FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026087491> ?p ?o ?g. }

• W2026087491 endingPage "654" @default.
• W2026087491 startingPage "653" @default.
• W2026087491 abstract "To the Editor: A 38-year-old French man with a history of chronic juvenile arthritis was referred to the Necker-Enfants Malades University hospital (Paris, France) with a dysenteric syndrome. The patient had returned the day before from a 1-month stay in Port-au-Prince, Haiti, where he spent most of his time in close contact with young children from an orphanage, most of whom had diarrhea. Clinical examination at admission showed fever (39°C), chills, diffuse abdominal pain, bloody diarrhea, and vomiting. The patient received ceftriaxone, which was stopped on day 4 because initial blood and stool cultures were negative for pathogens and clinical signs had completely resolved.Ten days later, he reported the recurrence of diarrhea without fever. A novel stool culture grew Shigella sonnei. An extended-spectrum β-lactamase (ESBL) was detected by double-disk synergy test; the isolate was also resistant to aminoglycosides (except amikacin), tetracycline, and cotrimoxazole. The strain was susceptible to fluoroquinolones and fosfomycin. It also appeared susceptible to azithromycin (MIC 4 μg/mL), although azithromycin MIC for Shigella spp. should be interpreted with caution (1). The patient was successfully treated with azithromycin at a dose of 500 mg/d for 5 days. Azithromycin was preferred to fluoroquinolones to avoid the risk for tendinopathy because of the patient’s history of chronic juvenile arthritis and because this antimicrobial agent was shown to be effective in the treatment of shigellosis caused by multidrug-resistant strains (2).To identify the molecular basis of this ESBL, a series of PCR primers were used for detection of TEM-, SHV-, or CTX-M–type ESBL (3). Only the TEM PCR showed positive results. Sequencing of 2 independent PCR products showed a new allele (www.lahey.org/studies/temtable.asp). Analysis of the deduced amino acid sequence allowed characterization of TEM-137, derived from TEM-1 with 2 substitutions, Arg-16→Ser and Glu-240→Arg. This ESBL (and resistance to aminoglycosides and tetracyclines) was easily transferred to Escherichia coli J53-2 by conjugation.MICs of β-lactams alone or in association with clavulanic acid, were determined by E-test, according to manufacturer’s instructions (AB Biodisk, Solna, Sweden). High-level resistance to ceftazidime (MIC 32 μg/mL) and intermediate resistance to cefotaxime (MIC 8 μg/mL) were observed; the strain remained susceptible to cefepime and imipenem (MIC 0.5 and 0.25 μg/mL, respectively). Clavulanic acid did not restore susceptibility to ceftazidime (MIC 4 μg/mL) but did restore susceptibility to cefotaxime (MIC 0.5 μg/mL). With clavulanic acid, the MIC of cefepime was 0.06 μg/mL.ESBL in S. sonnei is rare worldwide. In Argentina, a CTX-M-2 was found in an isolate of S. sonnei resistant to cefotaxime but not to ceftazidime (4). In South Korea, TEM-15, TEM-17, TEM-19, TEM-20, TEM-52, and CTX-M-14 were characterized in S. sonnei (5); TEM-52 and CTX-M-14 were also widely distributed, particularly in Salmonella spp. (6,7). In Turkey, an isolate of S. sonnei producing CTX-M-3 was reported (8). In Hong Kong, sequencing of 2 S. sonnei isolates showed the presence of CTX-M-14 and CTX-M-15 (9). Finally, in Bangladesh, 2 isolates of S. sonnei with a class A ESBL were reported; they were not characterized at the molecular level, but the resistance phenotypes suggested a CTX-M type (10).In our case, little information on antimicrobial drug resistance could be obtained from Haiti because no systematic investigation on resistance in Enterobacteriaceae is performed. Nevertheless, the emergence of TEM-137 (GenBank accession no. {type:entrez-nucleotide,attrs:{text:AM286274,term_id:110350793,term_text:AM286274}}AM286274) harbored by this imported S. sonnei isolate clearly demonstrates that ESBL-associated shigellosis has emerged in Haiti and that potentially large and severe shigellosis outbreaks could occur, for which the use of azithromycin could be beneficial, as illustrated in our patient. Because treating shigellosis is becoming problematic, it is essential to focus on prevention measures such as simple rules of personal hygiene that might drastically decrease the risk of transmission." @default.
• W2026087491 created "2016-06-24" @default.
