FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026091504> ?p ?o ?g. }

• W2026091504 endingPage "314" @default.
• W2026091504 startingPage "309" @default.
• W2026091504 abstract "Exposure to factors released from tobacco during chewing or smoking is recognized as a major risk factor for oral carcinogenesis and influences the phenotype of oral epithelial cells and fibroblasts within the underlying stroma. Micro(mi)RNA can regulate the expression of genes within cells, and previous studies show that tobacco products can alter the miRNA profiles in lung epithelial cells. However, the molecular alterations occurring in oral fibroblasts exposed to tobacco constituents remain to be elucidated.Oral fibroblasts were exposed to cigarette smoke condensate (CSC) and miRNA expression compared to untreated controls using tiling low-density arrays (TLDA). Expression of miRNA-145 was confirmed by quantitative (q)RT-PCR. The effect of CSC on fibroblast cell viability, motility and matrix metalloproteinase (MMP)-2 expression was measured using MTS, a wound scratch assay and qRT-PCR, respectively. Oral cancer cell migration in response to culture supernatants from mock, control or pre-miR-145-transfected CSC-treated fibroblasts was analysed by chemotaxis assay.TLDA analysis identified widespread changes in the miRNA expression profile of fibroblasts exposed to CSC. Pri-, pre- and mature miRNA-145 were significantly down-regulated in response to CSC, and this was accompanied by up-regulated expression of MMP-2 and increased migration of fibroblasts compared to untreated controls. Re-expression of miR-145 abrogated the ability of fibroblasts to promote oral cancer cell chemotaxis in response to CSC.These findings suggest that tobacco constituents influence the expression of miRNA within oral fibroblasts promoting a phenotype that increases oral cancer migration and sheds new light on the mechanisms underlying oral cancer pathogenesis." @default.
• W2026091504 created "2016-06-24" @default.
• W2026091504 creator A5007362772 @default.
• W2026091504 creator A5025894707 @default.
• W2026091504 creator A5026798553 @default.
• W2026091504 creator A5034827002 @default.
• W2026091504 creator A5077429835 @default.
• W2026091504 creator A5089960944 @default.
• W2026091504 date "2012-11-23" @default.
• W2026091504 modified "2023-10-16" @default.
• W2026091504 title "Cigarette smoke condensate promotes pro-tumourigenic stromal-epithelial interactions by suppressing miR-145" @default.
• W2026091504 cites W1964575719 @default.
• W2026091504 cites W1999019336 @default.
• W2026091504 cites W2013721931 @default.
• W2026091504 cites W2025199554 @default.
• W2026091504 cites W2050820138 @default.
• W2026091504 cites W2056171781 @default.
• W2026091504 cites W2062809449 @default.
• W2026091504 cites W2066441178 @default.
• W2026091504 cites W2081911461 @default.
• W2026091504 cites W2092800030 @default.
• W2026091504 cites W2102161750 @default.
• W2026091504 cites W2108836663 @default.
• W2026091504 cites W2110935705 @default.
• W2026091504 cites W2115874527 @default.
• W2026091504 cites W2125237084 @default.
• W2026091504 cites W2128488838 @default.
• W2026091504 cites W2148575470 @default.
• W2026091504 cites W2155954232 @default.
• W2026091504 cites W2162097274 @default.
• W2026091504 doi "https://doi.org/10.1111/jop.12017" @default.
• W2026091504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23173553" @default.
• W2026091504 hasPublicationYear "2012" @default.
• W2026091504 type Work @default.
• W2026091504 sameAs 2026091504 @default.
• W2026091504 citedByCount "22" @default.
• W2026091504 countsByYear W20260915042013 @default.
• W2026091504 countsByYear W20260915042014 @default.
• W2026091504 countsByYear W20260915042015 @default.
• W2026091504 countsByYear W20260915042016 @default.
• W2026091504 countsByYear W20260915042017 @default.
• W2026091504 countsByYear W20260915042018 @default.
• W2026091504 countsByYear W20260915042019 @default.
• W2026091504 countsByYear W20260915042020 @default.
• W2026091504 countsByYear W20260915042021 @default.
• W2026091504 countsByYear W20260915042022 @default.
• W2026091504 crossrefType "journal-article" @default.
• W2026091504 hasAuthorship W2026091504A5007362772 @default.
• W2026091504 hasAuthorship W2026091504A5025894707 @default.
• W2026091504 hasAuthorship W2026091504A5026798553 @default.
• W2026091504 hasAuthorship W2026091504A5034827002 @default.
• W2026091504 hasAuthorship W2026091504A5077429835 @default.
• W2026091504 hasAuthorship W2026091504A5089960944 @default.
• W2026091504 hasConcept C104317684 @default.
• W2026091504 hasConcept C121608353 @default.
• W2026091504 hasConcept C137738243 @default.
• W2026091504 hasConcept C145059251 @default.
• W2026091504 hasConcept C1491633281 @default.
• W2026091504 hasConcept C16930146 @default.
• W2026091504 hasConcept C203014093 @default.
• W2026091504 hasConcept C2780381497 @default.
• W2026091504 hasConcept C502942594 @default.
• W2026091504 hasConcept C53227056 @default.
• W2026091504 hasConcept C54009773 @default.
• W2026091504 hasConcept C54355233 @default.
• W2026091504 hasConcept C555283112 @default.
• W2026091504 hasConcept C81885089 @default.
• W2026091504 hasConcept C86803240 @default.
• W2026091504 hasConceptScore W2026091504C104317684 @default.
• W2026091504 hasConceptScore W2026091504C121608353 @default.
• W2026091504 hasConceptScore W2026091504C137738243 @default.
• W2026091504 hasConceptScore W2026091504C145059251 @default.
• W2026091504 hasConceptScore W2026091504C1491633281 @default.
• W2026091504 hasConceptScore W2026091504C16930146 @default.
• W2026091504 hasConceptScore W2026091504C203014093 @default.
• W2026091504 hasConceptScore W2026091504C2780381497 @default.
• W2026091504 hasConceptScore W2026091504C502942594 @default.
• W2026091504 hasConceptScore W2026091504C53227056 @default.
• W2026091504 hasConceptScore W2026091504C54009773 @default.
• W2026091504 hasConceptScore W2026091504C54355233 @default.
• W2026091504 hasConceptScore W2026091504C555283112 @default.
• W2026091504 hasConceptScore W2026091504C81885089 @default.
• W2026091504 hasConceptScore W2026091504C86803240 @default.
• W2026091504 hasIssue "4" @default.
• W2026091504 hasLocation W20260915041 @default.
• W2026091504 hasLocation W20260915042 @default.
• W2026091504 hasOpenAccess W2026091504 @default.
• W2026091504 hasPrimaryLocation W20260915041 @default.
• W2026091504 hasRelatedWork W2007948417 @default.
• W2026091504 hasRelatedWork W2350997596 @default.
• W2026091504 hasRelatedWork W2766563914 @default.
• W2026091504 hasRelatedWork W2794233632 @default.
• W2026091504 hasRelatedWork W2887821049 @default.
• W2026091504 hasRelatedWork W2984941165 @default.
• W2026091504 hasRelatedWork W3029459600 @default.
• W2026091504 hasRelatedWork W3030073087 @default.
• W2026091504 hasRelatedWork W3194183607 @default.
• W2026091504 hasRelatedWork W580084715 @default.

• next