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- W2026075900 abstract "To selectively induce a thymus-derived (T) cell response to the hapten azophenylarsonate (Ars) we have injected BALB/c mice with the hapten covalently attached to mycobacteria. Spleen suspensions were then tested for evidence of Ars-specific helper function by their ability to restore the in vitro anti-lactoside (Lac) secondary response of T-depleted Lac precursor cells. Helper activity was demonstrated when a double conjugate containing both Lac and Ars was added. Using column procedures which exclude adherent and Ig-bearing cells, and treatment with anti-T antiserum we excluded antibody as the responsible agent and implicated T cells. A comparison of the activity of hapten and protein-specific helper cells revealed differences which may explain the infrequent demonstration of haptenspecific T function following immunization with hapten-protein conjugates. The demonstration of Ars-specific helper activity is interpreted as support for the contention that receptors on T cells are basically similar to those on antibody precursor cells." @default.
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- W2026075900 date "1974-12-01" @default.
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- W2026075900 title "Helper activityin vitro to a defined determinant" @default.
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