
- W2026072954 cites W1558564171 @default.
- W2026072954 cites W1561611826 @default.
- W2026072954 cites W1578695981 @default.
- W2026072954 cites W1630502818 @default.
- W2026072954 cites W1635047156 @default.
- W2026072954 cites W1662308449 @default.
- W2026072954 cites W1781948359 @default.
- W2026072954 cites W1782048590 @default.
- W2026072954 cites W1895792354 @default.
- W2026072954 cites W1931706129 @default.
- W2026072954 cites W1946022517 @default.
- W2026072954 cites W1954514489 @default.
- W2026072954 cites W1955466454 @default.
- W2026072954 cites W1964053234 @default.
- W2026072954 cites W1964671322 @default.
- W2026072954 cites W1964895325 @default.
- W2026072954 cites W1965671005 @default.
- W2026072954 cites W1965703692 @default.
- W2026072954 cites W1966513242 @default.
- W2026072954 cites W1968245867 @default.
- W2026072954 cites W1968882667 @default.
- W2026072954 cites W1969195611 @default.
- W2026072954 cites W1969366577 @default.
- W2026072954 cites W1970094644 @default.
- W2026072954 cites W1970240791 @default.
- W2026072954 cites W1970974990 @default.
- W2026072954 cites W1971539719 @default.
- W2026072954 cites W1971573216 @default.
- W2026072954 cites W1971599063 @default.
- W2026072954 cites W1971701992 @default.
- W2026072954 cites W1971820093 @default.
- W2026072954 cites W1971851525 @default.
- W2026072954 cites W1971927321 @default.
- W2026072954 cites W1972130450 @default.
- W2026072954 cites W1973185752 @default.
- W2026072954 cites W1973502470 @default.
- W2026072954 cites W1974619072 @default.
- W2026072954 cites W1975218333 @default.
- W2026072954 cites W1975788427 @default.
- W2026072954 cites W1975896989 @default.
- W2026072954 cites W1976375430 @default.
- W2026072954 cites W1976383697 @default.
- W2026072954 cites W1976619010 @default.
- W2026072954 cites W1976619282 @default.
- W2026072954 cites W1977069725 @default.
- W2026072954 cites W1977817124 @default.
- W2026072954 cites W1977913875 @default.
- W2026072954 cites W1978138384 @default.
- W2026072954 cites W1979458217 @default.
- W2026072954 cites W1979480555 @default.
- W2026072954 cites W1979833383 @default.
- W2026072954 cites W1979837223 @default.
- W2026072954 cites W1982982813 @default.
- W2026072954 cites W1983025467 @default.
- W2026072954 cites W1983066584 @default.
- W2026072954 cites W1983078193 @default.
- W2026072954 cites W1983760621 @default.
- W2026072954 cites W1983968962 @default.
- W2026072954 cites W1984993201 @default.
- W2026072954 cites W1985824891 @default.
- W2026072954 cites W1986070505 @default.
- W2026072954 cites W1986390530 @default.
- W2026072954 cites W1987933993 @default.
- W2026072954 cites W1989138409 @default.
- W2026072954 cites W1989176081 @default.