Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026091879> ?p ?o ?g. }
- W2026091879 endingPage "2441" @default.
- W2026091879 startingPage "2437" @default.
- W2026091879 abstract "An expressed gene for gamma 1 chain of MC 101 myeloma was cloned from a phage library containing partial EcoRI digests of MC 101 DNA. The cloned DNA was analyzed by restriction enzyme cleavage, Southern blot hybridization, R-loop formation, and nucleotide sequence determination. The results indicate that the expressed gamma 1 chain gene comprises at least four germline DNA segments, namely a variable-region gene, a segment of the 5' flanking region of the mu chain gene (containing J regions), a segment of the 5' flanking region of the alpha chain gene, and the gamma 1 chain gene with its flanking regions. The presence of the alpha chain gene-flanking switch (S) region (S alpha region) at the 5' side of the gamma 1 chain gene-flanking region (S gamma 1 region) indicates that the heavy chain class switch may not be mediated by stepwise linear deletion along the order of the heavy chain constant-region genes (5'-mu-gamma 3-gamma 1-gamma 2b-gamma 2a-alpha-3'). We propose a siter-chromatid exchange model that explains class switch-associated deletion of heavy chain genes by unequal crossing-over events between sister chromatids." @default.
- W2026091879 created "2016-06-24" @default.
- W2026091879 creator A5016712767 @default.
- W2026091879 creator A5019039647 @default.
- W2026091879 creator A5034292099 @default.
- W2026091879 creator A5039095558 @default.
- W2026091879 creator A5041402524 @default.
- W2026091879 creator A5044223850 @default.
- W2026091879 creator A5063582557 @default.
- W2026091879 creator A5083195330 @default.
- W2026091879 creator A5088093637 @default.
- W2026091879 date "1981-04-01" @default.
- W2026091879 modified "2023-09-27" @default.
- W2026091879 title "Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism." @default.
- W2026091879 cites W1558619436 @default.
- W2026091879 cites W1570803214 @default.
- W2026091879 cites W1619343167 @default.
- W2026091879 cites W1968121029 @default.
- W2026091879 cites W1974434185 @default.
- W2026091879 cites W1976291588 @default.
- W2026091879 cites W1981042444 @default.
- W2026091879 cites W1982305495 @default.
- W2026091879 cites W1984387553 @default.
- W2026091879 cites W1986038306 @default.
- W2026091879 cites W1986900875 @default.
- W2026091879 cites W1988591763 @default.
- W2026091879 cites W1992595091 @default.
- W2026091879 cites W1995420892 @default.
- W2026091879 cites W1996913802 @default.
- W2026091879 cites W2005463030 @default.
- W2026091879 cites W2007643304 @default.
- W2026091879 cites W2007647936 @default.
- W2026091879 cites W2009792321 @default.
- W2026091879 cites W2009854285 @default.
- W2026091879 cites W2014435813 @default.
- W2026091879 cites W2034408116 @default.
- W2026091879 cites W2037749628 @default.
- W2026091879 cites W2038139201 @default.
- W2026091879 cites W2040276985 @default.
- W2026091879 cites W2045402478 @default.
- W2026091879 cites W2050535354 @default.
- W2026091879 cites W2056221944 @default.
- W2026091879 cites W2056680667 @default.
- W2026091879 cites W2063352158 @default.
- W2026091879 cites W2070855057 @default.
- W2026091879 cites W2074614319 @default.
- W2026091879 cites W2088984288 @default.
- W2026091879 cites W2090627508 @default.
- W2026091879 cites W2091810736 @default.
- W2026091879 cites W2137414170 @default.
- W2026091879 cites W2227641875 @default.
- W2026091879 doi "https://doi.org/10.1073/pnas.78.4.2437" @default.
- W2026091879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/319361" @default.
- W2026091879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6787603" @default.
- W2026091879 hasPublicationYear "1981" @default.
- W2026091879 type Work @default.
- W2026091879 sameAs 2026091879 @default.
- W2026091879 citedByCount "95" @default.
- W2026091879 crossrefType "journal-article" @default.
- W2026091879 hasAuthorship W2026091879A5016712767 @default.
- W2026091879 hasAuthorship W2026091879A5019039647 @default.
- W2026091879 hasAuthorship W2026091879A5034292099 @default.
- W2026091879 hasAuthorship W2026091879A5039095558 @default.
- W2026091879 hasAuthorship W2026091879A5041402524 @default.
- W2026091879 hasAuthorship W2026091879A5044223850 @default.
- W2026091879 hasAuthorship W2026091879A5063582557 @default.
- W2026091879 hasAuthorship W2026091879A5083195330 @default.
- W2026091879 hasAuthorship W2026091879A5088093637 @default.
- W2026091879 hasBestOaLocation W20260918792 @default.
- W2026091879 hasConcept C104317684 @default.
- W2026091879 hasConcept C128319531 @default.
- W2026091879 hasConcept C130123407 @default.
- W2026091879 hasConcept C133307689 @default.
- W2026091879 hasConcept C152204938 @default.
- W2026091879 hasConcept C153911025 @default.
- W2026091879 hasConcept C54355233 @default.
- W2026091879 hasConcept C552990157 @default.
- W2026091879 hasConcept C86803240 @default.
- W2026091879 hasConcept C96007430 @default.
- W2026091879 hasConceptScore W2026091879C104317684 @default.
- W2026091879 hasConceptScore W2026091879C128319531 @default.
- W2026091879 hasConceptScore W2026091879C130123407 @default.
- W2026091879 hasConceptScore W2026091879C133307689 @default.
- W2026091879 hasConceptScore W2026091879C152204938 @default.
- W2026091879 hasConceptScore W2026091879C153911025 @default.
- W2026091879 hasConceptScore W2026091879C54355233 @default.
- W2026091879 hasConceptScore W2026091879C552990157 @default.
- W2026091879 hasConceptScore W2026091879C86803240 @default.
- W2026091879 hasConceptScore W2026091879C96007430 @default.
- W2026091879 hasIssue "4" @default.
- W2026091879 hasLocation W20260918791 @default.
- W2026091879 hasLocation W20260918792 @default.
- W2026091879 hasLocation W20260918793 @default.
- W2026091879 hasLocation W20260918794 @default.
- W2026091879 hasOpenAccess W2026091879 @default.
- W2026091879 hasPrimaryLocation W20260918791 @default.
- W2026091879 hasRelatedWork W1558011539 @default.
- W2026091879 hasRelatedWork W1571788735 @default.