• W2026087491 creator A5016846254 @default.
• W2026087491 creator A5061027575 @default.
• W2026087491 creator A5066356842 @default.
• W2026087491 creator A5067788379 @default.
• W2026087491 creator A5088673157 @default.
• W2026087491 date "2007-04-01" @default.
• W2026087491 modified "2023-10-01" @default.
• W2026087491 title "Novel Extended-spectrum β-Lactamase inShigella sonnei" @default.
• W2026087491 cites W1975706393 @default.
• W2026087491 cites W1985516599 @default.
• W2026087491 cites W2112221449 @default.
• W2026087491 cites W2114897000 @default.
• W2026087491 cites W2125096701 @default.
• W2026087491 cites W2130874417 @default.
• W2026087491 cites W2147999937 @default.
• W2026087491 cites W2151460656 @default.
• W2026087491 cites W2158920301 @default.
• W2026087491 cites W2167075593 @default.
• W2026087491 cites W4232137050 @default.
• W2026087491 doi "https://doi.org/10.3201/eid1304.061160" @default.
• W2026087491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2725971" @default.
• W2026087491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17561568" @default.
• W2026087491 hasPublicationYear "2007" @default.
• W2026087491 type Work @default.
• W2026087491 sameAs 2026087491 @default.
• W2026087491 citedByCount "4" @default.
• W2026087491 crossrefType "journal-article" @default.
• W2026087491 hasAuthorship W2026087491A5016846254 @default.
• W2026087491 hasAuthorship W2026087491A5061027575 @default.
• W2026087491 hasAuthorship W2026087491A5066356842 @default.
• W2026087491 hasAuthorship W2026087491A5067788379 @default.
• W2026087491 hasAuthorship W2026087491A5088673157 @default.
• W2026087491 hasBestOaLocation W20260874911 @default.
• W2026087491 hasConcept C104317684 @default.
• W2026087491 hasConcept C121332964 @default.
• W2026087491 hasConcept C156778621 @default.
• W2026087491 hasConcept C2776986154 @default.
• W2026087491 hasConcept C2911111840 @default.
• W2026087491 hasConcept C54355233 @default.
• W2026087491 hasConcept C547475151 @default.
• W2026087491 hasConcept C62520636 @default.
• W2026087491 hasConcept C86803240 @default.
• W2026087491 hasConcept C89423630 @default.
• W2026087491 hasConceptScore W2026087491C104317684 @default.
• W2026087491 hasConceptScore W2026087491C121332964 @default.
• W2026087491 hasConceptScore W2026087491C156778621 @default.
• W2026087491 hasConceptScore W2026087491C2776986154 @default.
• W2026087491 hasConceptScore W2026087491C2911111840 @default.
• W2026087491 hasConceptScore W2026087491C54355233 @default.
• W2026087491 hasConceptScore W2026087491C547475151 @default.
• W2026087491 hasConceptScore W2026087491C62520636 @default.
• W2026087491 hasConceptScore W2026087491C86803240 @default.
• W2026087491 hasConceptScore W2026087491C89423630 @default.
• W2026087491 hasIssue "4" @default.
• W2026087491 hasLocation W20260874911 @default.
• W2026087491 hasLocation W20260874912 @default.
• W2026087491 hasLocation W20260874913 @default.
• W2026087491 hasLocation W20260874914 @default.
• W2026087491 hasLocation W20260874915 @default.
• W2026087491 hasLocation W20260874916 @default.
• W2026087491 hasOpenAccess W2026087491 @default.
• W2026087491 hasPrimaryLocation W20260874911 @default.
• W2026087491 hasRelatedWork W1787674092 @default.
• W2026087491 hasRelatedWork W2013201849 @default.
• W2026087491 hasRelatedWork W2038580899 @default.
• W2026087491 hasRelatedWork W2056340773 @default.
• W2026087491 hasRelatedWork W2097240139 @default.
• W2026087491 hasRelatedWork W2139586165 @default.
• W2026087491 hasRelatedWork W2415118283 @default.
• W2026087491 hasRelatedWork W3005255350 @default.
• W2026087491 hasRelatedWork W4310052592 @default.
• W2026087491 hasRelatedWork W4318473640 @default.
• W2026087491 hasVolume "13" @default.
• W2026087491 isParatext "false" @default.
• W2026087491 isRetracted "false" @default.
• W2026087491 magId "2026087491" @default.
• W2026087491 workType "article" @default.